Main data in patients included in the study.

<p>Main data in patients included in the study.</p

Distribution of the cohort by age groups.

<p>Distribution of the cohort by age groups.</p

Temporal distribution of cohort during the study period: Cases and anual incidence rate <i>(cases per 105 person-years</i>).

<p>Data of Minimum Basic Data Set 1998–2014.</p

Additional file 1 of Baseline NT-proBNP levels as a predictor of short-and long-term prognosis in COVID-19 patients: a prospective observational study

Supplementary Material

Serum cytokine and chemokine profiles in patients with malaria or with other diseases.

<p>Cytokines and chemokines were measured in serum of immigrants and travelers with malaria (dark grey boxes) and in serum of immigrants and travelers with other diseases (light grey boxes). Data are presented as boxplots that illustrate the medians and the 25^th and 75^th quartile. Whiskers represent the 10% and 90% percentiles and outliers are marked with circles. A Mann Whitney U test was performed to compare groups with malaria with groups with other diseases, and significant <i>P</i> values (<i>P</i><0.05) are shown.</p

Effect of loss of exposure on cytokine responses in immigrants compared to semi-immune individuals, all with a malaria acute episode.

<p>Cytokines and chemokines were measured in serum from immigrants and plasma from semi-immune adults by a multiplex suspension array kit and flow cytometry. The boxplots illustrate the medians and the 25^th and 75^th quartile and the whiskers represent the 10% and 90% percentiles. Outliers are marked with circles. A Mann Whitney U test was performed for each comparison, and significant <i>P</i> values (<i>P</i><0.05) are shown.</p

Effect of time of immigration on IL-2 and IFN-γ serum concentrations.

<p>Cytokine concentrations in serum from immigrants were measured by multiplex suspension array kit and flow cytometry and correlated with time of immigration. Only significant correlations are shown. Correlations were performed using Spearman’s test, n=52.</p

Epidemiological details.

<p>Epidemiological details.</p

Effect of loss of exposure on cytokine responses in immigrants compared to naïve individuals, all with a malaria episode.

<p>Serum cytokine and chemokine concentrations in immigrants and travelers at different time-points during and after a malaria episode: during an acute malaria episode (day 0, black boxes) and at convalescence (day 7 dark grey, day 28 light grey). Data are presented as boxplots that illustrate the medians and the 25^th and 75^th quartile and the whiskers represent the 10% and 90% percentiles. Outliers are marked with circles. A Mann Whitney U test was performed for each comparison, and significant <i>P</i> values (<i>P</i><0.05) are shown.</p

Clinical details.

<p>Clinical details.</p