Robustness of double-layer group-dependent combat network with cascading failure

The networked combat system-of-system (CSOS) is the trend of combat development with the innovation of technology. The achievement of combat effectiveness requires CSOS to have a good ability to deal with external interference. Here we report a modeling method of CSOS from the perspective of complex networks and explore the robustness of the combat network based on this. Firstly, a more realistic double-layer heterogeneous dependent combat network model is established. Then, the conditional group dependency situation is considered to design failure rules for dependent failure, and the coupling relation between the double-layer subnets is analyzed for cascading failure. Based on this, the initial load and capacity of the node are defined, respectively, as well as the load redistribution strategy and the status judgment rules for the cascading failure model. Simulation experiments are carried out by changing the attack modes and different parameters, and the results show that the robustness of the combat network can be effectively improved by improving the tolerance limit of one-way dependency of the functional net, the node capacity of the functional subnet and the tolerance of the overload state. The conclusions of this paper can provide a useful reference for network structure optimization and network security protection in the military field

Multi-frequency VLBI Observations of the M 84 Inner Jet/Counterjet

Observational studies of inner-most regions of the edge-on jets in nearby active galactic nuclei (AGN) are crucial to understand their kinematics and morphology. For the inner jet of the nearby low luminosity AGN in M 84, we present new high-sensitivity observations with very long baseline interferometry since 2019, as well as archival Very Long Baseline Array observations in 2014. We find that the compact core in M 84 has an inverted-to-flat spectrum from 1.5 to 88 GHz. Based on the turnover frequency of $4.2\pm 0.2$ GHz in the spectrum, we estimated a magnetic field strength of 1-10mG and an electron number density of $\sim 10^5 cm^{-3}$ in the core region. Three inner jet components within $\sim 3$ mas from the core are identified and traced in the images at 22 GHz, whose apparent speeds are 0.11 c, 0.27 c, and 0.32 c, respectively. We calculate the viewing angle of $\sim58$ degree for the inner jet based on the proper motion and the flux ratio of jet-to-counterjet. A propagating sinusoidal model with a wavelength of $\sim 3.4$ mas is used to fit the helical morphology of the jet extended to 20 mas ($\sim 2.2\times 10^4$ Schwarzschild Radii).Comment: 9 pages, 5 figures, accepted by the Ap

Isolation and Characterization of Clinical Listeria monocytogenes in Beijing, China, 2014–2016

Listeria monocytogenes is an important foodborne pathogen with a significant impact on public health worldwide. A great number of outbreaks caused by L. monocytogenes has been reported, especially in the United States, and European countries. However, listeriosis has not yet been included in notifiable disease in China, and thus information on this infection has been scarce among the Chinese population. In this study, we described a 3-year surveillance of listeriosis in Beijing, China. Fifty-six L. monocytogenes strains isolated from 49 clinical infectious cases (27 pregnancy-associated infections and 22 non-pregnancy-associated infections) were analyzed by serotyping, pulsed field gel electrophoresis (PFGE), multilocus sequence typing (MLST), and antimicrobial susceptibility testing between 2014 and 2016 in Beijing. The predominant serogroups were 1/2a,3a and 1/2b,3b,7 which accounted for 92% of the overall isolates. Four strains were serogroup 4b,4d,4e, isolated from patients with pregnancy-associated infections. Based on PFGE, these isolates were divided into 32 pulsotypes (PTs) and 3 clusters associated with serogroups. Ten PTs were represented by more than one isolate with PT09 containing the most number of isolates. MLST differentiated the isolates into 18 STs, without new ST designated. The three most common STs were ST8 (18.4%), ST5 (16.3%), and ST87 (12.2%), accounting for 46.9% of the isolates. STs prevalent in other parts of the world were also present in China such as ST1, ST2, ST5, ST8, and ST9 which caused maternal fetal infections or outbreaks. However, the STs and serogroup distribution of clinical L. monocytogenes in Beijing, China was different from those in other countries. Strains of ST1 and ST2 were isolated from patients with pregnancy-associated infection, whereas none of ST155 isolates caused pregnancy-associated cases. Surveillance of molecular characterization will provide important information for prevention of listeriosis. This study also enhances our understanding of genetic diversity of clinical L. monocytogenes in China

Identifying differentially expressed genes in goat mammary epithelial cells induced by overexpression of SOCS3 gene using RNA sequencing

