Actions of Calcium on Smooth Muscle a

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72185/1/j.1749-6632.1988.tb33358.x.pd

Effects of immediate post-game recovery procedures on muscle soreness, power and flexiblity levels over the next 48 hours

This study investigated whether or not immediate post-game recovery procedures could enhance the rate of recovery in Australian football players in the first 48 hr after a game. Control, stretch, pool walking and hot/cold recoveries were trialled. Typical next day recovery training (25 min of pool exercise) was also performed after each game. Muscle soreness ratings and measures of flexibility (sit and reach) and power (6-s cycling sprint and vertical jump) were obtained 45 hr pre-game (Thursdays) (baseline), 15 hr post-game (Sundays, prior to "next day" recovery) and 48 hr post-game (Mondays). Performance ratios (Sunday and Monday scores divided respectively by the Thursday score) were used as the primary index of recovery. Muscle soreness was significantly greater (p control, p control, p0.3). No differences were found between the three experimental recoveries. On Monday no significant differences were recorded in performance between the recoveries and the effect sizes were of lower magnitude. In conclusion, recovery of muscle soreness, flexibility and power at 48 hr post-game was not significantly enhanced by performing an immediate post-game recovery beyond that achieved by performing only next day recovery training

Decoupling of normal CD40/interleukin-4 immunoglobulin heavy chain switch signal leads to genomic instability in SGH-MM5 and RPMI 8226 multiple myeloma cell lines

The processes mediating genomic instability and clonal evolution are obscure in multiple myeloma (MM). Acquisition of new chromosomal translocations into the switch region of the immunoglobulin heavy chain (IgH) gene (chromosome 14q32) in MM, often heralds transformation to more aggressive disease. Since the combined effects of CD40 plus interleukin-4 (IL-4) mediate IgH isotype class switch recombination (CSR), and this process involves DNA double strand break repair (DSBR), we hypothesized that CD40 and/or IL-4 activation of MM cells could induce abnormal DNA DSBR and lead to genomic instability and clonal evolution. In this study, we show that MM cell lines that are optimally triggered via CD40 and/or IL-4 demonstrate abnormal decoupling of IL-4 signal transduction from CD40. Specifically, CD40 alone was sufficient to trigger maximal growth of tumor cells. We further demonstrate that CD40 triggering induced both DNA DSBs as well as newly acquired karyotypic abnormalities in MM cell lines. Importantly, these observations were accompanied by induction of activation induced cytidine deaminase expression, but not gross apoptosis. These data support the role of abnormal CD40 signal transduction in mediating genomic instability, suggesting a role for the CD40 pathway and intermediates in myelomagenesis and clonal evolution in vivo

Letting go without a fight : decolonization, democracy and war, 1900-94

Does the type of regime really make no difference to the likelihood of violent conflict over basic issues of stateness such as separatism and decolonization? Can democratic peace theory be successfully applied when dealing with the national identity or stateness question? This article extends the application of the democratic peace to the process of decolonization. It examines conflict between imperial states and their colonies during the process of decolonization and investigates the question of whether democracy affects the likelihood of conflict. The central finding is that, contrary to the implications of some prominent theories of state formation and democracy, democratic imperial states are significantly less likely to go to war with their colonial possessions in the process of achieving independence. Further, the authors find only a monadic, not dyadic, democratic peace effect. The regime type of the colony does not have a significant effect on the likelihood of war. It is the nature of the regime of imperial states, rather than that of colonies, that is a significant factor. In addition, the predominant source of this effect appears to be the institutional constraints placed on executive action within democracies, rather than the influence of mass politics or the effects of political competition. Regarding power-related factors, power parity between sovereign and colony makes conflict more likely (a colonial power-transition effect), but imperial decline actually makes war with colonies less likely. Sensitivity analysis reveals that a number of other hypothesized effects cannot find robust support. Simulations are used to assess the magnitude of the effect of regime type pre- and post-independence. Overall, the article contributes to theory development by investigating different institutional aspects of democracy and by distinguishing monadic and dyadic effects.<br /