Leishmaniasis: new approaches to disease control.

The leishmaniases afflict the world's poorest populations. Among the two million new cases each year in the 88 countries where the disease is endemic (fig 1), it is estimated that 80% earn less than $2 a day. Human infections with Leishmania protozoan parasites, transmitted via the bite of a sandfly, cause visceral, cutaneous, or mucocutaneous leishmaniasis. The global burden of leishmaniasis has remained stable for some years, causing 2.4 million disability adjusted life years (DALYs) lost and 59 000 deaths in 2001. Neglected by researchers and funding agencies, leishmaniasis control strategies have varied little for decades, but in recent years there have been exciting advances in diagnosis, treatment, and prevention. These include an immunochromatographic dipstick for diagnosing visceral leishmaniasis; the licensing of miltefosine, the first oral drug for visceral leishmaniasis; and evidence that the incidence of zoonotic visceral leishmaniasis in children can be reduced by providing dogs with deltamethrin collars. There is also hope that the first leishmaniasis vaccine will become available within a decade. Here we review these developments and identify priorities for research

Predictive learning, prediction errors, and attention: evidence from event-related potentials and eye tracking

Prediction error (‘‘surprise’’) affects the rate of learning: We learn more rapidly about cues for which we initially make incorrect predictions than cues for which our initial predictions are correct. The current studies employ electrophysiological measures to reveal early attentional differentiation of events that differ in their previous involvement in errors of predictive judgment. Error-related events attract more attention, as evidenced by features of event-related scalp potentials previously implicated in selective visual attention (selection negativity, augmented anterior N1). The earliest differences detected occurred around 120 msec after stimulus onset, and distributed source localization (LORETA) indicated that the inferior temporal regions were one source of the earliest differences. In addition, stimuli associated with the production of prediction errors show higher dwell times in an eyetracking procedure. Our data support the view that early attentional processes play a role in human associative learning

Cosmological Limits on the Neutrino Mass from the Lya Forest

The Lya forest in quasar spectra probes scales where massive neutrinos can strongly suppress the growth of mass fluctuations. Using hydrodynamic simulations with massive neutrinos, we successfully test techniques developed to measure the mass power spectrum from the forest. A recent observational measurement in conjunction with a conservative implementation of other cosmological constraints places upper limits on the neutrino mass: m_nu < 5.5 eV for all values of Omega_m, and m_nu < 2.4 (Omega_m/0.17 -1) eV, if 0.2 < Omega_m <0.5 as currently observationally favored (both 95 % C.L.).Comment: 4 pages, 2 ps figures, REVTex, submitted to Phys. Rev. Let

Simulating the effects of intergalactic gray dust

Using a high-resolution cosmological hydrodynamic simulation, we present a method to constrain extinction due to intergalactic gray dust based on the observed magnitudes of distant Type Ia supernovae. We apply several simple prescriptions to relate the intergalactic dust density to the gas density in the simulation, thereby obtaining dust extinctions that may be directly compared with the observed distribution of supernova magnitudes. Our analysis is sensitive to the spatial distribution of gray dust but is not dependent on its intrinsic properties, such as its opacity or grain size. We present an application of our technique to the supernova data of Perlmutter et al., who find that their high-redshift sample is ~0.2 mag fainter than the expectation for a nonaccelerating, low-density universe. We find that for gray dust to be responsible, it must be distributed quite smoothly (e.g., tracing intergalactic gas). More realistic dust distributions, such as dust tracing the metal density, are inconsistent with observations at the 1.5-2 σ level. Upcoming observations and improved modeling of the dust distribution should lead to stronger constraints on intergalactic gray dust extinction

Utterance Selection Model of Language Change

We present a mathematical formulation of a theory of language change. The theory is evolutionary in nature and has close analogies with theories of population genetics. The mathematical structure we construct similarly has correspondences with the Fisher-Wright model of population genetics, but there are significant differences. The continuous time formulation of the model is expressed in terms of a Fokker-Planck equation. This equation is exactly soluble in the case of a single speaker and can be investigated analytically in the case of multiple speakers who communicate equally with all other speakers and give their utterances equal weight. Whilst the stationary properties of this system have much in common with the single-speaker case, time-dependent properties are richer. In the particular case where linguistic forms can become extinct, we find that the presence of many speakers causes a two-stage relaxation, the first being a common marginal distribution that persists for a long time as a consequence of ultimate extinction being due to rare fluctuations.Comment: 21 pages, 17 figure

Line versus Flux Statistics -- Considerations for the Low Redshift Lyman-alpha Forest

