Plaque-Type Psoriasis Treated with Calcipotriene Plus Betamethasone Dipropionate Aerosol Foam: A Prospective Study on Clinical and Dermoscopic Predictor Factors in Response Achievement and Retention

Introduction: Little information on possible local factors that can influence the achievement and retention of response of plaque-type psoriasis to calcipotriene plus betamethasone dipropionate aerosol foam is available. The aim of this study was to assess possible correlations between baseline clinical/dermoscopic features of psoriatic plaques and therapeutic response, and between residual dermoscopic findings in clinically improved/healed lesions and post-treatment relapse. Methods: For each target lesion, we calculated the local psoriasis severity index and assessed dermoscopic findings at baseline and at the end of a 4-week treatment, correlating the therapeutic outcome with the initial clinical and dermoscopic features. The lesions were also followed for a 4-week post-treatment period, and possible associations between relapse and (1) baseline clinical/dermoscopic features and (2) dermoscopic findings detected at the end of the treatment were assessed. Results: A total of 105 lesions from 35 patients were included in the analysis. After 4\ua0weeks of therapy, 13 lesions showed no/limited improvement, while partial and optimal response were observed in 51 and 41 plaques, respectively. Poor outcomes were correlated with both legs localization\ua0and degree of lesion infiltration at baseline. Similarly, presence of globular vessels at baseline dermoscopy was more commonly associated with no/limited response and lesions on the legs, particularly those showing resistance to treatment. A correlation was also found between dotted vessels on the baseline dermoscopic examination and good outcomes (partial/optimal response). After a 4-week post-treatment follow-up, 58.7% of the lesions achieving improvement at the end of the therapy showed relapse, with a correlation between recurrence and vessel persistence\ua0on dermoscopy at the end of the therapy. Conclusion: Clinical response of plaque-type psoriasis to calcipotriol/betamethasone dipropionate spray foam may be adversely affected by the degree of infiltration of lesions at baseline and by legs\ua0localization, and the presence of globular vessels at the baseline dermoscopic assessment is related to poor outcomes. A significant post-treatment relapse rate was observed, and persistence of vascular changes on dermoscopy seems to play a role in promoting disease recurrence

How can we improve antidepressant adherence in the management of depression? A targeted review and 10 clinical recommendations.

Adherence to antidepressants is crucial for optimal treatment outcomes when treating depressive disorders. However, poor adherence is common among patients prescribed antidepressants. This targeted review summarizes the main factors associated with poor adherence, interventions that promote antidepressant adherence, pharmacological aspects related to antidepressant adherence, and formulates 10 clinical recommendations to optimize antidepressant adherence. Patient-related factors associated with antidepressant non-adherence include younger age, psychiatric and medical comorbidities, cognitive impairment, and substance use disorders. Prescriber behavior-related factors include neglecting medical and family histories, selecting poorly tolerated antidepressants, or complex antidepressant regimens. Multi-disciplinary interventions targeting both patient and prescriber, aimed at improving antidepressant adherence, include psychoeducation and providing the patient with clear behavioral interventions to prevent/minimize poor adherence. Regarding antidepressant choice, agents with individually tailored tolerability profile should be chosen. Ten clinical recommendations include four points focusing on the patient (therapeutic alliance, adequate history taking, measurement of depressive symptoms, and adverse effects improved access to clinical care), three focusing on prescribing practice (psychoeducation, individually tailored antidepressant choice, simplified regimen), two focusing on mental health services (improved access to mental health care, incentivized adherence promotion and monitoring), and one relating to adherence measurement (adherence measurement with scales and/or therapeutic drug monitoring)

Type tecnological survey for a proposal building restauration

Questo lavoro è la prima sintesi di una ricerca internazionale finanziata dal MIUR all’interno del programma INTERLINK, sviluppata nella città di Elbasan in Albania, finalizzata alla comprensione degli elementi caratterizzanti il tipo edilizio presente all’interno della Kalà (cittadella fortificata). Tale ricerca ha avuto l’ambizione di fornire indicazioni e strumenti operativi per le successive fasi di pianificazione urbanistica e recupero edilizi

Sulla separazione di uranio da soluzioni acquose molto diluite

The recovery of uranium from dilute solutions and sea water is discussed from the scientific, technoogic and economic points of view

Bonding and fluxional behavior of N,N'-di-p-tolylformamidino and 1,3-di-p-tolyltriazenido complexes of palladium(II)and platinum(II)

The fluxionality of M(PPh3)2Cl(ArNXNAr) and trans-Pt(PPh3)2H(ArNNNAr) (M = Pd(II), Pt(II); Ar = p-MeC6H4; X = CH, N), is discussed on the basis of 1H NMR, x-ray, and ir studies. The stereochem. non-rigid process is proposed to occur via a pseudo-pentacoordinate intermediate having both N atoms facing the metal through 2 electron lone pairs. A different mechanism via a -bonding component in the M-(N ligand) bond is also discussed

A novel synthesis and X-ray structure of a new aryldiazene complex: trans-(phenylacetylide)bis(triphenylphosphine)(p-fluorophenyldiazene)platinum(II) tetrafluoroborate

The title compound [Pt(CCPh)(HNNC6H4F-p)(PPh3)2](BF4) has been synthesized from Pt(HCCPh)(PPh3)2 and p-FC6H4N2BF4, and a mechanism for its formation is proposed; X-ray diffraction studies show that the acetylide ligand is σ-bonded and that the PCCC system is essentially linear, while the diazene ligand has a trans configuration around the NN bond, and the hydrogen-bearing nitrogen atom is coordinated to the platinum. © 1975

Hydrogenation of aryldiazenido complexes. Synthesis and structure of trans-hydrido(acetonephenylhydrazone)bis(triphenylphosphine)platinum(II) tetrafluoroborate

Pt(BF4)(N:NAr)(PPh3)2 (Ar = C6H5, p-FC6H4) can be hydrogenated in a variety of solvents under mild conditions using no addnl. catalyst. In ethanol the hydrazine complex [PtH(H2NNHAr)(PPh3)2][BF4] is formed, while in the presence of acetone the corresponding hydrazone complex results. The ready availability of a coordination site on the Pt(N:NAr)(PPh3)2 unit must play a key role in the easy activation of mol. H which leads to these hydrazine derivs. The crystal structure of trans-[PtH(PhHNNC3H6)(PPh3)2][BF4]•C6H6 was detd. The coordination geometry about the Pt atom is square planar with trans phosphine groups. The hydrazone group is bound to the Pt atom through the sp2- hydridized N atom