Additional file 1: of Risk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort

Supplementary Data and Methods. (DOCX 38 kb

Additional file 1: Table S1. of Childhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPDGene study

Chest CT Parameters for Subjects With and Without History of Childhood Pneumonia. Table S2. Effect of Childhood Pneumonia with Childhood Asthmatics Removed. Table S3. Effect of Childhood Pneumonia in Childhood Asthmatics Only. Table S4. Recall Assessment in Subjects Who Did Not Report Known COPD or Emphysema Diagnosis. Figure S1. Classification of subjects in cohort based on childhood pneumonia status. Figure S2. Distribution of age of first pneumonia in entire cohort (a) in subjects with a history of childhood pneumonia (b) and in subjects without a history of childhood pneumonia (c). Includes all subjects who reported an age of first pneumonia. (PDF 943 kb

Additional file 16: of RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking

IRB approval and complete list of acknowledgements. (DOCX 20 kb

Additional file 13: Figure S9. of RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking

Exon-level expression of MAN1A2. The top plot shows mean normalized counts by smoking status on the log scale for each analyzed exon. One exon that showed significant differential usage (ENSE00001635177). The bottom table maps tested exons to known transcripts (1 = exon present in that transcript, 0 = exon not present in that transcript). (PNG 51 kb

Additional file 6: Table S3. of RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking

Significant gene ontology terms over-represented in genes differentially expressed between current and former smokers. P-values are Bonferroni corrected for multiple comparisons. (XLSX 16 kb

Additional file 10: Figure S6. of RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking

Exon-level expression of SASH1. The top plot shows mean normalized counts by smoking status on the log scale for each analyzed exon. One exon showed significant differential usage (ENSE00001444573). The bottom table maps tested exons to known transcripts (1 = exon present in that transcript, 0 = exon not present in that transcript). (PNG 64 kb

Additional file 9: Figure S5. of RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking

Exon-level expression of EPS15. The top plot shows mean normalized counts by smoking status on the log scale for each analyzed exon. One exon showed significant differential usage (ENSE00001810132). The bottom table maps tested exons to known transcripts (1 = exon present in that transcript, 0 = exon not present in that transcript). (PNG 92 kb

Additional file 8: Figure S4. of RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking

Quantile-quantile (QQ) plot for differential exon usage between current and former smokers using the topSplice exon-based T-statistic. (PNG 16 kb

Additional file 11: Figure S7. of RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking

Exon-level expression of AREL1. The top plot shows mean normalized counts by smoking status on the log scale for each analyzed exon. One exon showed significant differential usage (ENSE00001400828). The bottom table maps tested exons to known transcripts (1 = exon present in that transcript, 0 = exon not present in that transcript). (PNG 102 kb

Additional file 12: Figure S8. of RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking

Exon-level expression of last 11 exons of UTRN. The top plot shows mean normalized counts on the log scale for each exon passing filtering by smoking status. There was one exon that showed significant differential usage between current and former smokers (ENSE00001444981). The bottom table maps tested exons to known transcripts (1 = exon present in that transcript, 0 = exon not present in that transcript). (PNG 141 kb