Interação medicamentosa: conhecimento de enfermeiros das unidades de terapia intensiva Interacción medicamentosa: conocimiento de enfermeros de las unidades de cuidados intensivos Medication interaction: knowledge of nurses in intensive care units

OBJETIVO: Avaliar o conhecimento das interações medicamentosas (IM)de enfermeiros que atuam em unidades de terapia intensiva de adultos, de três hospitais públicos de Goiás. MÉTODOS: Estudo descritivo, transversal. População 64 e amostra, 51 enfermeiros. Construiu-se um instrumento de coleta de dados, utilizando informações da base de dados MICROMEDEX®. RESULTADOS: Sobre o conhecimento de IM e manejo clínico, houve uma relação de acertos e erros de, aproximadamente, 50% dos enfermeiros. As duplas de medicamentos que os enfermeiros mais acertaram foram relativas a medicamentos com ação sedativa e analgésica e as que apresentaram mais erros, foram as de ação anti-infecciosa e anti-hipertensiva. CONCLUSÃO: É necessário sensibilizar autoridades e profissionais sobre a importância das IM na UTI e implementar ações para a segurança dos pacientes na terapêutica medicamentosa.<br>OBJETIVO: Evaluar el conocimiento de las interacciones medicamentosas (IM) de enfermeros que actúan en unidades de cuidados intensivos de adultos, de tres hospitales públicos de Goiás. MÉTODOS: Estudio descriptivo, transversal. Población 64 y muestra 51 enfermeros. Se construyó un instrumento de recolección de datos, utilizando informaciones de la base de datos MICROMEDEX®. RESULTADOS: Sobre el conocimiento de IM y manejo clínico, hubo una relación de aciertos y errores de, aproximadamente el 50% de los enfermeros. El par de medicamentos que los enfermeros aciertan más fueron los relativos a medicamentos con acción sedante y analgésica y los que presentaron más errores, fueron los de acción anti-infecciosa y anti-hipertensiva. CONCLUSIÓN: Es necesario sensibilizar a las autoridades y profesionales sobre la importancia de las IM en la UCI e implementar acciones para la seguridad de los pacientes en la terapéutica medicamentosa.<br>OBJECTIVE: To evaluate adult intensive care unit (ICU) nurses' knowledge of medication interactions (IM) in three public hospitals in Goias. METHODS: A cross-sectional study was conducted using a population of 64 and a sample of 51 nurses. An instrument was constructed to collect data, using information from the database MICROMEDEX ®. RESULTS: Regarding the knowledge of clinical management of IM, there was approximately the same number of right and wrong answers among 50% of the nurses. Nurses had better knowledge about drugs with sedative and analgesic action; nurses demonstrated less knowledge about drugs with anti-infective and anti-hypertensive actions. CONCLUSION: It is necessary to sensitize the authorities and professionals about the importance of IM in the ICU, and to implement actions for patient safety related to drug therapy

Prevalence of drug–drug interactions in geriatric patients at an ambulatory care pharmacy in a tertiary care teaching hospital

Abstract Objective A cross-sectional study was performed from February to May 2015, to estimate the prevalence of drug–drug interactions in geriatric patients at the ambulatory care pharmacy at King Abdul-Aziz Medical City in Jeddah, Saudi Arabia. Results A total of 310 patients were included, with a mean age (± SD) of 73.78 ± 6.96, and 48.70% were female. The overall prevalence of DDIs of all categories was 90.64%. Category B DDIs was 55.80%, category C DDIs 87.74%, category D DDIs 51.93%, and category X DDIs 16.45%. Atorvastatine plus omeprazole was identified as the most common interacting pair, with a prevalence of 25.26%. Multivariate logistic regression analysis showed that category D or X DDIs are more likely to occur in the female patient (OR = 1.79; 95% CI 1.07, 2.97), the patient taking more than three medications (OR = 22.62; 95% CI 2.93, 174.83), and the patient with more than two conditions (OR = 3.09; 95% CI 1.81, 5.27)