The suppressor of cytokine signaling 3 (SOCS3) is a key signaling molecule that regulates milk synthesis in dairy livestock. However, the molecular mechanism by which SOCS3 regulates lipid synthesis in goat milk remains unclear. This study aimed to screen for key downstream genes associated with lipid synthesis regulated by SOCS3 in goat mammary epithelial cells (GMECs) using RNA sequencing (RNA-seq). Goat SOCS3 overexpression vector (PC-SOCS3) and negative control (PCDNA3.1) were transfected into GMECs. Total RNA from cells after SOCS3 overexpression was used for RNA-seq, followed by differentially expressed gene (DEG) analysis, functional enrichment analysis, and network prediction. SOCS3 overexpression significantly inhibited the synthesis of triacylglycerol, total cholesterol, non-esterified fatty acids, and accumulated lipid droplets. In total, 430 DEGs were identified, including 226 downregulated and 204 upregulated genes, following SOCS3 overexpression. Functional annotation revealed that the DEGs were mainly associated with lipid metabolism, cell proliferation, and apoptosis. We found that the lipid synthesis-related genes, STAT2 and FOXO6, were downregulated. In addition, the proliferation-related genes BCL2, MMP11, and MMP13 were upregulated, and the apoptosis-related gene CD40 was downregulated. In conclusion, six DEGs were identified as key regulators of milk lipid synthesis following SOCS3 overexpression in GMECs. Our results provide new candidate genes and insights into the molecular mechanisms involved in milk lipid synthesis regulated by SOCS3 in goats

Source-Frequency Phase-Referencing Observation of AGNs with KaVA Using Simultaneous Dual-Frequency Receiving

The KVN(Korean VLBI Network)-style simultaneous multi-frequency receiving mode is demonstrated to be promising for mm-VLBI observations. Recently, other Very long baseline interferometry (VLBI) facilities all over the globe start to implement compatible optics systems. Simultaneous dual/multi-frequency VLBI observations at mm wavelengths with international baselines are thus possible. In this paper, we present the results from the first successful simultaneous 22/43 GHz dual-frequency observation with KaVA(KVN and VERA array), including images and astrometric results. Our analysis shows that the newly implemented simultaneous receiving system has brought a significant extension of the coherence time of the 43 GHz visibility phases along the international baselines. The astrometric results obtained with KaVA are consistent with those obtained with the independent analysis of the KVN data. Our results thus confirm the good performance of the simultaneous receiving systems for the non-KVN stations. Future simultaneous observations with more global stations bring even higher sensitivity and micro-arcsecond level astrometric measurements of the targets.Comment: 8 pages, 6 figures, Published in JKA

Super-Resolved Image of M87 Observed with East Asian VLBI Network

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Obtaining high-resolution images at centimeter-or-longer wavelengths is vital for understanding the physics of jets. We reconstructed images from the M87 22 GHz data observed with the East Asian VLBI Network (EAVN) by using the regularized maximum likelihood (RML) method, which is different from the conventional imaging method CLEAN. Consequently, a bright core and jet extending about 30 mas to the northwest were detected with a higher resolution than in the CLEAN image. The width of the jet was 0.5 mas at 0.3 mas from the core, consistent with the width measured in the 86 GHz image in the previous study. In addition, three ridges were able to be detected at around 8 mas from the core, even though the peak-to-peak separation was only 1.0 mas. This indicates that the RML image’s spatial resolution is at least 30% higher than that of the CLEAN image. This study is an important step for future multi-frequency and high-cadence observations of the EAVN to discuss the more detailed structure of the jet and its time variability. © 2023 by the authors. Licensee MDPI, Basel, Switzerland.This research is funded by the following: JSPS (Japan Society for the Promotion of Science) Grant in Aid for Scientific Research (KAKENHI) (A) 22H00157 and (B) 18KK0090 (K.H.). K.H. is also funded by the Mitsubishi Foundation (201911019). Y.C. is funded by the China Postdoctoral Science Foundation (2022M712084). K.A. is financially supported by grants from the National Science Foundation (AST-1935980, AST-2034306, AST-2107681, AST-2132700, OMA-2029670). Y.M. is supported by the National Natural Science Foundation of China (12273022) and the Shanghai pilot program of international scientists for basic research (22JC1410600). R.-S.L. is supported by the Max Planck Partner Group of the MPG and the CAS, the Key Program of the NSFC (No. 11933007), the Key Research Program of Frontier Sciences, CAS (No. ZDBS-LY-SLH011), and the Shanghai Pilot Program for Basic Research—CAS, Shanghai Branch (No. JCYJ-SHFY-2022-013). L.C. is supported by the CAS “Light of West China” Program (No. 2021-XBQNXZ-005) and the NSFC (No. U2031212 and 61931002).With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2021-001131-S).Peer reviewe