176 research outputs found

    U-Pb Zircon Geochronology of Roxbury Conglomerate, Boston Basin, Massachusetts: Tectono-stratigraphic Implications for Avalonia in and Beyond SE New England

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    High-precision CA-TIMS 206Pb/238U zircon dates from sandstone and Brighton igneous rocks associated with Roxbury Conglomerate in the Boston Basin, eastern Massachusetts provide constraints on the age and tectonic significance of these deposits. Detrital zircon suites from Roxbury-related sandstones representing, in ascending order, the Franklin Park Member (proposed name), the Brookline Member and the Squantum Member establish closely comparable maximum depositional ages of 595.14 ± 0.90, 598.87 ± 0.71 and 596.39 ± 0.79 Ma, respectively. The youngest of these is the best maximum age estimate of the conglomerate. Brighton dacite near the base of the Brookline Member and amygdaloidal andesite near the top yield respective crystallization ages of 584.19 ± 0.70 Ma and 585.37 ± 0.72 Ma. These virtually identical dates support previous interpretations of these particular units as shallow intrusions and thus represent minimum ages of associated conglomerate. The Roxbury-Brighton sequence is traditionally shown as inter-fingering northward with ≤570 Ma mudstone of the Cambridge “Argillite,” but the age range of the conglomerate makes this impossible. Conglomerate lacking quartzite clasts typical of the Roxbury proper and associated with 593.19 ± 0.73 Ma rhyolite on the south side of the basin is re-assigned to the Lynn-Mattapan Volcanic Complex which rests unconformably on Dedham Granite in basement exposed west and north of the basin as well. Calc-alkaline geochemistry and ages of the 609 to 584 Ma Dedham-Lynn-Mattapan-Brighton assemblage link it with 630 to 580 Ma arc sequences in other northern Appalachian Avalonian terranes. Roxbury Conglomerate accumulated in fault-bounded intra-arc basins near the end of this magmatic cycle

    The federal budget

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    This item was digitized by the Internet Archive. Thesis (M.A.)--Boston Universityhttps://archive.org/details/thefederalbudget00cro

    Vision self-management for older adults: a randomised controlled trial

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    Background/aims: Ageing of the population will result in unprecedented numbers of older adults living with age-related vision loss (ARVL). Self-management models improve health outcomes and reduce healthcare costs; however, the principles have rarely been applied in low vision services. Methods: A two-armed randomised controlled trial of older adults (n=77) with ARVL compared ‘usual care’ provided by a not-for-profit community agency with an extended model of care (usual care+self-management group intervention). The primary outcome variable (participation in life situations) was measured using the Activity Card Sort. Secondary outcome measures examined general health and vision-specific domains.Results: The intention-to-treat analysis demonstrated that the extended model produced significantly better participation in life situations at post-test when compared with the usual care only group. Gains were made regardless of whether participants were, or were not, depressed at baseline. The addition of the self-management group was also successful in significantly reducing depression, increasing physical and mental health, generalised and domain-specific self-efficacy, and adjustment to ARVL. With the exception of adjustment and mental health, differences were still apparent at 12 weeks' follow-up. Conclusion: Addition of self-management significantly improved general health and vision-specific rehabilitation outcomes for older adults with ARVL

    Mind the Gap: How Interspecies Variability in IgG and Its Receptors May Complicate Comparisons of Human and Non-human Primate Effector Function

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    The field of HIV research relies heavily on non-human primates, particularly the members of the macaque genus, as models for the evaluation of candidate vaccines and monoclonal antibodies. A growing body of research suggests that successful protection of humans will not solely rely on the neutralization activity of an antibody's antigen binding fragment. Rather, immunological effector functions prompted by the interaction of the immunoglobulin G constant region and its cognate Fc receptors help contribute to favorable outcomes. Inherent differences in the sequences, expression, and activities of human and non-human primate antibody receptors and immunoglobulins have the potential to produce disparate results in the observations made in studies conducted in differing species. Having a more complete understanding of these differences, however, should permit the more fluent translation of observations between model organisms and the clinic. Here we present a guide to such translations that encompasses not only what is presently known regarding the affinity of the receptor-ligand interactions but also the influence of expression patterns and allelic variation, with a focus on insights gained from use of this model in HIV vaccines and passive antibody therapy and treatment

    Vision Self-Mmanagement For Older Adults: a Randomised Controlled Trial

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    Background/aims Ageing of the population will result in unprecedented numbers of older adults living with age-related vision loss (ARVL). Self-management models improve health outcomes and reduce healthcare costs; however, the principles have rarely been applied in low vision services. Methods A two-armed randomised controlled trial of older adults (n=77) with ARVL compared ‘usual care’ provided by a not-for-profit community agency with an extended model of care (usual care+self-management group intervention). The primary outcome variable (participation in life situations) was measured using the Activity Card Sort. Secondary outcome measures examined general health and vision-specific domains. Results The intention-to-treat analysis demonstrated that the extended model produced significantly better participation in life situations at post-test when compared with the usual care only group. Gains were made regardless of whether participants were, or were not, depressed at baseline. The addition of the self-management group was also successful in significantly reducing depression, increasing physical and mental health, generalised and domain-specific self-efficacy, and adjustment to ARVL. With the exception of adjustment and mental health, differences were still apparent at 12 weeks\u27 follow-up. Conclusion Addition of self-management significantly improved general health and vision-specific rehabilitation outcomes for older adults with ARVL

