Folk and Popular Music of Brazil

Both general interest in Brazilian popular music in North America and pertinent research agendas in Brazil and abroad have led to varied new publications. In the musical arena itself, vital new phenomena have appeared, and international attention to Brazil\u27s popular music has significantly increased. As far as sound recording is concerned, the past decade has witnessed the consolidation of the digital age, and the CD has become the preferred vehicle, though the limited buying power of the bulk of the Brazilian population has determined the continued mass manufacture of cassette tapes as well as vinyl LPs in Brazil. In sum, changing conditions of production and consumption, fresh ideas and styles in music-making, and on-going efforts in scholarship, all validate the present revised and expanded edition of the specialized bibliography

Homologous recombination DNA repair defects in PALB2- associated breast cancers

Abstract: Mono-allelic germline pathogenic variants in the Partner And Localizer of BRCA2 (PALB2) gene predispose to a high-risk of breast cancer development, consistent with the role of PALB2 in homologous recombination (HR) DNA repair. Here, we sought to define the repertoire of somatic genetic alterations in PALB2-associated breast cancers (BCs), and whether PALB2-associated BCs display bi-allelic inactivation of PALB2 and/or genomic features of HR-deficiency (HRD). Twenty-four breast cancer patients with pathogenic PALB2 germline mutations were analyzed by whole-exome sequencing (WES, n = 16) or targeted capture massively parallel sequencing (410 cancer genes, n = 8). Somatic genetic alterations, loss of heterozygosity (LOH) of the PALB2 wild-type allele, large-scale state transitions (LSTs) and mutational signatures were defined. PALB2-associated BCs were found to be heterogeneous at the genetic level, with PIK3CA (29%), PALB2 (21%), TP53 (21%), and NOTCH3 (17%) being the genes most frequently affected by somatic mutations. Bi-allelic PALB2 inactivation was found in 16 of the 24 cases (67%), either through LOH (n = 11) or second somatic mutations (n = 5) of the wild-type allele. High LST scores were found in all 12 PALB2-associated BCs with bi-allelic PALB2 inactivation sequenced by WES, of which eight displayed the HRD-related mutational signature 3. In addition, bi-allelic inactivation of PALB2 was significantly associated with high LST scores. Our findings suggest that the identification of bi-allelic PALB2 inactivation in PALB2-associated BCs is required for the personalization of HR-directed therapies, such as platinum salts and/or PARP inhibitors, as the vast majority of PALB2-associated BCs without PALB2 bi-allelic inactivation lack genomic features of HRD

Delivering affordable housing through the planning system in urban renewal contexts: converging government roles in Queensland, South Australia and New South Wales

This paper outlines the current Australian policy environment for delivering affordable housing in urban renewal contexts. An increasing shift towards infill development, coupled with a decreasing provision of government owned social housing, is placing severe pressure on housing affordability. The cumulative effect is to create the need for governments to intervene on urban renewal projects to ensure that affordable housing options are delivered as a part of any new development. Three different approaches to planning for affordable housing in three states are examined: the former Urban Land Development Authority in Queensland, the 15% inclusionary zoning requirement in South Australia and the Affordable Rental Housing State Environmental Planning Policy in New South Wales. Despite significant differences between these approaches, a number of potential roles emerge for government to support delivery of affordable housing by market and not-for-profit housing providers, without adversely affecting development viability. These roles are as the land facilitator, educator, risk taker, subsidiser and long-term planner. Given that one aim of current policy directions is to reduce the role of government in delivering housing and urban growth, the paper concludes by considering the extent to which the approaches across the three states studied can be considered successful