Variational Estimation for Multidimensional Generalized Partial Credit Model

Multidimensional item response theory (MIRT) models have generated increasing interest in the psychometrics literature. Efficient approaches for estimating MIRT models with dichotomous responses have been developed, but constructing an equally efficient and robust algorithm for polytomous models has received limited attention. To address this gap, this paper presents a novel Gaussian variational estimation algorithm for the multidimensional generalized partial credit model (MGPCM). The proposed algorithm demonstrates both fast and accurate performance, as illustrated through a series of simulation studies and two real data analyses

A Customized Text Sanitization Mechanism with Differential Privacy

As privacy issues are receiving increasing attention within the Natural Language Processing (NLP) community, numerous methods have been proposed to sanitize texts subject to differential privacy. However, the state-of-the-art text sanitization mechanisms based on metric local differential privacy (MLDP) do not apply to non-metric semantic similarity measures and cannot achieve good trade-offs between privacy and utility. To address the above limitations, we propose a novel Customized Text (CusText) sanitization mechanism based on the original $\epsilon$-differential privacy (DP) definition, which is compatible with any similarity measure. Furthermore, CusText assigns each input token a customized output set of tokens to provide more advanced privacy protection at the token level. Extensive experiments on several benchmark datasets show that CusText achieves a better trade-off between privacy and utility than existing mechanisms. The code is available at https://github.com/sai4july/CusText.Comment: This work has been accepted to the Findings of ACL 202

Evaluation of the cytotoxic effects of sodium hypochlorite on human dental stem cells

Purpose: To investigate the influence of sodium hypochlorite (NaOCl) on human dental stem cell proliferation and differentiation.Method: Dental pulp stem cells (DPSCs), periodontal ligament stem cell (PDLSCs), and gingival mesenchymal stem cells (GMSCs) were treated with NaOCl. Cell viability was evaluated with cellular counting kit-8 (CCK8), and cellular adenosine triphosphate (ATP) levels were analyzed by bromodeoxyuridine (BrdU) incorporation and subsequent flow cytometry. Quantitative polymerase chain reaction (qPCR) and western blotting were performed to detect the expressions of differentiation markers.Results: The viability and ATP levels of all three stem cells types were impaired by NaOCl in a concentration- and time-dependent manners. However, the decrease ATP in GMSCs was less than the other two stem cell population (p < 0.05). NaOCl treatment significantly suppressed the proliferation of dental stem cells (p < 0.05). With regard to differentiation marker expression levels, the decrease in Stro-1 was greater in treatment groups when compared to control on Day 7, while increase in levels of dentin sialophosphoprotein (DSPP), bone sialoprotein (BSP), and osteocalcin (OC) was smaller (p < 0.05). The expressional changes of Stro-1, DSPP, BSP, and OC were more prominent in DPSMs and PDLSCs than in GMSCs.Conclusion: NaOCl dose-dependently impairs the viability, proliferation and differentiation of dental stem cells. Thus, its toxicity to dental stem cells needs to be considered in clinical application.Keywords: Dental stem cells, Sodium hypochlorite, Viability, Proliferation, Differentiatio

Is Fermi 1544-0649 a misaligned blazar? discovering the jet structure with VLBI

Fermi J1544-0649 is a transient GeV source first detected during its GeV flares in 2017. Multi-wavelength observations during the flaring time demonstrate variability and spectral energy distribution(SED) that are typical of a blazar. Other than the flare time, Fermi J1544-0649 is quiet in the GeV band and looks rather like a quiet galaxy (2MASX J15441967-0649156) for a decade. Together with the broad absorption lines feature we further explore the "misaligned blazar scenario". We analyzed the Very Long Baseline Array (VLBA) and East Asian VLBI Network (EAVN) data from 2018 to 2020 and discovered the four jet components from Fermi J1544-0649. We found a viewing angle around 3.7{\deg} to 7.4{\deg}. The lower limit of the viewing angle indicates a blazar with an extremely low duty cycle of the gamma-ray emission, the upper limit of it supports the "misaligned blazar scenario". Follow-up multi-wavelength observations after 2018 show Fermi J1544-0649 remains quiet in GeV, X-ray, and optical bands. Multi-messenger search of neutrinos is also performed, and an excess of 3.1 {\sigma} significance is found for this source.Comment: Accepted for publication in ApJ. 13 pages, 7 figure

Adverse drug events associated with linezolid administration: a real-world pharmacovigilance study from 2004 to 2023 using the FAERS database