    Prevalence of blindness in Western Australia: a population study using capture and recapture techniques

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    Aim: To determine the prevalence of blinding eye disease in Western Australia using a capture and recapture methodology. Methods: Three independent lists of residents of Western Australia who were also legally blind were collated during the capture periods in 2008–9. The first list was obtained from the state-wide blind register. A second list comprised patients routinely attending hospital outpatient eye clinics over a 6-month period in 2008. The third list was patients attending ophthalmologists' routine clinical appointments over a 6-week period in 2009. Lists were compared to identify those individuals who were captured on each list and those who were recaptured by subsequent lists. Log-linear models were used to calculate the best fit and estimate the prevalence of blindness in the Western Australian population and extrapolated to a national prevalence of blindness in Australia. Results: 1771 legally blind people were identified on three separate lists. The best estimate of the prevalence of blindness in Western Australia was 3384 (95% CI 2947 to 3983) or 0.15% of the population of 2.25 million. Extrapolating to the national population (21.87 million) gave a prevalence of legal blindness of approximately 32 892 or 0.15%. Conclusion: Capture–recapture techniques can be used to determine the prevalence of blindness in whole populations. The calculated prevalence of blindness suggested that up to 30% of legally blind people may not be receiving available financial support and up to 60% were not accessing rehabilitation services

    Pharmacy students' experience of technology-enhanced learning during the COVID-19 pandemic

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    With the advent of the COVID-19 pandemic, pharmacy students and educators experienced an abrupt shift as programmes that were previously taught exclusively in-person were then predominantly taught online. This sudden change provided little time for students to prepare for the new learning environment. The study objective was to explore pharmacy students' experiences of technology-enhanced learning during the COVID-19 pandemic. A cross-sectional survey was developed and distributed by email to all 3rd year (N = 76) and 4th year (N = 68) pharmacy students undertaking an MPharm programme in an Irish university. A total of 32 responses were collected, including 20 third year and 12 fourth year pharmacy students (response rates of 26.3% and 17.6%, respectively). The majority of respondents reported good or very good internet speed (71%) and stability (59%). Almost all were confident or very confident using Canvas (97%) prior to the onset of online learning. Respondents preferred engaging with other students in-person rather than online for coursework (68.8%) and learning new material (56.3%). Students favoured face-to-face delivery, with a recording of the session available online afterwards, for lectures (68.8%), workshops (50%) and tutorials (56.3%). Analysis of free-text comments indicates that respondents used recorded content to support exam revision and that a key drawback of online learning was social isolation. Pharmacy students favoured a blended learning approach, with in-person learning being recorded to support study and revision. Students' experience of TEL during the pandemic should be considered in the development and ongoing review of pharmacy programmes

    Project AIM: Autism Intervention Meta-Analysis for Studies of Young Children

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    Article is forthcoming as of December 2019. Citation for published version will be added once released by the American Psychological Association.In this comprehensive systematic review and meta-analysis of group design studies of nonpharmacological early interventions designed for young children with autism spectrum disorder (ASD), we report summary effects across seven early intervention types (behavioral, developmental, naturalistic developmental behavioral intervention [NDBI], TEACCH, sensory-based, animal-assisted, and technology-based), and 15 outcome categories indexing core and related ASD symptoms. A total of 1,615 effect sizes were gathered from 130 independent participant samples. A total of 6,240 participants, who ranged in age from 0-8 years, are represented across the studies. We synthesized effects within intervention and outcome type using a robust variance estimation approach to account for the nesting of effect sizes within studies. We also tracked study quality indicators, and report an additional set of summary effect sizes that restrict included studies to those meeting pre-specified quality indicators. Finally, we conducted moderator analyses to evaluate whether summary effects across intervention types were larger for proximal as compared to distal effects, and for context-bound as compared to generalized effects. We found that when study quality indicators were not taken into account, significant positive effects were found for behavioral, developmental, and NDBI intervention types. When effect size estimation was limited to studies with randomized controlled trial (RCT) designs, evidence of positive summary effects existed only for developmental and NDBI intervention types. This was also the case when outcomes measured by parent report were excluded. Finally, when effect estimation was limited to RCT designs and to outcomes for which there was no risk of detection bias, no intervention types showed significant effects on any outcome.Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) of the National Institutes of Health (U54HD083211; PI: Neul)Special Educatio
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