Dissipative quantum mechanics and Kondo-like impurities on noncommutative two-tori

In a recent paper, by exploiting the notion of Morita equivalence for field theories on noncommutative tori and choosing rational values of the noncommutativity parameter $\theta$ (in appropriate units), a general one-to-one correspondence between the $m$-reduced conformal field theory (CFT) describing a quantum Hall fluid (QHF) at paired states fillings $\nu =\frac{m}{pm+2}$ and an Abelian noncommutative field theory (NCFT) has been established . That allowed us to add new evidence to the relationship between noncommutativity and quantum Hall fluids\cite% {ncmanybody}. On the other hand, the $m$-reduced CFT is equivalent to a system of two massless scalar bosons with a magnetic boundary interaction as introduced by Callan et al., at the so called ``magic''\ points. We are then able to describe, within such a framework, the dissipative quantum mechanics of a particle confined to a plane and subject to an external magnetic field normal to it. Here we develop such a point of view by focusing on the case $m=2$ which corresponds to a quantum Hall bilayer. The key role of a localized impurity which couples the two layers is emphasized and the effect of noncommutativity in terms of generalized magnetic translations (GMT) is fully exploited. As a result, general GMT operators are introduced, in the form of a tensor product, which act on the QHF and defect space respectively, and a comprehensive study of their rich structure is performed.Comment: 18 pages, 1 figure, accepted for publication in International Journal of Modern Physics

KMT2C modulates migration and invasion processes in osteosarcoma cell lines

In this study we investigated the role of KMT2C (a chromatin-modifying and remodelling protein) in osteosarcoma progression through cell migration and invasion assays in osteosarcoma primary and metastatic cell lines. Wound healing and transwell assays were used to detect changes of cell migration and matrigel assay was used to evaluate changes of cell invasion in primary and metastatic osteosarcoma cell lines after KMT2C siRNA transfection. We found that primary osteosarcoma cell lines showed the highest capacity of migration before mRNA KMT2C silencing and the highest capacity of invasion after mRNA KMT2C silencing; on the contrary, osteosarcoma metastatic cell line showed the highest capacity of migration after mRNA KMT2C silencing and the highest capacity of invasion before mRNA KMT2C silencing. Our study supports data in favour of selective enhancer changes, KMT2C-mediated, in metastatic osteosarcoma probably due to the different microenvironment between primary and metastatic sites

Total thyroidectomy associated to chemotherapy in primary squamous cell carcinoma of the thyroid

Primary squamous cell carcinoma of the thyroid (PSCCT) is a rare malignant disease with rapid fatal prognosis. The onset is generally characterized by sudden bilateral latero-cervical lymphadenopathy. The Authors report patient of 58-year-old who referred for evaluation of rapidly aggravating bilateral latero-cervical lymphadenopathy. The US highlighted the presence of a hypoechoic nodular lesion characterized by peri and intra-nodular vascularization. Multilayer CT showed diffused involvement of mediastinal and bilateral latero-cervical lymph nodes, with no evidence of primary pulmonary neoplasia or elsewhere. The patient underwent total thyroidectomy. The peri-isthmic tissue was removed due to the presence of a small roundish formation, that was due to lymph node metastasis at histological examination. Histological diagnosis: PSCCT. The immunohistochemical panel of the thyroid lesion was indispensable for the differential diagnosis between PSCCT, medullary carcinoma, anaplastic carcinoma, and thyroid metastasis of neoplasia with unknown primitiveness. The patient underwent chemotherapeutic treatment with Carboplatin and Paclitaxel with modest improvement of dysphagia symptoms and reduction of 10-15% of the target lesions. The clinical course was characterized by loco-regional progression of the disease with exitus in 10 months after diagnosis. Survival and quality of life after surgical therapy and chemotherapy were like that of patients undergoing only chemotherapy. Due to the extreme rarity of the neoplasia, 60 cases described in Literature, no exclusive guidelines are reported for PSCCT. More extensive case studies are needed to evaluate the effects of total thyroidectomy with intent R0/R1 on improving survival and quality of life of patients with PSCCT

