Average values of the QT adaptation delays and measured in the three patient groups (third column), and , and in a simulated endocardial cell, and , with constant <i>β</i>-adrenergic stimulation (fourth column) and with the proposed time-varying <i>β</i>-adrenergic stimulation (fifth column).

Average values of the QT adaptation delays and measured in the three patient groups (third column), and , and in a simulated endocardial cell, and , with constant β-adrenergic stimulation (fourth column) and with the proposed time-varying β-adrenergic stimulation (fifth column).</p

Fitting of linear (red) and hyperbolic (black) regression models to a patient’s QT and RR data (“highCAD-4” in Table 1).

The data clusters correspond to the different windows Wi, i ∈ 1, 2, 3. The residual εrms took values of 4.27 and 1.75 ms for the linear and hyperbolic fittings, respectively.</p

Average values of the QT adaptation delays and (s) measured in the three CAD patient groups (third column), and , and in a simulated endocardial cell, and , with constant <i>β</i>-adrenergic stimulation (fourth column) and with the proposed time-varying <i>β</i>-adrenergic stimulation (fifth column).

Average values of the QT adaptation delays and (s) measured in the three CAD patient groups (third column), and , and in a simulated endocardial cell, and , with constant β-adrenergic stimulation (fourth column) and with the proposed time-varying β-adrenergic stimulation (fifth column).</p

Tested <i>β</i>-adrenergic stimulation patterns.

Simulated APD responses to HR changes for the four analyzed patterns of β-adrenergic stimulation. (PDF)</p

Table 1 -

Left column: codes used to identify the analyzed patients according to the risk group and the patient order number # within the group. Middle column: QT adaptation delay values measured in the exercise and recovery phases of the stress test for each patient, denoted by τe,p and τr,p with p indicating estimated from patients’ data. Right column: mean square error εrms for the linear and hyperbolic regression models calculated using the strategy.</p

Fig 4 -

Left panels: QT adaptation delay between dQT(n) and during exercise and recovery for a patient in the study. Middle panels: APD adaptation delay between dAPD(n) and during exercise and recovery in a simulated endocardial cell for constant β-adrenergic stimulation and the same HR as for the patient in the left. Right panels: APD adaptation delay between dAPD(n) and during exercise and recovery in a simulated endocardial cell for the proposed time-varying β-adrenergic stimulation. Top panels show results using the estimation strategy, while bottom panels use the estimation strategy. The red points correspond to ne, o, ne, e, nr, o and nr, e, calculated as described in section 2.6, which delimit the exercise and recovery ramps in or . The blue points were identified in dQT(n) or dAPD(n) as the nearest samples to the red points having QT or APD values within 2 ms of the corresponding red point value.</p

Frequency of mutations in normal karyotype AML samples.

*<p>One primary AML sample presented concomitant <i>FLT3-ITD</i> and <i>FLT3-TKD</i> mutations.</p