5,605 research outputs found
Designing economic evaluations to facilitate optimal decisions: The need to avoid bias
Editorial Lette
Implications for Adoption and Implementation of Effective Sexual Health Education Programs
Research on school-based sexual health education programs is at a critical juncture. With the growing number of evidenced-based programs, more focus is needed on how to help schools adopt and implement these programs. The article in this issue titled “Sexual Health Education from the Perspectives of School Staff: Implications for Adoption and Implementation of Effective Programs in Middle School” provides data on individual cognitive factors that may influence adoption and implementation. This commentary explores another framework, Concerns Based Adoption Model, as a tool for examining and supporting change associated with adoption and implementation of sexual health education programs
No Boat, No Bridge
In a world that devours one technological advance after another, the simple human questions persist. They endure despite the increased speed of the personal computer or the decreased size of the cellular phone. In a time ruled by measurements they remain elusive and undefined. The longing for love, the crisis of past versus present, the nagging hunger for meaning in the face of constant change--these questions manage to be both small and huge, both slow and fast, all at once. They are the inheritance of every generation; they are written on the very lining of our hearts. These stories are, then, simply a short list of questions. Whether it be a story like Bones, 11 where love and time intersect, or one like There is A., 11 where moral strength is at issue, each asks a question. Each attempts by a different angle to flush some answers from the brush. What does it mean to love? When does hope become foolishness? When lost, is it always better to stay put? These are some of the concerns taken up in this collection. In the end, the answers remain just out of reach, having only just rounded the corner at our arrival. The reader is left to either the tremulous bravado of the boy in the second story, who asks, What do I care about wolves in the night anyway? or the paltry rebellion of the man in Making for the Phoenix who is reduced finally to throwing rocks at the windows in his office building
Collecting Data from Children Ages 9-13
Provides a summary of literature on common methods used to collect data, such as diaries, interviews, observational methods, and surveys. Analyzes age group-specific considerations, advantages, and drawbacks, with tips for improving data quality
Method for Alleviating Side Effects of Retinoic Acid Therapy and/or Improving Efficacy without Interfering with Efficacy
The invention relates to the use of nicotinic acid alkyl esters, especially myristyl nicotinate, to inhibit side effects associated with retinoic acid therapy. Also a part of the invention is a method for improving skin cell differentiation by administering the nicotinic acid alkyl ester in an amount sufficient to increase expression of caspase 14 and filaggrin. Deficiencies in expression of these molecules can be treated in this way as well
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Cost-effectiveness of integrated disease management for high risk, exacerbation prone, patients with chronic obstructive pulmonary disease in a primary care setting
Availability of data and materials: The datasets generated and/or analysed during the current study are not publicly available due to the requirement to keep individual patient health information confdential but are available from Dr. Licskai on reasonable request.Copyright © The Author(s) 2022. Background: We evaluate the cost-effectiveness of the ‘Best Care’ integrated disease management (IDM) program for high risk, exacerbation prone, patients with chronic obstructive pulmonary disease (COPD) compared to usual care (UC) within a primary care setting from the perspective of a publicly funded health system (i.e., Ontario, Canada). Methods: We conducted a model-based, cost-utility analysis using a Markov model with expected values of costs and outcomes derived from a Monte-Carlo Simulation with 5000 replications. The target population included patients started in GOLD II with a starting age of 68 years in the trial-based analysis. Key input parameters were based on a randomized control trial of 143 patients (i.e., UC (n = 73) versus IDM program (n = 70)). Results were shown as incremental cost per quality-adjusted life year (QALY) gained. Results: The IDM program for high risk, exacerbation prone, patients is dominant in comparison with the UC group. After one year, the IDM program demonstrated cost savings and improved QALYs (i.e., UC was dominated by IDM) with a positive net-benefit of 5175, 50,000 (CAN) per QALY. Conclusions: This study demonstrates that the IDM intervention for patients with COPD in a primary care setting is cost-effective in comparison to the standard of care. By demonstrating the cost-effectiveness of IDM, we confirm that investment in the delivery of evidence based best practices in primary care delivers better patient outcomes at a lower cost than UC. Highlights
I. Interventions that can reduce the frequency and severity of exacerbations in patients who sufer from COPD
have the potential to reduce the fnancial burden of COPD on the health system;
II. Tis is the frst study that demonstrates the cost-efectiveness of integrated disease management for patients
who sufer from COPD within a primary care environment; II. Tis study makes the case for embedding Certifed Respiratory Educators (CREs) within the primary care
environment to improve the quality of life of patients who sufer from COPD, as well as alleviating unneces sary health services utilization and decreasing the overall fnancial burden of the disease on the health system.Asthma Research Group Windsor Essex County Inc. doctoral stipend
Method for Treating Hair Growth Disorders, Such as Female Pattern Alopecia, and Compositions Useful Therefore
The invention relates to formulations useful in treating hair disorders, improving the health of hair, increasing hair growth, and in increasing the niacin content of hair follicles. Nicotinic acid alkyl esters having a straight chain alkyl group of from 1 to 22 methylene units, preferably from 6 to 16 methylene units, and most preferably from 8 to 14 methyl units, may be used, alone or in combinations for treating these conditions
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