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Solid-Phase Synthesis of Cyclic Depsipeptides Containing a Tyrosine Phenyl Ester Bond
The first solid-phase
strategy for the synthesis of cyclic depsipeptides
containing a phenyl ester linkage in their structure is described.
The key steps of the synthesis were the formation of the phenyl ester
bond and the on-resin head-to-side-chain cyclization. The amino acid
configuration significantly influenced the formation and the stability
of the cyclic depsipeptides. The presence of a l-Tyr<sup>1</sup> and a d-Tyr<sup>7</sup> led to the most stable sequences