Introduction: Linezolid is an oxazolidinone antibiotic that is active against drug-resistant Gram-positive bacteria and multidrug-resistant Mycobacterium tuberculosis. Real-world studies on the safety of linezolid in large populations are lacking. This study aimed to determine the adverse events associated with linezolid in real-world settings by analyzing data from the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS).Methods: We retrospectively extracted reports on adverse drug events (ADEs) from the FAERS database from the first quarter of 2004 to that of 2023. By using disproportionality analysis including reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), along with the multi-item gamma Poisson shrinker (MGPS), we evaluated whether there was a significant association between linezolid and ADE. The time to onset of ADE was further analyzed in the general population and within each age, weight, reporting population, and weight subgroups.Results: A total of 11,176 reports of linezolid as the “primary suspected” drug and 263 significant adverse events of linezolid were identified, including some common adverse events such as thrombocytopenia (n = 1,139, ROR 21.98), anaemia (n = 704, ROR 7.39), and unexpected signals that were not listed on the drug label such as rhabdomyolysis (n = 90, ROR 4.33), and electrocardiogram QT prolonged (n = 73, ROR 4.07). Linezolid-induced adverse reactions involved 27 System Organ Class (SOC). Gender differences existed in ADE signals related to linezolid. The median onset time of all ADEs was 6 days, and most ADEs (n = 3,778) occurred within the first month of linezolid use but some may continue to occur even after a year of treatment (n = 46).Conclusion: This study reports the time to onset of adverse effects in detail at the levels of SOC and specific preferred term (PT). The results of our study provide valuable insights for optimizing the use of linezolid and reducing potential side effects, expected to facilitate the safe use of linezolid in clinical settings

A Novel Reassortant Avian H7N6 Influenza Virus Is Transmissible in Guinea Pigs via Respiratory Droplets

Since 2013, H7N9 and H5N6 avian influenza viruses (AIVs) have caused sporadic human infections and deaths and continued to circulate in the poultry industry. Since 2014, H7N6 viruses which might be reassortants of H7N9 and H5N6 viruses, have been isolated in China. However, the biological properties of H7N6 viruses are unknown. Here, we characterize the receptor binding preference, pathogenicity and transmissibility of a H7N6 virus A/chicken/Hubei/00095/2017(H7N6) (abbreviated HB95), and a closely related H7N9 virus, A/chicken/Hubei/00093/2017(H7N9) (abbreviated HB93), which were isolated from poultry in Hubei Province, China, in 2017. Phylogenetic analyses demonstrated that the hemagglutinin (HA) gene of HB95 is closely related to those of HB93 and human-origin H7N9 viruses, and that the neuraminidase (NA) gene of HB95 shared the highest nucleotide similarity with those of H5N6 viruses. HB95 and HB93 had binding affinity for human-like α2, 6-linked sialic acid receptors and were virulent in mice without prior adaptation. In addition, in guinea pig model, HB93 was transmissible by direct contact, but HB95 was transmissible via respiratory droplets. These results revealed the potential threat to public health posed by H7N6 influenza viruses and emphasized the need for continued surveillance of the circulation of this subtype in poultry

Physical Length and Weight Reduction of Humanoid In-Robot Network with Zonal Architecture

Recently, with the continuous increase in the number of sensors, motors, actuators, radars, data processors and other components carried by humanoid robots, the integration of electronic components within a humanoid is also facing new challenges. Therefore, we focus on the development of sensor networks suitable for humanoid robots to designing an in-robot network (IRN) that can support a large sensor network for reliable data exchange. It was shown that the domain based in-vehicle network (IVN) architectures (DIA) used in the traditional and electric vehicles is gradually moving towards zonal IVN architectures (ZIA). Compared with DIA, ZIA for vehicles is known to provide better network scalability, maintenance convenience, shorter harness length, lighter harness weight, lower data transmission delay, and other several advantages. This paper introduces the structural differences between ZIRA and the domain based IRN architecture (DIRA) for humanoids. Additionally, it compares the differences in the length and weight of wiring harnesses of the two architectures. The results show that as the number of electrical components including sensors increases, ZIRA reduces at least 16% compared to DIRA, the wiring harness length, weight, and its cost

Strength Development and Environmental Assessment of Full Tailings Filling Materials with Various Water-to-Binder Ratios

In order to build green mines, goaf is often filled, supported, and sealed with a high-water material to eliminate a series of environmental problems and safety hazards caused by goaf. In this study, ordinary Portland cement, sulphoaluminate cement, and alkali-activated cement were used as binders to prepare full-tailings high-water materials for filling, with various water-to-cement ratios. The compressive strength development of consolidated tungsten tailings specimens prepared with various curing binders was observed, and the influence of various water–cement ratios on the strength development was analyzed. The environmental impact of mine backfill materials was assessed according to the life cycle theory (LCA), and these mine backfill materials were prepared by using various binders. The results show that when the water-to-binder ratio is 3, the strength of alkali-activated cement can reach 3 MPa at 28 days; at that ratio, the microstructure of alkali-activated cement is more compact. Through LCA analysis, the environmental load of alkali-activated cement is shown to be significantly lower than that of either Portland cement or sulphoaluminate cement; the LCA results show that the primary energy consumption using alkali-activated cement is reduced from the Portland and sulphoaluminate cements by 1319.32 MJ and 945 kg, respectively. These unusual reduction percentages are achieved because the production of alkali-activated cement by LCA does not have any negative environmental impact—the production of alkali-activated cement, with its primary component being industrial byproduct slag, so that the use of alkali-activated cement in tailings’ consolidation has a positive environmental impact