Lateral Exchange of Larval Fish between a Restored Backwater and a Large River in the East-Central USA

Exchange of larval fish between a river\u27s main channel and its floodplain backwaters is compromised by sedimentation. Restoration projects to reduce sediment loading are being implemented in large rivers of the midwestern United States to curb backwater habitat loss and restore backwater-to-river connectivity. During 2004 and 2005, drift nets were set bidirectionally (with and against the flow) within a constructed channel between the Illinois River and an adjacent, 1,100-ha restored backwater, Swan Lake, to investigate the interplay between life history strategies and lateral drift on a diel and seasonal basis. Ambient larval density and species composition within the river and backwater also were quantified. Drift was positively correlated with water velocity in the main stem during 2004, and an estimated 32.3 × 106 larvae drifted at the surface of the channel into Swan Lake. In the absence of a flood in 2005, the density and composition of the larval fish assemblage in Swan Lake and the Illinois River appeared to drive larval drift timing, magnitude, and composition. Swan Lake\u27s restoration has maintained some river connectivity and lateral drift functionality for resident fish, but its functionality compared with natural, connected river–backwater systems remains unknown

The Management of Schizophrenia in Clinical Practice (MOSAIC) Registry: A focus on patients, caregivers, illness severity, functional status, disease burden and healthcare utilization

The Management of Schizophrenia in Clinical Practice (MOSAIC), a disease-based registry of schizophrenia, was initiated in December 2012 to address important gaps in our understanding of the impact and burden of schizophrenia and to provide insight into the current status of schizophrenia care in the US. Recruitment began in December 2012 with ongoing assessment continuing through May 2014. Participants were recruited from a network of 15 centralized Patient Assessment Centers supporting proximal care sites. Broad entry criteria included patients diagnosed with schizophrenia, schizophreniform or schizoaffective disorder, presenting within the normal course of care, in usual treatment settings, aged ≥18years and able to read and speak English. By May 2014, 550 participants (65.8% male, 59.8% White, 64.4% single, mean age 42.9years), were enrolled. The majority had a diagnosis of schizophrenia (62.0%). Mean illness duration at entry was 15.0years. Common comorbidities at entry were high lipid levels (26.9%), hypertension (23.1%) and type II diabetes (13%). Participants were categorized by baseline overall Clinical Global Impression—Schizophrenia Severity Score as minimally (9.1%), mildly (25.3%), moderately (39.9%), markedly (22.3%) and severely (3.4%) ill. Most commonly used second generation antipsychotics at entry were risperidone (17.8%), clozapine (16.5%), olanzapine (14.0%), aripiprazole (13.6%) and quetiapine (5.6%). No large-scale patient registry has been conducted in the US to longitudinally follow patients with schizophrenia and describe symptom attributes, support network, care access and disease burden. These data provide important epidemiological, clinical and outcome insights into the burden of schizophrenia in the US