14 research outputs found
A Randomized Controlled Study of Low-Dose Hydrocortisone Versus Placebo in Dopamine-Treated Hypotensive Neonates Undergoing Hypothermia Treatment for Hypoxic−Ischemic Encephalopathy
A New System for Studying Spatial Front Instabilities: The Supercatalytic Chlorite–Trithionate Reaction
Kinetics and Mechanism of the Oxidation of Pentathionate Ion by Chlorine Dioxide in a Slightly Acidic Medium
Integrated spatial assessment of inland excess water hazard on the Great Hungarian Plain
Sustained Large-Amplitude Chemomechanical Oscillations Induced by the Landolt Clock Reaction
International audienceSynergetic chemomechanical oscillators represent a fundamentally new class of oscillators, where a clock reaction, owning no oscillatory chemical kinetics, generates shrinking−swelling cycles in a chemoresponsive gel under appropriate fixed nonequilibrium boundary conditions. Sufficiently large size-changes are a condition for continually switching between a reacted and an unreacted chemical state in the gel through sufficiently large differences in the diffusion time between the environment and the core of the gel. Two former experimental demonstrations with acid autocatalytic reactions were frustrated either by complex behaviors (chlorite−tetrathionate system) or by side reactions with the gel matrix (bromate−sulfite system)....
Study on the Reduction Properties of Thiourea Dioxide and Its Application in Discharge Printing of Polyester Fabrics
Integrated spatial assessment of inland excess water hazard on the Great Hungarian Plain
New poly(ADP-Ribose) Polymerase-1 Inhibitors with Antioxidant Activity Based on 4-Carboxamidobenzimidazole-2-yl-pyrroline and -tetrahydropyridine Nitroxides and their Precursors
4-Carboxamidobenzimidazoles were previously described as PARP inhibitor compounds. Here we report upon 4-carboxamido-1H-benzimidazoles substituted in the 2-position with nitroxides or their amine or hydroxylamine precursors. Among the new molecules, a highly active PARP inhibitor 4h (IC50 = 14 nM) was identified with antioxidant/radical scavenger activity. We concluded that in most cases sterically-hindered amines are better PARP inhibitors than their oxidized form and structural changes in the 2-substituted-4-carboxamido-1H-benzimidazoles, (such as N-substitution, or changing the position of the carboxamide group) was detrimental to PARP inhibition activity, but not on antioxidant activity. These results indicate the advantages in combining of an antioxidant nitroxide or nitroxide precursor with a PARP inhibitor molecule to decrease or eliminate the deleterious processes initiated by reactive oxygen and reactive nitrogen species (ROS and RNS). The radical scavenging capability of 4h was demonstrated by EPR study of urine collected after drug administration