Entwicklung und Optimierung eines quasikontinuierlichen Immissions-Messverfahrens zur simultanen Bestimmung der sauren Luftinhaltsstoffe HCl, NO_2 und SO_2 mit einem Aktivsammler

With 14 figs., 7 tabs., 15 refs.SIGLEAvailable from TIB Hannover: RO 2590(89) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Entwicklung und Optimierung eines quasikontinuierlichen Immissions-Messverfahrens zur simultanen Bestimmung der sauren Luftinhaltsstoffe HCl, NO_2 und SO_2 mit einem Aktivsammler

Main objective of this study during the report time is found to be the testing of different absorption materials for the simultaneous determination of acid gaseous pollutants like HCl, NO_2 and SO_2. These materials - so-called active collectors - were examined in laboratory-scale experiments using gas mixtures with various concentrations of the pollutants which should be chemisorbed by the active collectors. After eluation of the active collector and ion chromatographical analysis of the solutions informations about the absorption/desorption rate are obtained. In most cases adsorption were tested on which amino-functional groups are deposited by chemical reaction. The amino-groups act as reactive sites for the chemisorption of the acid gases. It can be observed that all tested materials are suitable for the measurement of HCl and SO_2. Additionally some types of absorption materials are effective for the simultaneous absorption of HCl, SO_2 and NO_2. (orig.)SIGLEAvailable from TIB Hannover: RO 2590(112) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekLand Baden-Wuerttemberg, Stuttgart (Germany); Commission of the European Communities (CEC), Brussels (Belgium)DEGerman

Fucose-functionalized precision glycomacromolecules targeting human norovirus capsid protein

Norovirus infection is the major cause of non-bacterial gastroenteritis in humans and has been the subject of numerous studies investigating the virus’s biophysical properties and biochemical function with the aim of deriving novel and highly potent entry inhibitors to prevent infection. Recently, it has been shown that the protruding P domain dimer (P-dimer) of a GII.10 Norovirus strain exhibits two new binding sites for L-fucose in addition to the canonical binding sites. Thus these sites provide a novel target for the design of multivalent fucose ligands as entry inhibitors of norovirus infections. In this current study, a first generation of multivalent fucose-functionalized glycomacromolecules was synthesized and applied as model structures to investigate the potential targeting of fucose binding sites in human norovirus P-dimer. Following previously established solid phase polymer synthesis, eight precision glycomacromolecules varying in number and position of fucose ligands along an oligo(amidoamine) backbone were obtained and then used in a series of binding studies applying native MS, NMR and X-ray crystallography. We observed only one fucose per glycomacromolecule binding to one P-dimer resulting in similar binding affinities for all fucose-functionalized glycomacromolecules, which based on our current findings we attribute to the overall size of macromolecular ligands and possibly to steric hindrance