A Simulation Way to Investigate the Reason for Congestion in Urban——A Case Study in Hohhot China

In the case of high density traffic flow, traditional traffic data statistical analysis methods, which not only have certain errors and lead to inaccurate data, but also have many limitations such as labor consumption, can no longer meet the demand for traffic analysis. Drones for traffic data, based on an aerial bird\u27s-eye view, no offset, and error-free complete statistics of urban road shooting section of all data, while greatly reducing cost consumption. A multi-dimensional simulation model is established for the UAV data to the Hohhot central urban area\u27s road simulation platform. This project will test and explore multidimensional data in the simulation platform to investigate the congestion problem in Hohhot\u27s central city, as well as motor vehicle driving characteristics, non-motor vehicle driving behavior, road setting design, and other aspects, and provide optimization solutions for data-driven intelligent traffic control and management.https://digitalcommons.odu.edu/gradposters2023_engineering/1005/thumbnail.jp

β-Catenin–induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor

The transcription factor Microphthalmia-associated transcription factor (MITF) is a lineage-determination factor, which modulates melanocyte differentiation and pigmentation. MITF was recently shown to reside downstream of the canonical Wnt pathway during melanocyte differentiation from pluripotent neural crest cells in zebrafish as well as in mammalian melanocyte lineage cells. Although expression of many melanocytic/pigmentation markers is lost in human melanoma, MITF expression remains intact, even in unpigmented tumors, suggesting a role for MITF beyond its role in differentiation. A significant fraction of primary human melanomas exhibit deregulation (via aberrant nuclear accumulation) of β-catenin, leading us to examine its role in melanoma growth and survival. Here, we show that β-catenin is a potent mediator of growth for melanoma cells in a manner dependent on its downstream target MITF. Moreover, suppression of melanoma clonogenic growth by disruption of β-catenin–T-cell transcription factor/LEF is rescued by constitutive MITF. This rescue occurs largely through a prosurvival mechanism. Thus, β-catenin regulation of MITF expression represents a tissue-restricted pathway that significantly influences the growth and survival behavior of this notoriously treatment-resistant neoplasm

Cytosolic phospholipase A2α–deficient mice are resistant to experimental autoimmune encephalomyelitis

Experimental autoimmune encephalomyelitis (EAE), a Th1-mediated inflammatory disease of the central nervous system (CNS), is a model of human multiple sclerosis. Cytosolic phospholipase A2α (cPLA2α), which initiates production of prostaglandins, leukotrienes, and platelet-activating factor, is present in EAE lesions. Using myelin oligodendrocyte glycoprotein (MOG) immunization, as well as an adoptive transfer model, we showed that cPLA2α−/− mice are resistant to EAE. Histologic examination of the CNS from MOG-immunized mice revealed extensive inflammatory lesions in the cPLA2α+/− mice, whereas the lesions in cPLA2α−/− mice were reduced greatly or completely absent. MOG-specific T cells generated from WT mice induced less severe EAE in cPLA2α−/− mice compared with cPLA2α+/− mice, which indicates that cPLA2α plays a role in the effector phase of EAE. Additionally, MOG-specific T cells from cPLA2α−/− mice, transferred into WT mice, induced EAE with delayed onset and lower severity compared with EAE that was induced by control cells; this indicates that cPLA2α also plays a role in the induction phase of EAE. MOG-specific T cells from cPLA2α−/− mice were deficient in production of Th1-type cytokines. Consistent with this deficiency, in vivo administration of IL-12 rendered cPLA2α−/− mice susceptible to EAE. Our data indicate that cPLA2α plays an important role in EAE development and facilitates differentiation of T cells toward the Th1 phenotype

A new entanglement measure based on one-side ONCB projection measurement

Entanglement measure is an important index for computing quantum entanglement. At present, a considerable number of entanglement measures have been proposed. In this study, an entanglement measure for bipartite quantum states in accordance with one-side ONCB (orthogonal normalization complete basis) projection measurement is presented. This study suggests that the measure is well-defined. This measure is expressed as $$E(\rho )$$. It is proven that $$E(\rho )$$ satisfies some necessary properties of quantum entanglement measure (e.g., non-negativity, invariance under local unitary operation, as well as monotonicity under local operation and classical communication (LOCC)). Furthermore, we give a upper bound and a lower bound of $$E(\rho )$$ for bipartite quantum states

A Hydrostatic Pressure-Driven Desalination System for Large-Scale Deep Sea Space Station

Compared with the common marine renewable energy sources like solar, wind, and wave energy, etc., the hydraulic pressure stored in the deep seawater can output stable and successive energy flow. Thus, it can be directly coupled with the reverse osmosis (RO) process to supply drinkable mineral water for crews of Deep Sea Space Station (DSSS). We proposed a novel submarine RO desalination system driven by the hydraulic pressure of deep seawater (SHP-RO), composed of a desalination branch to generate fresh water and a back pressure branch to ensure the depth independence of the desalination. The influences of the deep sea environment on the RO were analyzed, based on which the pretreatment of the seawater and the preparation of the drinkable mineral water were studied. The turbine-based energy recovery scheme was investigated in virtue of the CFD simulation on the flow behavior in the different turbine series. It was predicted that, when the DSSS was located at the depth of 1100 m and the operating pressure of the RO process was 6.0 MPa, for a drinkable water production rate of 240 m3/d, the recovered hydraulic pressure energy can achieve 39.22 kW·h, which was enough for driving electricity consumers in the SHP-RO system

Active and Programmable Metasurfaces with Semiconductor Materials and Devices

Active metasurfaces provide promising tunabilities to artificial meta−atoms with unnatural optical properties and have found important applications in dynamic cloaking, reconfigurable intelligent surfaces, etc. As the development of semiconductor technologies, electrically controlled metasurfaces with semiconductor materials and devices have become the most promising candidate for the dynamic and programmable applications due to the large modulation range, compact footprint, pixel−control capability, and small switching time. Here, a technical review of active and programmable metasurfaces is given in terms of semiconductors, which consists of metasurfaces with diodes, transistors, and newly rising semiconductor materials. Physical models, equivalent circuits, recent advances, and development trends are discussed collectively and critically. This review represents a broad introduction for readers just entering this interesting field and provides perspective and depth for those well−established