Star Formation History since z = 1.5 as Inferred from Rest-Frame Ultaviolet Luminosity Density Evolution

We investigate the evolution of the universal rest-frame ultraviolet luminosity density from z = 1.5 to the present. We analyze an extensive sample of multicolor data (U', B, V = 24.5) plus spectroscopic redshifts from the Hawaii Survey Fields and the Hubble Deep Field. Our multicolor data allow us to select our sample in the rest-frame ultraviolet (2500 angstrom) over the entire redshift range to z = 1.5. We conclude that the evolution in the luminosity density is a function of the form (1+z)^{1.7\pm1.0} for a flat lambda cosmology and (1+z)^{2.4\pm1.0} for an Einstein-de Sitter cosmology.Comment: 12 pages, 7 figs, 5 tables, submitted to A

Visual control of action in step descent

Visual guidance of forwards, sideways, and upwards stepping has been investigated, but there is little knowledge about the visuomotor processes underlying stepping down actions. In this study we investigated the visual control of a single vertical step. We measured which aspects of the stepping down movement scaled with visual information about step height, and how this visual control varied with binocular versus monocular vision. Subjects stepped down a single step of variable and unpredictable height. Several kinematic measures were extracted including a new measure, “kneedrop”. This describes a transition in the movement of the lower leg, which occurs at a point proportional to step height. In a within-subjects design, measurements were made with either full vision, monocular vision, or no vision. Subjects scaled kneedrop relative to step height with vision, but this scaling was significantly impaired in monocular and no vision conditions. The study establishes a kinematic marker of visually controlled scaling in single-step locomotion which will allow further study of the visuomotor control processes involved in stepping dow

Visually guided step descent in children with Williams Syndrome

Individuals with Williams syndrome (WS) have impairments in visuospatial tasks and in manual visuomotor control, consistent with parietal and cerebellar abnormalities. Here we examined whether individuals with WS also have difficulties in visually controlling whole-body movements. We investigated visual control of stepping down at a change of level in children with WS (5–16-year-olds), who descended a single step while their movement was kinematically recorded. On each trial step height was set unpredictably, so that visual information was necessary to perceive the step depth and position the legs appropriately before landing. Kinematic measures established that children with WS did not use visual information to slow the leg at an appropriate point during the step. This pattern contrasts with that observed in typically developing 3- and 4-year-old children, implying severe impairment in whole-body visuomotor control in WS. For children with WS, performance was not significantly predicted by low-level visual or balance problems, but improved significantly with verbal age. The results suggest some plasticity and development in WS whole-body control. These data clearly show that visuospatial and visuomotor deficits in WS extend to the locomotor domain. Taken together with evidence for parietal and cerebellar abnormalities in WS, these results also provide new evidence for the role of these circuits in the visual control of whole-body movement

Faint M-dwarfs and the structure of the Galactic disk

We use broadband photometry and low-resolution spectra of a complete sample of late-K and M dwarfs brighter than I=22 in three fields at high galactic latitude to study issues relating to galactic structure and large scale abundance gradients in the Galaxy. The observed starcounts in each field are a good match to the predictions of models based on deep starcount data in other intermediate-latitude fields, and these models identify the late-type stars as members of the Galactic disk. Abundances for these late type stars are estimated via narrowband indices that measure the strength of the TiO and CaH bands in their spectra. Our results show that the average abundance in the Galactic disk remains close to solar even at heights of more than 2 kpc above the Plane.Comment: to appear in PASP; 17 pages, including 7 embedded, postscript figures and 1 embedded table; uses AAS LaTeX style files (not included); also available at http://astro.caltech.edu/~map/map.bibliography.htm

Resolving the Submillimeter Background: the 850-micron Galaxy Counts

Recent deep blank field submillimeter surveys have revealed a population of luminous high redshift galaxies that emit most of their energy in the submillimeter. The results suggest that much of the star formation at high redshift may be hidden to optical observations. In this paper we present wide-area 850-micron SCUBA data on the Hawaii Survey Fields SSA13, SSA17, and SSA22. Combining these new data with our previous deep field data, we establish the 850-micron galaxy counts from 2 mJy to 10 mJy with a >3-sigma detection limit. The area coverage is 104 square arcmin to 8 mJy and 7.7 square arcmin to 2.3 mJy. The differential 850-micron counts are well described by the function n(S)=N_0/(a+S^3.2), where S is the flux in mJy, N_0=3.0 x 10^4 per square degree per mJy, and a=0.4-1.0 is chosen to match the 850-micron extragalactic background light. Between 20 to 30 per cent of the 850-micron background resides in sources brighter than 2 mJy. Using an empirical fit to our >2 mJy data constrained by the EBL at lower fluxes, we argue that the bulk of the 850-micron extragalactic background light resides in sources with fluxes near 1 mJy. The submillimeter sources are plausible progenitors of the present-day spheroidal population.Comment: 5 pages, accepted by The Astrophysical Journal Letter

Evaluation of Overall Survival (OS) and Event-Free Survival (EFS) of paediatric sarcoma patients at a single institution

