1 research outputs found
Progesterone, progesterone/estradiol and ART outcomes in day-5 transfer cycles
<p>The objective of this study was to assess the effects of elevated luteal-phase progesterone levels (PE) and high progesterone/estradiol ratio (βP/E2β ratio) on IVF outcomes, exclusively in GnRH-antagonist cycles with day-5 embryo transfer. PE was not found to have a significant effect on implantation or clinical pregnancy rate (CPR) (OR 0.56, 95% CI 0.25β1.25, <i>p</i>β=β.16). Elevated βP/E2β ratio (β₯0.55) on trigger day was associated with a poorer response to stimulation and lower clinical pregnancy rates (OR 0.58, 95% CI 0.34β1.00, <i>p</i>β=β.05). Patients with PE and low βP/E2β ratio yielded significantly more oocytes than patients with PE and high βP/E2β ratio. The mean implantation rate per patient decreased by 60% in the group with PE and high βP/E2β ratio in comparison to the group with PE and low βP/E2β ratio (17.9%Β±36.6 vs. 45.5%Β±47.2, <i>p</i>β=β.06), although no statistical significance was observed. The detrimental effect of PE may be mitigated by culturing embryos to day-5 before embryo transfer. Combined assessment of serum progesterone and βP/E2β ratio may predict pregnancy outcome better than progesterone levels alone.</p