52 research outputs found
Effects of Non-Sinusoidal Motion and Effective Angle of Attack on Energy Extraction Performance of a Fully- Activated Flapping Foil
Flapping foil energy harvesting systems are considered as highly competitive devices for conventional turbines. Several research projects have already been carried out to improve performances of such new devices. This paper is devoted to study effects of non-sinusoidal heaving trajectory, non-sinusoidal pitching trajectory, and the effective angle of attack on the energy extraction performances of a flapping foil operating at low Reynolds number (Re=1100). An elliptic function with an adjustable parameter S (flattening parameter) is used to simulate various sinusoidal and non-sinusoidal flapping trajectories. The flow around the flapping foil is simulated by solving Navier–Stokes equations using the commercial software Star CCM+ based on the finite-volume method. Overset mesh technique is used to model the flapping motion. The study is applied to the NACA0015 foil with the following kinetic parameters: a dimensionless heaving amplitude h0 = 1c, a shift angle between heaving and pitching motions f = 90 , a reduced frequency f = 0:14, and an effective angle of attack amax varying between 15 and 50 , corresponding to a pitching amplitude in the range q0 = 55:51 to 90:51 . The results show that, the non-sinusoidal trajectory affects considerably the energy extraction performances. For the reference case (sinusoidal heaving and pitching motions, Sh = Sq = 1), best performances are obtained for the effective angle of attack, amax = 40 . At small effective angle of attack amax 40 ), non-sinusoidal pitching motion has a negative effect. Performance improvement is quite limited with the combined motions non-sinusoidal heaving/sinusoidal pitching
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Prediction of cavitation and induced erosion inside a high-pressure fuel pump
The operation of a high-pressure, piston-plunger fuel pump, oriented for use in the common rail circuit of modern Diesel engines for providing fuel to the injectors is investigated in the present study from a numerical perspective. Both the suction and pressurization phases of the pump stroke were simulated with the overall flow time be-ing in the order of 12•10-3 s. The topology of the cavitating flow within the pump con-figuration was captured through the use of an Equation of State (EoS) implemented in the framework of a barotropic, homogeneous equilibrium model. Cavitation was found to set in within the pressure chamber as early as 0.2•10-3 s in the operating cycle, while the minimum liquid volume fraction detected was in the order of 60% during the sec-ond period of the valve opening. Increase of the in-cylinder pressure during the final stages of the pumping stroke lead to the collapse of the previously arisen cavitation structures and three layout locations, namely the piston edge, the valve/valve-seat re-gion and the outlet orifice, were identified as vulnerable to cavitation-induced erosion through the use of cavitation-aggressiveness indicators
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Performance of turbulence and cavitation models in prediction of incipient and developed cavitation
The aim of this article is to assess the impact of turbulence and cavitation models on the prediction of diesel injector nozzle flow. Two nozzles are examined, an enlarged one, operating at incipient cavitation, and an industrial injector tip, operating at developed cavitation. The turbulence model employed includes the re-normalization group k–ε, realizable k–ε and k–ω shear stress transport Reynolds-averaged Navier–Stokes models; linear pressure–strain Reynolds stress model and the wall adapting local eddy viscosity large eddy simulation model. The results indicate that all Reynolds-averaged Navier–Stokes and the Reynolds stress turbulence models have failed to predict cavitation inception due to their limitation to resolve adequately the low pressure existing inside vortex cores, which is responsible for cavitation development in this particular flow configuration. Moreover, Reynolds-averaged Navier–Stokes models failed to predict unsteady cavitation phenomena in the industrial injector. However, the wall adapting local eddy viscosity large eddy simulation model was able to predict incipient and developed cavitation, while also capturing the shear layer instability, vortex shedding and cavitating vortex formation. Furthermore, the performance of two cavitation methodologies is discussed within the large eddy simulation framework. In particular, a barotropic model and a mixture model based on the asymptotic Rayleigh–Plesset equation of bubble dynamics have been tested. The results indicate that although the solved equations and phase change formulation are different in these models, the predicted cavitation and flow field were very similar at incipient cavitation conditions. At developed cavitation conditions, standard cavitation models may predict unrealistically high liquid tension, so modifications may be essential. It is also concluded that accurate turbulence representation is crucial for cavitation in nozzle flows