Aims: To evaluate OS and EFS of paediatric sarcoma patients with an interest in comparing metastatic cases with non-metastatic cases, and compiling statistics on treatment methods. Methods: Information was obtained from patient notes in the Schiehallion ward. These contained information about diagnosis, treatment, prognostic indicators, and outcomes for each patient. Results: 56 patients, 2001-2008. Osteosarcoma: 11 patients, 7♂, 4♀; age range: 4-16; = 10; OS = 64%, EFS = 55%; Primary site of disease: Femur (47%), Tibia (41%), Humerus (5.5%), Scapula (5.5%), Other (1%); Metastatic Rate = 27% (OS = 0%). Ewing’s sarcoma: 24 patients, 10♂, 14♀; age range: 1-16, = 12; OS = 71%, EFS = 58%; Primary site of disease: Pelvis (29%), Femur (22%), Paraspinal (16%), Chest Wall (10%), Tibia (10%), Other (13%); Metastatic Rate = 21% (OS = 40%; EFS = 40%); Alveolar rhabdomyosarcoma: 10 patients; OS= 80%, EFS = 60%; Metastatic Rate = 20% (OS = 100%; EFS = 100%). Embryonal rhabdomyosarcoma: 11 patients; OS = 73%, EFS = 73%; Metastatic Rate = 0%. Conclusions: Our results reflect access to an experienced and innovative paediatric sarcoma service with close links to a national Sarcoma MDT. The data falls in line with other studies in terms of age of onset, location of primary tumour, metastatic rate, site of metastases, and prognosis for all cancer types. Limb salvage surgery is greatly favoured over amputation for both osteosarcoma and Ewing’s sarcoma. Females have a more favourable prognosis in osteosarcoma and a slightly poorer prognosis in Ewing’s sarcoma. Yorkhill’s overall survival rates are currently better than the UK-wide statistic for three of the four tumours examined.</p

Proactive modulation of long-interval intracortical inhibition during response inhibition

Daily activities often require sudden cancellation of preplanned movement, termed response inhibition. When only a subcomponent of a whole response must be suppressed (required here on Partial trials), the ensuing component is markedly delayed. The neural mechanisms underlying partial response inhibition remain unclear. We hypothesized that Partial trials would be associated with nonselective corticomotor suppression and that GABA(B) receptor-mediated inhibition within primary motor cortex might be responsible for the nonselective corticomotor suppression contributing to Partial trial response delays. Sixteen right-handed participants performed a bimanual anticipatory response inhibition task while single- and paired-pulse transcranial magnetic stimulation was delivered to elicit motor evoked potentials in the left first dorsal interosseous muscle. Lift times, amplitude of motor evoked potentials, and long-interval intracortical inhibition were examined across the different trial types (Go, Stop-Left, Stop-Right, Stop-Both). Go trials produced a tight distribution of lift times around the target, whereas those during Partial trials (Stop-Left and Stop-Right) were substantially delayed. The modulation of motor evoked potential amplitude during Stop-Right trials reflected anticipation, suppression, and subsequent reinitiation of movement. Importantly, suppression was present across all Stop trial types, indicative of a “default” nonselective inhibitory process. Compared with blocks containing only Go trials, inhibition increased when Stop trials were introduced but did not differ between trial types. The amount of inhibition was positively correlated with lift times during Stop-Right trials. Tonic levels of inhibition appear to be proactively modulated by task context and influence the speed at which unimanual responses occur after a nonselective “brake” is applied

Cost-effectiveness of eplerenone in patients with systolic heart failure and mild symptoms

Aim In the Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF), aldosterone blockade with eplerenone decreased mortality and hospitalisation in patients with mild symptoms (New York Heart Association class II) and chronic systolic heart failure (HF). The present study evaluated the cost-effectiveness of eplerenone in the treatment of these patients in the UK and Spain.&lt;p&gt;&lt;/p&gt; Methods and results Results from the EMPHASIS-HF trial were used to develop a discrete-event simulation model estimating lifetime direct costs and effects (life years and quality-adjusted life years (QALYs) gained) of the addition of eplerenone to standard care among patients with chronic systolic HF and mild symptoms. Eplerenone plus standard care compared with standard care alone increased lifetime direct costs per patient by £4284 for the UK and €7358 for Spain, with additional quality-adjusted life expectancy of 1.22 QALYs for the UK and 1.33 QALYs for Spain. Mean lifetime costs were £3520 per QALY in the UK and €5532 per QALY in Spain. Probabilistic sensitivity analysis suggested a 100% likelihood of eplerenone being regarded as cost-effective at a willingness-to-pay threshold of £20 000 per QALY (UK) or €30 000 per QALY (Spain).&lt;p&gt;&lt;/p&gt; Conclusions By currently accepted standards of value for money, the addition of eplerenone to optimal medical therapy for patients with chronic systolic HF and mild symptoms is likely to be cost-effective.&lt;p&gt;&lt;/p&gt

A Submillimeter and Radio Survey of Gamma-Ray Burst Host Galaxies: A Glimpse into the Future of Star Formation Studies

We present the first comprehensive search for submillimeter and radio emission from the host galaxies of twenty well-localized gamma-ray bursts (GRBs). With the exception of a single source, all observations were undertaken months to years after the GRB explosions to ensure negligible contamination from the afterglows. We detect the host galaxy of GRB 000418 in both the sub-mm and radio, and the host galaxy of GRB 000210 only in the sub-mm. These observations, in conjunction with the previous detections of the host galaxies of GRB 980703 and GRB 010222, indicate that about 20% of GRB host galaxies are ultra-luminous and have star formation rates of about 500 M_sun/yr. As an ensemble, the non-detected hosts have a star formation rate of about 100 M_sun/yr (5-sigma) based on their radio emission. The detected and ensemble star formation rates exceed the optical values by an order of magnitude, indicating significant dust obscuration. In the same vein, the ratio of bolometric dust luminosity to UV luminosity for the hosts detected in the sub-mm and radio ranges from 20-800, and follows the known trend of increasing obscuration with increasing bolometric luminosity. We also show that, both as a sample and individually, the GRB host galaxies have bluer R-K colors as compared with galaxies selected in the sub-mm in the same redshift range. This possibly indicates that the stellar populations in the GRB hosts are on average younger, supporting the massive stellar progenitor scenario for GRBs, but it is also possible that GRB hosts are on average less dusty.Comment: Submitted to ApJ; 36 pages, 3 tables, 7 figures; updated reference