24 research outputs found

    Use of portable blood physiology point-of-care devices for basic and applied research on vertebrates: a review

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    Non-human vertebrate blood is commonly collected and assayed for a variety of applications, including veterinary diagnostics and physiological research. Small, often non-lethal samples enable the assessment and monitoring of the physiological state and health of the individual. Traditionally, studies that rely on blood physiology have focused on captive animals or, in studies conducted in remote settings, have required the preservation and transport of samples for later analysis. In either situation, large, laboratory-bound equipment and traditional assays and analytical protocols are required. The use of point-of-care (POC) devices to measure various secondary blood physiological parameters, such as metabolites, blood gases and ions, has become increasingly popular recently, due to immediate results and their portability, which allows the freedom to study organisms in the wild. Here, we review the current uses of POC devices and their applicability to basic and applied studies on a variety of non-domesticated species. We located 79 individual studies that focused on non-domesticated vertebrates, including validation and application of POC tools. Studies focused on a wide spectrum of taxa, including mammals, birds and herptiles, although the majority of studies focused on fish, and typical variables measured included blood glucose, lactate and pH. We found that calibrations for species-specific blood physiology values are necessary, because ranges can vary within and among taxa and are sometimes outside the measurable range of the devices. In addition, although POC devices are portable and robust, most require durable cases, they are seldom waterproof/water-resistant, and factors such as humidity and temperature can affect the performance of the device. Overall, most studies concluded that POC devices are suitable alternatives to traditional laboratory devices and eliminate the need for transport of samples; however, there is a need for greater emphasis on rigorous calibration and validation of these units and appreciation of their limitations

    The Soft Power of Anglia: British Cold War Cultural Diplomacy in the USSR

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    This article contributes to the growing literature on the cultural Cold War through an exploration of the British national projection magazine Anglia, produced by the Foreign Office for distribution in the USSR from 1962 to 1992. As well as drawing attention to the significance of national magazines in general, the article sheds light on Britain's distinctive approach to propaganda and cultural diplomacy during the Cold War. It considers why the magazine was set up and endured for so long, despite considerable reservations about its value. It examines how Britain was projected in a manner that accorded with British understandings about the need for ‘subtle’ propaganda. Finally, it addresses the question of the magazine's impact in the USSR

    A randomized, open-label, multicentre, phase 2/3 study to evaluate the safety and efficacy of lumiliximab in combination with fludarabine, cyclophosphamide and rituximab versus fludarabine, cyclophosphamide and rituximab alone in subjects with relapsed chronic lymphocytic leukaemia

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    ‘Bombed into stardom!’: Roddy McDowall, ‘British evacuee star’ in Hollywood

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    This article considers the beginnings of the British actor Roddy McDowall's career as a child star in Hollywood. Following his relocation to the United States in October 1940 and signing a contract with Twentieth Century-Fox, McDowall quickly became one of Hollywood's most popular juvenile actors. For the duration of the Second World War, McDowall's star image was indissoluble from his status as a war guest: he was ‘a British evacuee star’. McDowall thus became an unofficial ambassador for the British nation, much like his fellow evacuees, who were widely recognised for their work improving Anglo-American relations. In the management of McDowall's image, and in his screen performances, there is a discernible effort to substantiate certain attitudes about the character and attributes of the British nation but also to challenge certain prejudices about English sissy boys. McDowall's star text was carefully managed so that the image of the actor presented by the media and the fictional characters he played on screen congealed in a productive way to inspire among American audiences specific sentiments about the British and America's relationship with the British nation during wartime. Analysing the representation of McDowall in American film magazines during the early 1940s, as well as his performances in three war-themed productions – Confirm or Deny (1941), On the Sunny Side (1942) and The White Cliffs of Dover (1944) – I explore the ways McDowall's star text functioned in its geopolitical and bio-political contexts
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