15,295 research outputs found
Combustor liner construction
A combustor liner is fabricated from a plurality of individual segments each containing counter/parallel Finwall material and are arranged circumferentially and axially to define the combustion zone. Each segment is supported by a hook and ring construction to an opened lattice frame with sufficient tolerance between the hook and ring to permit thermal expansion with a minimum of induced stresses
Chipping away at gamma-H2AX foci
The mammalian histone H2AX protein functions as a dosage-dependent genomic caretaker and tumor suppressor. Phosphorylation of H2AX to form gamma-H2AX in chromatin around DNA double strand breaks (DSBs) is an early event following induction of these hazardous lesions. For a decade, mechanisms that regulate H2AX phosphorylation have been investigated mainly through two-dimensional immunofluorescence (IF). We recently used chromatin immunoprecipitation (ChIP) to measure gamma-H2AX densities along chromosomal DNA strands broken in G(1) phase mouse lymphocytes. Our experiments revealed that (1) gamma-H2AX densities in nucleosomes form at high levels near DSBs and at diminishing levels farther and farther away from DNA ends, and (2) ATM regulates H2AX phosphorylation through both MDC1-dependent and MDC1-independent means. Neither of these mechanisms were discovered by previous if studies due to the inherent limitations of light microscopy. Here, we compare data obtained from parallel gamma-H2AX ChIP and three-dimensional IF analyses and discuss the impact of our findings upon molecular mechanisms that regulate H2AX phosphorylation in chromatin around DNA breakage sites
Effect of time delay on feedback control of a flashing ratchet
It was recently shown that the use of feedback control can improve the
performance of a flashing ratchet. We investigate the effect of a time delay in
the implementation of feedback control in a closed-loop collective flashing
ratchet, using Langevin dynamics simulations. Surprisingly, for a large
ensemble, a well-chosen delay time improves the ratchet performance by allowing
the system to synchronize into a quasi-periodic stable mode of oscillation that
reproduces the optimal average velocity for a periodically flashing ratchet.
For a small ensemble, on the other hand, finite delay times significantly
reduce the benefit of feedback control for the time-averaged velocity, because
the relevance of information decays on a time scale set by the diffusion time
of the particles. Based on these results, we establish that experimental use of
feedback control is realistic.Comment: 6 pages, 6 figures, to appear in Europhysics Letter
The Dynamics of the One-Dimensional Delta-Function Bose Gas
We give a method to solve the time-dependent Schroedinger equation for a
system of one-dimensional bosons interacting via a repulsive delta function
potential. The method uses the ideas of Bethe Ansatz but does not use the
spectral theory of the associated Hamiltonian
Feedback-controlled transport in an interacting colloidal system
Based on dynamical density functional theory (DDFT) we consider a
non-equilibrium system of interacting colloidal particles driven by a constant
tilting force through a periodic, symmetric "washboard" potential. We
demonstrate that, despite of pronounced spatio-temporal correlations, the
particle current can be reversed by adding suitable feedback control terms to
the DDFT equation of motion. We explore two distinct control protocols with
time delay, focussing on either the particle positions or the density profile.
Our study shows that the DDFT is an appropriate framework to implement
time-delayed feedback control strategies widely used in other fields of
nonlinear physicsComment: 6 pages, 5 figure
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