S. Craig Watkins: One Thing We Must Do Now

Craig Watkins writes about the importance of ethical designs in technology during the COVID-19 era on April 7, 2020.Office of the VP for Researc

Underutilizing the ultimate technology during COVID—the human imagination

NYTPress includes a piece from the Good Systems team about the COVID-19 outbreak on April 10, 2020.Office of the VP for Researc

One Thing We Must Do Now

You are viewing a publication from UT Affiliates from the May 2020 Good Systems Network Digest.Office of the VP for Researc

The Power of Play: The Portrayal and Performance of Race in Video Games

Part of the Volume on the Ecology of Games: Connecting Youth, Games, and LearningThe chapter addresses the following question: in what ways do young people's interactions with video games influence how and what they learn about race? We begin by examining one of the most heavily marketed genres in the video games marketplace, what we call "urban/street" games. Specifically, we consider how these games, and the richly detailed and textured urban landscapes they present, establish powerful learning environments that help situate how young gamers understand, perform, and reproduce race and ethnicity. Next, we focus on the aesthetic and narrative properties of one of the most controversial yet successful video games franchises in America, Grand Theft Auto. More precisely, we consider how Grand Theft Auto teaches dominant attitudes and assumptions about race and racial Otherness through racialized pedagogical zones (RPZs). In the final section of the paper we expand the discussion of race and games to include concerns about access to and participation in digital media culture

Library I.T.: Information Technologists or Information Thought-leaders?

Library staff employed in information technology departments are often seen as support staff, only providing services when something breaks. But what more can library IT staff do to support the mission of their libraries? In this presentation we will explore why library IT staff should maximize their ability to work across various library departments to collaboratively design new library services rather than being relegated to support staff. We will also explore how library IT staff may challenge traditional bureaucratic organization structures to lead change efforts

Study of the Economic Desirability of Coating Pipe Internally to Reduce Pressure Losses

Industrial Engineering and Managemen

Differential cytokine gene expression profiles in the three pathological forms of sheep paratuberculosis

<p>Abstract</p> <p>Background</p> <p>Johne's disease is a chronic inflammatory disease of the gut caused by infection with <it>Mycobacterium avium </it>subspecies <it>paratuberculosis </it>(MAP). Symptoms include wasting, diarrhoea, loss of condition and eventual death. Three forms of Johne's disease have been described in sheep – paucibacillary, multibacillary and asymptomatic. The paucibacillary form is characterized by an inflammatory, Th1-type immune response. The multibacillary form of the disease, which disseminates the infection, is characterized by macrophage infiltration mediated by a Th2-type immune response, and asymptomatic animals have no clinical symptoms or pathology but are infected with MAP. What determines these three forms of the disease is unknown. To further understand these differences, we used real-time RT-PCR to compare the expression of thirteen cytokine and cytokine-related genes in ileal tissue from sheep with the three forms of the disease.</p> <p>Results</p> <p>Three pathological forms of sheep paratuberculosis were defined on the basis of histopathology, cytochemistry (Zeihl-Neelsen) and IS900 PCR. Paucibacillary lesions have largely T cell and eosinophil infiltration and are ZN negative; multibacillary lesions have macrophage infiltration and large numbers of acid-fast bacteria. The pauci- and multibacillary forms are linked to the differential expression of IFNγ and IL-10 respectively. In addition the increased levels of the proinflammatory cytokines (IL-1β and TNFα), IL-8, IL-18 and TRAF-1 in both diseased forms is indicative of persistent inflammatory lesions. No changes were seen in IL-1α in any sheep ileum tissues. Asymptomatic animals are IS900+ with normal histology but have significantly decreased levels of IL-18 and increased levels TNFα.</p> <p>Conclusion</p> <p>We have quantified the expression levels of thirteen cytokine and cytokine related genes in three forms of ovine paratuberculosis using real-time PCR analyses and confirm that sheep pauci- and multibacillary disease are linked to type 1 and type 2 T cell responses respectively. The expression patterns of other cytokines shows that both disease forms have an inflammatory aetiology but that the central role for IL-1α in bovine paratuberculosis is not seen in the sheep infection. Asymptomatic animals are infected and show no pathology but can be distinguished, in terms of cytokine expression pattern, from uninfected controls.</p