Non-demolition measurements of observables with general spectra

It has recently been established that, in a non-demolition measurement of an observable $\mathcal{N}$ with a finite point spectrum, the density matrix of the system approaches an eigenstate of $\mathcal{N}$, i.e., it "purifies" over the spectrum of $\mathcal{N}$. We extend this result to observables with general spectra. It is shown that the spectral density of the state of the system converges to a delta function exponentially fast, in an appropriate sense. Furthermore, for observables with absolutely continuous spectra, we show that the spectral density approaches a Gaussian distribution over the spectrum of $\mathcal{N}$. Our methods highlight the connection between the theory of non-demolition measurements and classical estimation theory.Comment: 22 page

Targeting hyperarousal: Mantram Repetition Program for PTSD in US veterans.

Background: Hyperarousal appears to play an important role in the development and maintenance of posttraumatic stress disorder (PTSD) symptoms, but current evidence-based treatments appear to address this symptom type less effectively than the other symptom clusters. The Mantram Repetition Program (MRP) is a meditation-based intervention that has previously been shown to improve symptoms of posttraumatic stress disorder (PTSD) and may be especially helpful for hyperarousal. If MRP is an effective tool for decreasing this often treatment-resistant symptom cluster, it may become an important clinical tool. Objective: The goal of this secondary analysis was to examine the effect of the MRP on hyperarousal and other PTSD symptom clusters and to examine hyperarousal as a mediator of treatment response. Method: Secondary analyses were conducted on data from a randomized controlled trial in which Veterans with PTSD (n = 173) were assigned to the MRP or a non-specific psychotherapy control and assessed pre-treatment, post-treatment and 8 weeks after treatment completion. The impact of the interventions on PTSD symptom clusters was examined, and time-lagged hierarchical linear modelling was applied to examine alternative mediation models. Results: All PTSD symptom clusters improved in both treatments. MRP led to greater reductions in hyperarousal at post-treatment (Hedge's g = 0.57) and follow-up (Hedge's g = 0.52), and in numbing at post-treatment (Hedge's g = 0.47). Hyperarousal mediated reductions in the composite of the other PTSD symptom clusters. Although the reverse model was significant as well, the effect was weaker in this direction. Conclusion: Interventions focused on the management of hyperarousal may play an important role in recovery from PTSD. The MRP appears efficacious in reducing hyperarousal, and thereby impacting other PTSD symptom clusters, as one pathway to facilitating recovery

Detection of X-ray emission from the host clusters of 3CR quasars

We report the detection of extended X-ray emission around several powerful 3CR quasars with redshifts out to 0.73. The ROSAT HRI images of the quasars have been corrected for spacecraft wobble and compared with an empirical point-spread function. All the quasars examined show excess emission at radii of 15 arcsec and more; the evidence being strong for the more distant objects and weak only for the two nearest ones, which are known from other wavelengths not to lie in strongly clustered environments. The spatial profiles of the extended component is consistent with thermal emission from the intracluster medium of moderately rich host clusters to the quasars. The total luminosities of the clusters are in the range 4x10^44 - 3x10^45 erg/s, assuming a temperature of 4keV. The inner regions of the intracluster medium are, in all cases, dense enough to be part of a cooling flow.Comment: 21 pages including 4 figures and 4 tables. To be published in MNRA

Discovery of 14 radio pulsars in a survey of the Magellanic Clouds

A systematic survey of the Large and Small Magellanic Clouds for radio pulsars using the Parkes radio telescope and the 20-cm multibeam receiver has resulted in the discovery of 14 pulsars and the redetection of five of the eight previously known spin-powered pulsars believed to lie in the Magellanic Clouds. Of the 14 new discoveries, 12 are believed to lie within Clouds, three in the Small Cloud and nine in the Large Cloud, bringing the total number of known spin-powered pulsars in the Clouds to 20. Averaged over all positions within the survey area, the survey had a limiting flux density of about 0.12 mJy. Observed dispersion measures suggest that the mean free electron density in the Magellanic Clouds is similar to that in the disk of our Galaxy. The observed radio luminosities have little or no dependence on pulsar period or characteristic age and the differential luminosity function is consistent with a power-law slope of -1 as is observed for Galactic pulsars.Comment: In press, Ap

Loss of very-long O-antigen chains optimizes capsule-mediated immune evasion by Salmonella enterica serovar Typhi.

UnlabelledExpression of capsular polysaccharides is a variable trait often associated with more-virulent forms of a bacterial species. For example, typhoid fever is caused by the capsulated Salmonella enterica serovar Typhi, while nontyphoidal Salmonella serovars associated with gastroenteritis are noncapsulated. Here we show that optimization of the immune evasive properties conferred by the virulence-associated (Vi) capsular polysaccharide involved an additional alteration to the cell envelope of S. Typhi, namely inactivation of the fepE gene, encoding the regulator of very-long O-antigen chains. Introduction of the capsule-encoding viaB locus into the nontyphoidal S. enterica serovar Typhimurium reduced complement deposition in vitro and intestinal inflammation in a mouse colitis model. However, both phenotypes were markedly enhanced when the viaB locus was introduced into an S. Typhimurium fepE mutant, which lacks very-long O-antigen chains. Collectively, these data suggest that during the evolution of the S. Typhi lineage, loss of very-long O-antigen chains by pseudogene formation was an adaptation to maximize the anti-inflammatory properties of the Vi capsular polysaccharide.ImportanceGenomic comparison illustrates that acquisition of virulence factors by horizontal gene transfer is an important contributor to the evolution of enteric pathogens. Acquisition of complex virulence traits commonly involves horizontal transfer of a large gene cluster, and integration of the gene cluster into the host genome results in the formation of a pathogenicity island. Acquisition of the virulence-associated (Vi) capsular polysaccharide encoded by SPI7 (Salmonella pathogenicity island 7) was accompanied in the human-adapted Salmonella enterica serovar Typhi by inactivation of the fepE gene, encoding the regulator of very-long O-antigen chains. We show that the resulting loss of very-long O-antigen chains was an important mechanism for maximizing immune evasion mediated by the Vi capsular polysaccharide. These data suggest that successful incorporation of a capsular polysaccharide requires changes in the cell envelope of the hosting pathogen

X-ray emission from the field of the hyperluminous IRAS galaxy IRASF15307+3252

We report on a 20-ks observation of the z = 0.93 hyperluminous galaxy IRAS F15307+3252 with the ROSAT HRI. No X-ray source is detected at the position of F15307+3252 at an upper limit of ∼4 × 10⁴³ erg s⁻¹. This is less than 2 × 10⁻⁴ of the bolometric luminosity of the object, and indicates either that the nucleus emits an unusually small fraction of its total power in X-rays, or that little of the nuclear X-ray flux is scattered into our line of sight by electrons. The lack of an X-ray detection around F15307+3252 also rules out it being at the centre of a cluster, such as is observed for IRAS P09104+4109. A weak, possibly extended, X-ray source is detected 13 arcsec south of the galaxy, spatially coincident with a clump of faint objects visible in a Keck K_s-band image of the field. This may be the core of a cluster near the line of sight to F15307+3252