72 research outputs found

    Analysis of Wind Power and Load Data at Multiple Time Scales

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    In this study we develop and apply new methods of data analysis for high resolution wind power and system load time series, to improve our understanding of how to characterize highly variable wind power output and the correlations between wind power and load. These methods are applied to wind and load data from the ERCOT region, and wind power output from the PJM and NYISO areas. We use a wavelet transform to apply mathematically well-defined operations of smoothing and differencing to the time series data. This approach produces a set of time series of the changes in wind power and load (or ?deltas?), over a range of times scales from a few seconds to approximately one hour. A number of statistical measures of these time series are calculated. We present sample distributions, and devise a method for fitting the empirical distribution shape in the tails. We also evaluate the degree of serial correlation, and linear correlation between wind and load. Our examination of the data shows clearly that the deltas do not follow a Gaussian shape; the distribution is exponential near the center and appears to follow a power law for larger fluctuations. Gaussian distributions are frequently used in modeling studies. These are likely to over-estimate the probability of small to moderate deviations. This in turn may lead to an over-estimation of the additional reserve requirement (hence the cost) for high penetration of wind. The Gaussian assumption provides no meaningful information about the real likelihood of large fluctuations. The possibility of a power law distribution is interesting because it suggests that the distribution shape for of wind power fluctuations may become independent of system size for large enough systems

    Pathogenic variants in SQOR encoding sulfide:quinone oxidoreductase are a potentially treatable cause of Leigh disease

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    Hydrogen sulfide, a signaling molecule formed mainly from cysteine, is catabolized by sulfide:quinone oxidoreductase (gene SQOR). Toxic hydrogen sulfide exposure inhibits complex IV. We describe children of two families with pathogenic variants in SQOR. Exome sequencing identified variants; SQOR enzyme activity was measured spectrophotometrically, protein levels evaluated by western blotting, and mitochondrial function was assayed. In family A, following a brief illness, a 4- year- old girl presented comatose with lactic acidosis and multiorgan failure. After stabilization, she remained comatose, hypotonic, had neurostorming episodes, elevated lactate, and Leigh- like lesions on brain imaging. She died shortly after. Her 8- year- old sister presented with a rapidly fatal episode of coma with lactic acidosis, and lesions in the basal ganglia and left cortex. Muscle and liver tissue had isolated decreased complex IV activity, but normal complex IV protein levels and complex formation. Both patients were homozygous for c.637G- >- A, which we identified as a founder mutation in the Lehrerleut Hutterite with a carrier frequency of 1 in 13. The resulting p.Glu213Lys change disrupts hydrogen bonding with neighboring residues, resulting in severely reduced SQOR protein and enzyme activity, whereas sulfide generating enzyme levels were unchanged. In family B, a boy had episodes of encephalopathy and basal ganglia lesions. He was homozygous for c.446delT and had severely reduced fibroblast SQOR enzyme activity and protein levels. SQOR dysfunction can result in hydrogen sulfide accumulation, which, consistent with its known toxicity, inhibits complex IV resulting in energy failure. In conclusion, SQOR deficiency represents a new, potentially treatable, cause of Leigh disease.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/162807/2/jimd12232.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/162807/1/jimd12232_am.pd

    Use of Frequency Response Metrics to Assess the Planning and Operating Requirements for Reliable Integration of Variable Renewable Generation

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    An interconnected electric power system is a complex system that must be operated within a safe frequency range in order to reliably maintain the instantaneous balance between generation and load. This is accomplished by ensuring that adequate resources are available to respond to expected and unexpected imbalances and restoring frequency to its scheduled value in order to ensure uninterrupted electric service to customers. Electrical systems must be flexible enough to reliably operate under a variety of"change" scenarios. System planners and operators must understand how other parts of the system change in response to the initial change, and need tools to manage such changes to ensure reliable operation within the scheduled frequency range. This report presents a systematic approach to identifying metrics that are useful for operating and planning a reliable system with increased amounts of variable renewable generation which builds on existing industry practices for frequency control after unexpected loss of a large amount of generation. The report introduces a set of metrics or tools for measuring the adequacy of frequency response within an interconnection. Based on the concept of the frequency nadir, these metrics take advantage of new information gathering and processing capabilities that system operators are developing for wide-area situational awareness. Primary frequency response is the leading metric that will be used by this report to assess the adequacy of primary frequency control reserves necessary to ensure reliable operation. It measures what is needed to arrest frequency decline (i.e., to establish frequency nadir) at a frequency higher than the highest set point for under-frequency load shedding within an interconnection. These metrics can be used to guide the reliable operation of an interconnection under changing circumstances

    Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial

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