Organizational control & the Catholic Church: a case study

This paper presents an analysis of the problem of child-abusing priests in the Catholic Church using data from the USA, UK and Ireland. The apparent scale of this issue raises crucial theoretical as well as policy issues. This paper explores various organizational explanations, linking it to traditional methods of ‘confessional control’ of organizational members. This is a novel concept which brings the issue into a wider organizational lens. Confessional control creates a series of guilt-laden identities that serve to maintain hierarchical control as well as social inclusion. Thus the process of recycling priests was part of a long-persisting pattern applied to child abuse cases. The theoretical implications of this are explored. The data consists of a series of cases across the three countries, partly drawn from a data-base of 4,000 alleged cases

The Value of User Participation in E-Commerce Systems Development

The importance attached to user participation in contributing to the success of an information system has been a long held theoretical belief. Systems development techniques have been promoted that involve user participation such as prototyping, rapid application development and joint application design. Interestingly, the research literature on the topic has not been conclusive about the real value of user partic ipation, although the perception of value has still existed. The importance of user participation could be seen as a myth in information systems

Success? The impact of involving customers in E-commerce development

In e-commerce, customers have become Information System users. In this environment of non-mandatory usage, remote, untrained users need to quickly feel comfortable and satisfied with a site encounter. Throughout the literature for four decades, a commonly cited factor pertaining to system success has been user participation in the systems development process. Among other things this is likely to lead to increased user satisfaction and the perceived usefulness of the application. This study uses findings from thirty cases of recently completed e-commerce sites in which project leaders accounts of customer participation in e-commerce development activities are analysed, along with their perceptions of success, as well as those of customers of the sites. The business need for a rewarding customer experience on an ecommerce site would suggest customer input would substantially infiuence the site design. The study finds that although participation by customers in developmental activities is occurring, it is having little infiuence on the design and success of the site

Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C.elegans Embryos

SummaryDuring cell division, chromatin alternates between a condensed state to facilitate chromosome segregation and a decondensed form when DNA replicates. In most tissues, S phase and mitosis are separated by defined G1 and G2 gap phases, but early embryogenesis involves rapid oscillations between replication and mitosis. Using Caenorhabditis elegans embryos as a model system, we show that chromosome condensation and condensin II concentration on chromosomal axes require replicated DNA. In addition, we found that, during late telophase, replication initiates on condensed chromosomes and promotes the rapid decondensation of the chromatin. Upon replication initiation, the CDC-45-MCM-GINS (CMG) DNA helicase drives the release of condensin I complexes from chromatin and the activation or displacement of inactive MCM-2–7 complexes, which together with the nucleoporin MEL-28/ELYS tethers condensed chromatin to the nuclear envelope, thereby promoting chromatin decondensation. Our results show how, in an early embryo, the chromosome-condensation cycle is functionally linked with DNA replication

User Involvement in E-Commerce Systems Development

It has been said that there is only one opportunity to make a first impression. In the competitive world of ecommerce, attracting customers to a Web site is expensive; keeping them is a business imperative. The utility of the Web site from the user perspective is critical to success, and evidence suggests that an unrewarding initial experience will thwart further interaction with the site. Throughout the literature since the 1960’s, a commonly cited factor pertaining to system success has been user involvement in the systems development process. Among other things this is likely to lead to increased user satisfaction and the perceived usefulness of the application. The study examines e-commerce application developments at a number of organisations, and reports on the role of users in the development process. Despite the business need for remote, untrained users to quickly feel comfortable and satisfied in an e-commerce site encounter, it appears that organisations are making very little effort to engage users in any e-commerce site developmental activities

Survival outcome and EMT suppression mediated by a lectin domain interaction of Endo180 and CD147

Epithelial cell-cell contacts maintain normal glandular tissue homeostasis, and their breakage can trigger epithelial-to-mesenchymal transition (EMT), a fundamental step in the development of metastatic cancer. Despite the ability of C-type lectin domains (CTLD) to modulate cell-cell adhesion, it is not known if they modulate epithelial adhesion in EMT and tumor progression. Here, the multi-CTLD mannose receptor, Endo180 (MRC2/uPARAP), was shown using the Kaplan-Meier analysis to be predictive of survival outcome in men with early prostate cancer. A proteomic screen of novel interaction partners with the fourth CTLD (CTLD4) in Endo180 revealed that its complex with CD147 is indispensable for the stability of three-dimensional acini formed by nontransformed prostate epithelial cells (PEC). Mechanistic study using knockdown of Endo180 or CD147, and treatment with an Endo180 mAb targeting CTLD4 (clone 39.10), or a dominant-negative GST-CTLD4 chimeric protein, induced scattering of PECs associated with internalization of Endo180 into endosomes, loss of E-cadherin (CDH1/ECAD), and unzipping of cell-cell junctions. These findings are the first to demonstrate that a CTLD acts as a suppressor and regulatory switch for EMT; thus, positing that stabilization of Endo180-CD147 complex is a viable therapeutic strategy to improve rates of prostate cancer survival

Internal cantholysis for full thickness eyelid defects

AbstractEyelid reconstruction requires an understanding of normal eyelid anatomy and function. A thorough understanding of the basic anatomy, contour, and mobility of the eyelids is essential in restoring the tissue to its presurgical level. There are many different surgical options to assist in the repair of full thickness eyelid defects involving the margin. Direct wound closure depends on eyelid laxity and is often possible with smaller defects. Moderate to larger sized defects are often under undue wound tension if direct closure is attempted. We have developed a new technique for closure of eyelid defects using a transconjunctival cantholysis to release the lateral canthal tendon cruces, thereby avoiding the external incision while still allowing for eyelid mobility. Using this technique for defects 15mm in horizontal eyelid margin length or greater, we have found positive results. Direct closure of eyelid defects represents the most straightforward technique to repair any full-thickness eyelid defect and provides maximal functional and cosmetic results. Internal cantholysis represents an excellent option for repairing smaller and even larger full thickness eyelid defects. Eyelid mobility increases by 4–10mm, sometimes more, and allows for closure of defects larger than even 20mm