miRNA-guided reprogramming of glucose and glutamine metabolism and its impact on cell adhesion/migration during solid tumor progression

MicroRNAs (miRNAs) are small, non-coding RNAs about 22 nucleotides in length that regulate the expression of target genes post-transcriptionally, and are highly involved in cancer progression. They are able to impact a variety of cell processes such as proliferation, apoptosis and differentiation and can consequently control tumor initiation, tumor progression and metastasis formation. miRNAs can regulate, at the same time, metabolic gene expression which, in turn, influences relevant traits of malignancy such as cell adhesion, migration and invasion. Since the interaction between metabolism and adhesion or cell movement has not, to date, been well understood, in this review, we will specifically focus on miRNA alterations that can interfere with some metabolic processes leading to the modulation of cancer cell movement. In addition, we will analyze the signaling pathways connecting metabolism and adhesion/migration, alterations that often affect cancer cell dissemination and metastasis formation

Le Soprintendenze bibliografiche dello Stato

The intervention sums up the story of the bibliographic Superintendences, ministerial offices funded in 1919 and transferred to the Regions in 1972, and talks about their positioning within the history of the cultural policies from the Italian unification onwards. Sources used have been legislative and regulatory acts, essays on the subject from different periods and written testimonies of sector's operators. The immediate reason for this has been the need to study the development of state and regional policies on this matter when reform interventions deeply modify the balance of the last forty years. The survey has outlined also the persistence of never-solved problems in the planning of public interventions: for example, different functions have been managed by eclectic structures and at the same time the performance of the single functions has been fragmented based on their own institutions