CFT description of the Fully Frustrated XY model and phase diagram analysis

Following a suggestion given in Nucl. Phys. B 300 (1988)611,we show how the U(1)*Z_{2} symmetry of the fully frustrated XY (FFXY) model on a square lattice can be accounted for in the framework of the m-reduction procedure developed for a Quantum Hall system at "paired states" fillings nu =1 (cfr. Cristofano et al.,Mod. Phys. Lett. A 15 (2000)1679;Nucl. Phys. B 641 (2002)547). The resulting twisted conformal field theory (CFT) with central charge c=2 is shown to well describe the physical properties of the FFXY model. In particular the whole phase diagram is recovered by analyzing the flow from the Z_{2} degenerate vacuum of the c=2 CFT to the infrared fixed point unique vacuum of the c=3/2 CFT. The last theory is known to successfully describe the critical behavior of the system at the overlap temperature for the Ising and vortex-unbinding transitions.Comment: 18 pages, 1 figure, to appear in JSTA

Breast metastasis and lung large-cell neuroendocrine carcinoma: first clinical observation

The lung Large-cell neuroendocrine carcinoma (LCNEC) is a very rare aggressive neuroendocrine tumor with a high propensy to metastasize and very poor prognosis. We report an atypical presentation of lung large-cell neuroendocrine carcinoma was diagnosed from a metastatic nodule on the breast. Our patient is a 59 years-old woman that presented in March 2014 non productive cough. A CT scan showed multiple brain, lung, adrenal gland and liver secondary lesions; moreover, it revealed a breast right nodule near the chest measuring 1.8 cm. The breast nodule and a lung lesions were biopsied and their histology and molecular diagnosis were LCNEC of the lung. To our knowledge, this is the first documented case of breast metastasis from LCNEC of the lung. Furthermore, breast metastasis from extramammary malignancy is uncommon and its diagnosis is difficult but important for proper management and prediction of prognosis. Therefore, a careful clinical history with a thorough clinical examination is needed to make the correct diagnosis. Moreover, metastasis to the breast should be considered in any patient with a known primary malignant tumor history who presents with a breast lump. Anyhow, pathological examination should be performed to differentiate the primary breast cancer from metastatic tumor. Therefore, an accurate diagnosis of breast metastases may not only avoid unnecessary breast resection, more importantly it is crucial to determine an appropriate and systemic treatment

Infinite Symmetry in the Fractional Quantum Hall Effect

We have generalized recent results of Cappelli, Trugenberger and Zemba on the integer quantum Hall effect constructing explicitly a ${\cal W}_{1+\infty}$ for the fractional quantum Hall effect such that the negative modes annihilate the Laughlin wave functions. This generalization has a nice interpretation in Jain's composite fermion theory. Furthermore, for these models we have calculated the wave functions of the edge excitations viewing them as area preserving deformations of an incompressible quantum droplet, and have shown that the ${\cal W}_{1+\infty}$ is the underlying symmetry of the edge excitations in the fractional quantum Hall effect. Finally, we have applied this method to more general wave functions.Comment: 15pp. LaTeX, BONN-HE-93-2

Topological Order in Frustrated Josephson Junction Arrays

We show that electrically and magnetically frustrated Josephson junction arrays (JJAs) realize topological order with a non-trivial ground state degeneracy on manifolds with non-trivial topology. The low-energy theory has the same gauge dynamics of the unfrustrated JJAs but for different, "fractional" degrees of freedom, a principle reminescent of Jain's composite electrons in the fractional quantum Hall effect.Comment: 5 pages; to appear in EP

A late onset widespread skin rash in a previous Covid-19 infected patient. Viral or multidrug effect?

In the end of 2019, a series of pneumonia cases emerged in China, with clinical presentations greatly resembling viral pneumonia, caused by Covid-19 o SARS-CoV-2. Currently, several clinicians described an increasingly cases of coronavirus-positive patients reporting skin problems, either in early stage of infection or as late onset manifestation. Recently, Dr. Sebastiano Recalcati analyzed the cutaneous involvement in 148 COVID-19 patients hospitalized in the Lecco Hospital, Lombardy, Italy