309 research outputs found
Dynamical Coulomb blockade of multiple Andreev reflections
We analyze the dynamical Coulomb blockade of multiple Andreev reflections
(MAR) in a superconducting quantum point contact coupled to a macroscopic
impedance. We find that at very low transmission the blockade scales as
with , where is the bias voltage and is the
superconducting gap, as it would correspond to the occurrence of "shots" of
charge . For higher transmission the blockade is reduced both due to Pauli
principle and to elastic renormalization of the MAR probability, and for
certain voltage regions it may even become an "antiblockade", i.e. the current
is enhanced due to the coupling with the electromagnetic environment.Comment: 5 pages, 4 figures, submitted to Phys. Rev. Let
Direct link between Coulomb blockade and shot noise in a quantum coherent structure
We analyze the current-voltage characteristic of a quantum conduction channel
coupled to an electromagnetic environment of arbitrary frequency-dependent
impedance. In the weak blockade regime the correction to the ohmic behavior is
directly related to the channel current fluctuations vanishing at perfect
transmission in the same way as shot noise. This relation can be generalized to
describe the environmental Coulomb blockade in a generic mesoscopic conductor
coupled to an external impedance, as the response of the latter to the current
fluctuations in the former.Comment: 12 pages, 2 figures, submitted to Phys. Rev. Let
Inelastic Interaction Corrections and Universal Relations for Full Counting Statistics
We analyze in detail the interaction correction to Full Counting Statistics
(FCS) of electron transfer in a quantum contact originating from the
electromagnetic environment surrounding the contact. The correction can be
presented as a sum of two terms, corresponding to elastic/inelastic electron
transfer. Here we primarily focus on the inelastic correction.
For our analysis, it is important to understand more general -- universal --
relations imposed on FCS only by quantum mechanics and statistics with no
regard for a concrete realization of a contact. So we derive and analyze these
relations. We reveal that for FCS the universal relations can be presented in a
form of detailed balance. We also present several useful formulas for the
cumulants.
To facilitate the experimental observation of the effect, we evaluate
cumulants of FCS at finite voltage and temperature. Several analytical results
obtained are supplemented by numerical calculations for the first three
cumulants at various transmission eigenvalues.Comment: 10 pages, 3 figure
Production of Interferons and β-Chemokines by Placental Trophoblasts of HIV-1-Infected Women
Objective: The mechanism whereby the placental cells of a human immunodeficiency virus (HIV)-1-infected mother protect the fetus from HIV-1 infection is unclear. Interferons (IFNs) inhibit the replication of viruses by acting at various stages of the life cycle and may play a role in protecting against vertical transmission of HIV-1. In addition the β-chemokines RANTES (regulated on activation T cell expressed and secreted), macrophage inflammatory protein-1-α (MIP-1α), and MIP-1β can block HIV-1 entry into cells by preventing the binding of the macrophage-trophic HIV-1 strains to the coreceptorCCR5. In this study the production of IFNs and β-chemokines by placental trophoblasts of HIV-1-infected women who were HIV-1 non-transmitters was examined. Methods: Placental trophoblastic cells were isolated from 29 HIV-1-infected and 10 control subjects. Supernatants of trophoblast cultures were tested for the production of IFNs and β-chemokines by enzyme linked immunosorbent assay (ELISA). Additionally, HIV-1-gag and IFN-β transcripts were determined by a semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) assay. Results: All placental trophoblasts of HIV-1-infected women contained HIV-1-gag transcripts. There were no statistical differences in the median constitutive levels of IFN-α and IFN-γ produced by trophoblasts of HIV-1- infected and control subjects. In contrast, trophoblasts of HIV-1-infected women constitutively produced significantly higher levels of IFN-β protein than trophoblasts of control subjects. Furthermore, the median levels of β-chemokines produced by trophoblasts of HIV-infected and control women were similar. Conclusions: Since there was no correlation between the placental HIV load and the production of interferons or β-chemokines, the role of trophoblast-derived IFNs and β-chemokines in protecting the fetus from infection with HIV-1 is not clear