Correlation of real-time haemoglobin oxygen saturation monitoring during photodynamic therapy with microvascular effects and tissue necrosis in normal rat liver
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Application of X-ray micro-computed tomography on high-speed cavitating diesel fuel flows
The flow inside a purpose built enlarged single-orifice nozzle replica is quantified using time-averaged X-ray micro-computed tomography (micro-CT) and high-speed shadowgraphy. Results have been obtained at Reynolds and cavitation numbers similar to those of real-size injectors. Good agreement for the cavitation extent inside the orifice is found between the micro-CT and the corresponding temporal mean 2D cavitation image, as captured by the high-speed camera. However, the internal 3D structure of the developing cavitation cloud reveals a hollow vapour cloud ring formed at the hole entrance and extending only at the lower part of the hole due to the asymmetric flow entry. Moreover, the cavitation volume fraction exhibits a significant gradient along the orifice volume. The cavitation number and the needle valve lift seem to be the most influential operating parameters, while the Reynolds number seems to have only small effect for the range of values tested. Overall, the study demonstrates that use of micro-CT can be a reliable tool for cavitation in nozzle orifices operating under nominal steady-state conditions
Foscan® (mTHPC) photosensitized macrophage activation: enhancement of phagocytosis, nitric oxide release and tumour necrosis factor-α-mediated cytolytic activity
Photodynamic activation of macrophage-like cells contributes to an effective outcome of photodynamic therapy (PDT) treatment. The possibility for an enhancement of macrophage activity by photosensitization with meta-tetra(hydroxyphenyl)chlorin (mTHPC) (1 μg ml−1) was studied in U937, monocyte cell line differentiated into macrophages (U937Φ cells). Phagocytic activity of U937Φ cells was evaluated by flow-cytometry monitoring of ingestion of fluorescein-labelled Escherichia coli particles. Increase in irradiation fluence up to 3.45 mJ cm−2 (corresponding irradiation time 15 s) resulted in significant increase in fluorescence signal (145%), while at higher light fluences the signal lowered down to the untreated control values. A light energy-dependent production of tumour necrosis factor-alpha (TNF-α) by photosensitized macrophages was further demonstrated using the L929 assay. The maximum TNF-α mediated cytolysis was observed at 28 mJ cm−2 and was 1.7-fold greater than that in control. In addition, we demonstrated a fluence-dependent increase in nitric oxide (NO) production by mTHPC-photosensitized macrophages. NO release increased gradually and reached a plateau after irradiation fluence of 6.9 mJ cm−2. Cytotoxicity measurements indicated that the observed manifestations of mTHPC-photosensitized macrophage activation took place under the sublethal light doses. The relevance of the present findings to clinical mTHPC-PDT is discussed. © 1999 Cancer Research Campaig
A cMUT Probe for Ultrasound-Guided Focused Ultrasound Targeted Therapy
International audienceUltrasound-mediated targeted therapy represents a promising strategy in the arsenal of modern therapy. Capacitive micromachined ultrasonic transducer (cMUT) technology could overcome some difficulties encountered by traditional piezoelectric transducers. In this study, we report on the design, fabrication, and characterization of an ultrasound-guided focused ultrasound (USgFUS) cMUT probe dedicated to preclinical evaluation of targeted therapy (hyperthermia, thermosensitive liposomes activation, and sonoporation) at low frequency (1 MHz) with simultaneous ultrasonic imaging and guidance (15 to 20 MHz). The probe embeds two types of cMUT arrays to perform the modalities of targeted therapy and imaging respectively. The wafer-bonding process flow employed for the manufacturing of the cMUTs is reported. One of its main features is the possibility of implementing two different gap heights on the same wafer. All the design and characterization steps of the devices are described and discussed, starting from the array design up to the first in vitro measurements: optical (microscopy) and electrical (impedance) measurements, arrays' electroacoustic responses, focused pressure field mapping (maximum peak-to-peak pressure = 2.5 MPa), and the first B-scan image of a wire-target phantom
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