The flux/transmission power spectrum has become a popular statistical tool in studies of the high redshift ($z > 2$) Lyman-alpha forest. At low redshifts, where the forest has thinned out into a series of well-isolated absorption lines, the motivation for flux statistics is less obvious. Here, we study the relative merits of flux versus line correlations, and derive a simple condition under which one is favored over the other on purely statistical grounds. Systematic errors probably play an important role in this discussion, and they are outlined as well.Comment: 6 pages, to appear in "The IGM/Galaxy Connection: The Distribution of Baryons at z=0", eds. J. L. Rosenberg and M. E. Putma

Cultural selection drives the evolution of human communication systems

Human communication systems evolve culturally, but the evolutionary mechanisms that drive this evolution are not well understood. Against a baseline that communication variants spread in a population following neutral evolutionary dynamics (also known as drift models), we tested the role of two cultural selection models: coordination- and content-biased. We constructed a parametrized mixed probabilistic model of the spread of communicative variants in four 8-person laboratory micro-societies engaged in a simple communication game. We found that selectionist models, working in combination, explain the majority of the empirical data. The best-fitting parameter setting includes an egocentric bias and a content bias, suggesting that participants retained their own previously used communicative variants unless they encountered a superior (content-biased) variant, in which case it was adopted. This novel pattern of results suggests that (i) a theory of the cultural evolution of human communication systems must integrate selectionist models and (ii) human communication systems are functionally adaptive complex systems

Comet 9P/Tempel 1: Interpretation with the Deep Impact Results

According to our common understandings, the original surface of a short-period comet nucleus has been lost by sublimation processes during its close approaches to the Sun. Sublimation results in the formation of a dust mantle on the retreated surface and in chemical differentiation of ices over tens or hundreds of meters below the mantle. In the course of NASA's Deep Impact mission, optical and infrared imaging observations of the ejecta plume were conducted by several researchers, but their interpretations of the data came as a big surprise: (1) The nucleus of comet 9P/Tempel 1 is free of a dust mantle, but maintains its pristine crust of submicron-sized carbonaceous grains; (2) Primordial materials are accessible already at a depth of several tens of cm with abundant silicate grains of submicrometer sizes. In this study, we demonstrate that a standard model of cometary nuclei explains well available observational data: (1) A dust mantle with a thickness of ~1-2 m builds up on the surface, where compact aggregates larger than tens of micrometers dominate; (2) Large fluffy aggregates are embedded in chemically differentiated layers as well as in the deepest part of the nucleus with primordial materials. We conclude that the Deep Impact results do not need any peculiar view of a comet nucleus.Comment: 11 pages, 1 figure, 1 table. ApJ letters, 673, L199-20

Warm-Hot Gas in and around the Milky Way: Detection and Implications of OVII Absorption toward LMC X-3

X-ray absorption lines of highly-ionized species such as OVII at about zero redshift have been firmly detected in the spectra of several active galactic nuclei. However, the location of the absorbing gas remains a subject of debate. To separate the Galactic and extragalactic contributions to the absorption, we have obtained Chandra LETG-HRC and FUSE observations of the black hole X-ray binary LMC X--3. A joint analysis of the detected OVII and Ne IX Kalpha lines, together with the non-detection of the OVII Kbeta and OVIII Kalpha lines, gives the measurements of the temperature, velocity dispersion, and hot oxygen column density. The X-ray data also allow us to place a 95% confidence lower limit to the Ne/O ratio as 0.14. The OVII line centroid and its relative shift from the Galactic OI Kalpha absorption line, detected in the same observations, are inconsistent with the systemic velocity of LMC X--3 ($+310 {\rm km s^{-1}}$). The far-UV spectrum shows OVI absorption at Galactic velocities, but no OVI absorption is detected at the LMC velocity at $> 3\sigma$ significance. Both the nonthermal broadening and the decreasing scale height with the increasing ionization state further suggest an origin of the highly-ionized gas in a supernova-driven galactic fountain. In addition, we estimate the warm and hot electron column densities from our detected OVII Kalpha line in the LMC X--3 X-ray spectra and from the dispersion measure of a pulsar in the LMC vicinity. We then infer the O/H ratio of the gas to be $\gtrsim 8 \times 10^{-5}$, consistent with the chemically-enriched galactic fountain scenario. We conclude that the Galactic hot interstellar medium should in general substantially contribute to zero-redshift X-ray absorption lines in extragalactic sources.Comment: 11 pages, accepted for publication in Ap