The number of transmission channels through a single-molecule junction
We calculate transmission eigenvalue distributions for Pt-benzene-Pt and
Pt-butadiene-Pt junctions using realistic state-of-the-art many-body
techniques. An effective field theory of interacting -electrons is used to
include screening and van der Waals interactions with the metal electrodes. We
find that the number of dominant transmission channels in a molecular junction
is equal to the degeneracy of the molecular orbital closest to the metal Fermi
level.Comment: 9 pages, 8 figure
Subharmonic Shapiro steps and assisted tunneling in superconducting point contacts
We analyze the current in a superconducting point contact of arbitrary
transmission in the presence of a microwave radiation. The interplay between
the ac Josephson current and the microwave signal gives rise to Shapiro steps
at voltages V = (m/n) \hbar \omega_r/2e, where n,m are integer numbers and
\omega_r is the radiation frequency. The subharmonic steps (n different from 1)
are a consequence of the ocurrence of multiple Andreev reflections (MAR) and
provide an unambiguous signature of the peculiar ac Josephson effect at high
transmission. Moreover, the dc current exhibits a rich subgap structure due to
photon-assisted MARs.Comment: Revtex, 4 pages, 4 figure
Corticosteroid-induced spinal epidural lipomatosis in the pediatric age group: report of a new case and updated analysis of the literature
Spinal epidural lipomatosis is a rare complication of chronic corticosteroid treatment. We report a new pediatric case and an analysis of this and 19 pediatric cases identified in the international literature. The youngest of these combined 20 patients was 5 years old when lipomatosis was diagnosed. Lipomatosis manifested after a mean of 1.3 (+/- 1.5) years (SD) (median, 0.8 years; range, 3 weeks - 6.5 years) of corticosteroid treatment. The corticosteroid dose at the time of presentation of the lipomatosis ranged widely, between 5 and 80 mg of prednisone/day. Back pain was the most common presenting symptom. Imaging revealed that lipomatosis almost always involved the thoracic spine, extending into the lumbosacral region in a subset of patients. Predominantly lumbosacral involvement was documented in only two cases. Although a neurological deficit at presentation was documented in about half of the cases, surgical decompression was not performed in the cases reported after 1996. Instead, reducing the corticosteroid dose (sometimes combined with dietary restriction to mobilize fat) sufficed to induce remission. In summary, pediatric spinal epidural lipomatosis remains a potentially serious untoward effect of corticosteroid treatment, which, if recognized in a timely manner, can have a good outcome with conservative treatment
Dorsal muscle group area and surgical outcomes in liver transplantation
Introduction Better measures of liver transplant risk stratification are needed. Our previous work noted a strong relationship between psoas muscle area and survival following liver transplantation. The dorsal muscle group is easier to measure, but it is unclear if they are also correlated with surgical outcomes. Methods Our study population included liver transplant recipients with a preoperative CT scan. Cross‐sectional areas of the dorsal muscle group at the T12 vertebral level were measured. The primary outcomes for this study were one‐ and five‐yr mortality and one‐yr complications. The relationship between dorsal muscle group area and post‐transplantation outcome was assessed using univariate and multivariate techniques. Results Dorsal muscle group area measurements were strongly associated with psoas area ( r = 0.72; p < 0.001). Postoperative outcome was observed from 325 patients. Multivariate logistic regression revealed dorsal muscle group area to be a significant predictor of one‐yr mortality (odds ratio [ OR ] = 0.53, p = 0.001), five‐yr mortality ( OR = 0.53, p < 0.001), and one‐yr complications ( OR = 0.67, p = 0.007). Conclusion Larger dorsal muscle group muscle size is associated with improved post‐transplantation outcomes. The muscle is easier to measure and may represent a clinically relevant postoperative risk factor.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109316/1/ctr12422.pd
Preoperative Psoas Muscle Size Predicts Postoperative Delirium in Older Adults Undergoing Surgery: A Pilot Cohort Study
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/136001/1/jgs14571.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/136001/2/jgs14571_am.pd
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