45 research outputs found
Moral tales of parental living kidney donation: a parenthood moral imperative and its relevance for decision making
Current concepts and future of noninvasive procedures for diagnosing oral squamous cell carcinoma - a systematic review
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Improving the agent-based simulation of major incident response in the United Kingdom through conceptual and operational validation
Online Optimization of Casualty Processing in Major Incident Response: An Experimental Analysis
Agent-based simulation of emergency response to plan the allocation of resources for a hypothetical two-site major incident
THE IMPACT OF PEER INSTRUCTION ON COLLEGE STUDENTS’ BELIEFS ABOUT PHYSICS AND CONCEPTUAL UNDERSTANDING OF ELECTRICITY AND MAGNETISM
Radical subjects after hegemony
This article explores a contemporary problem pertaining to the progressive political projects of anti-racism, feminism, gay rights and green politics. It tackles the complex and conflicted situation whereby these once thoroughly oppositional projects now appear to occupy a hegemonic position, and suggests that this has paradoxically led to the demise of radical subject positions. I consider how progressive discourses have effectively become ‘detached’ from participatory social movements that once served as both their progenitors and guarantors, and address the problem of conceptual inertia, whereby discourses appropriated and modified by the political right and mainstream continue to signify an ‘original’ meaning, thus serving to bolster the moral legitimacy of their self-declared champions and defend them against critique. Rather than dismiss this mainstreaming as simply a betrayal, I stress that it describes a new terrain of political struggle that cannot be predicated on a nostalgia for radical subjects as we have historically tended to imagine them