Fluctuation and Inertia

In this work, using Jacobson's idea: '$\delta$Q=TdS hold for all the local Rindler causal horizons through each spacetime point', we found that the transitions between the excited and ground state of a particle in a linear acceleration satisfy the fluctuation theorem. The up transition from the ground state to the excited state is an entropy-decreasing process, which requires an external force to contribute equal entropy increase to satisfy the second law of thermodynamics.Comment: 5 page

Sensing as a Service in 6G Perceptive Networks: A Unified Framework for ISAC Resource Allocation

In the upcoming next-generation (5G-Advanced and 6G) wireless networks, sensing as a service will play a more important role than ever before. Recently, the concept of perceptive network is proposed as a paradigm shift that provides sensing and communication (S&C) services simultaneously. This type of technology is typically referred to as Integrated Sensing and Communications (ISAC). In this paper, we propose the concept of sensing quality of service (QoS) in terms of diverse applications. Specifically, the probability of detection, the Cramer-Rao bound (CRB) for parameter estimation and the posterior CRB for moving target indication are employed to measure the sensing QoS for detection, localization, and tracking, respectively. Then, we establish a unified framework for ISAC resource allocation, where the fairness and the comprehensiveness optimization criteria are considered for the aforementioned sensing services. The proposed schemes can flexibly allocate the limited power and bandwidth resources according to both S&C QoSs. Finally, we study the performance trade-off between S&C services in different resource allocation schemes by numerical simulations

Fucoxanthin attenuates LPS-induced acute lung injury via inhibition of the TLR4/MYD88 signaling axis

Acute lung injury (ALI) is a critical clinical condition with a high mortality rate. It is believed that the inflammatory storm is a critical contributor to the occurrence of ALI. Fucoxanthin is a natural extract from marine seaweed with remarkable biological properties, including antioxidant, anti-tumor, and anti-obesity. However, the anti-inflammatory activity of Fucoxanthin has not been extensively studied. The current study aimed to elucidate the effects and the molecular mechanism of Fucoxanthin on lipopolysaccharide-induced acute lung injury. In this study, Fucoxanthin efficiently reduced the mRNA expression of pro-inflammatory factors, including IL-10, IL-6, iNOS, and Cox-2, and down-regulated the NF-kappaB signaling pathway in Raw264.7 macrophages. Furthermore, based on the network pharmacological analysis, our results showed that anti-inflammation signaling pathways were screened as fundamental action mechanisms of Fucoxanthin on ALI. Fucoxanthin also significantly ameliorated the inflammatory responses in LPS-induced ALI mice. Interestingly, our results revealed that Fucoxanthin prevented the expression of TLR4/MyD88 in Raw264.7 macrophages. We further validated Fucoxanthin binds to the TLR4 pocket using molecular docking simulations. Altogether, these results suggest that Fucoxanthin suppresses the TLR4/MyD88 signaling axis by targeting TLR4, which inhibits LPS-induced ALI, and fucoxanthin inhibition may provide a novel strategy for controlling the initiation and progression of ALI

Demonstration of chronometric leveling using transportable optical clocks beyond laser coherence limit

Optical clock network requires the establishment of optical frequency transmission link between multiple optical clocks, utilizing narrow linewidth lasers. Despite achieving link noise levels of 10${^{-20}}$, the final accuracy is limited by the phase noise of the clock laser. Correlation spectroscopy is developed to transmit frequency information between two optical clocks directly, enabling optical clock comparison beyond the phase noise limit of clock lasers, and significantly enhancing the measurement accuracy or shorten the measurement time. In this letter, two compact transportable ${^{40}}$Ca${^+}$ clocks are employed to accomplish the correlation spectroscopy comparison, demonstrating an 10 cm level measurement accuracy of chronometric leveling using a mediocre clock laser with linewidth of 200 Hz. The relative frequency instability reaches $6.0\times10{^{-15}}/\sqrt{\tau/s}$, which is about 20 times better than the result with Rabi spectroscopy using the same clock laser. This research greatly reduces the harsh requirements on the performance of the clock laser, so that an ordinary stable-laser can also be employed in the construction of optical clock network, which is essential for the field applications, especially for the chronometric leveling

Enhancement of Quantum Sensing in a Cavity Optomechanical System around Quantum Critical Point

The precision of quantum sensing could be improved by exploiting quantum phase transitions, where the physical quantity tends to diverge when the system is approaching the quantum critical point. This critical enhancement phenomenon has been applied to the quantum Rabi model in a dynamic framework, showing a promising sensing enhancement without the complex initial state preparation. In this work, we find a quantum phase transition in the coupling cavity-mechanical oscillator system when the coupling strength crosses a critical point, determined by the effective detuning of cavity and frequency of mechanical mode. By utilizing this critical phenomenon, we obtain a prominent enhancement of quantum sensing, such as the position and momentum of the mechanical oscillator. This result provides an alternative method to enhance the quantum sensing of some physical quantities, such as mass, charge, and weak force, in a large mass system

Clinical efficacy of the combined use of levofloxacin and different courses of isoniazid and rifampicin in the treatment of mild spinal tuberculosis

Purpose: To investigate the clinical effectiveness of the combined use of levofloxacin and different courses of isoniazid and rifampicin in the treatment of mild spinal tuberculosis (TB). Methods: The clinic data of 100 patients with light spinal TB were retrospectively reviewed. A double-blind technique was used to divide the patients into 6-month treatment group (M6 group, n = 32), 12-month treatment group (M12 group, n = 34) and 18-month treatment group (M18 group, n = 34). All patients were given isoniazid and rifampicin, in combination with levofloxacin. The effects of the different treatment courses on mild spinal TB were determined. Results: There were significantly higher post-treatment levels of inflammatory factors in M6 group than in M12 and M18 groups (p < 0.001). Moreover, there were significantly higher Visual Analogue Scale (VAS) score and erythrocyte sedimentation rate (ESR), and larger focus size in M6 group than in M12 and M18 groups (p < 0.05). However, after treatment, M18 group had significantly higher total incidence of adverse reactions than M6 and M12 groups (p < 0.05). Conclusion: Compared with the short-course treatment, long-course treatment with isoniazid and rifampicin in combination with levofloxacin is more effective in reducing the levels of inflammatory factors and decreasing focus size in patients with mild spinal TB. However, patients given the 18-month treatment tend to develop more adverse reactions. Therefore, 12-month treatment with the combined therapy is a better therapeutic option