Valorization of Carbonic Derivatives by Hydrogenation: A Challenge for the Development of Eco-Compatible Processes

International audienc

Cyclopentadienone Iron Tricarbonyl Complexes-Catalyzed Hydrogen Transfer in Water

International audienceThe development of efficient and low-cost catalytic systems is important for the replacementof robust noble metal complexes. The synthesis and application of a stable, phosphine-free,water-soluble cyclopentadienone iron tricarbonyl complex in the reduction of polarized doublebonds in pure water is reported. In the presence of cationic bifunctional iron complexes, a variety ofalcohols and amines were prepared in good yields under mild reaction conditions

A MOF-assisted phosphine free bifunctional iron complex for the hydrogenation of carbon dioxide, sodium bicarbonate and carbonate to formate

International audienceThe hydrogenation of carbon dioxide into formic acid (FA) with Earth-abundant metals is a vibrant research area because FA is an attractive molecule for hydrogen storage. We report a cyclopentadienyl iron tricarbonyl complex that provides up to 3000 turnover number for carbon dioxide hydrogenation when combined with a catalytic amount of the chromium dicarboxylate MOF MIL-53(Cr). To date, this is the highest turnover number reported in the presence of a phosphine-free iron complex

Valorization of Carbonic Derivatives by Hydrogenation: A Challenge for the Development of Eco-Compatible Processes

International audienc

Valorization of Carbonic Derivatives by Hydrogenation: A Challenge for the Development of Eco-Compatible Processes

International audienc

Hydrogenation of CO2, Hydrogenocarbonate and Carbonate to Formate in Water using Phosphine Free Bifunctional Iron Complexes.

International audienc

Iron Based Frustrated Lewis Pairs: from DFT to Applications in Alkylation of Ketones

International audienc

Amine Directed Palladium Catalyzed C‐H Halogenation of Phenylalanine Derivatives

International audienceAn efficient primary amine-directed palladium catalyzed C-H halogenation (X = I, Br, Cl) of phenylalanine derivatives is reported on a range of quaternary amino acid (AA) derivatives thanks to suited conditions employing trifluoroacetic acid as additive. The extension of this original native functionality-directed ortho-selective halogenation was even demonstrated with the more challenging native phenylalanine as tertiary AA

β-Strand Mimicry: Exploring Oligothienylpyridine Foldamers

International audienceProtein–protein interactions (PPIs) are involved in many cellular processes; consequently, the discovery of small molecules as modulators of PPIs has become an important challenge in medicinal chemistry. Structural mimetics of α‐helices, β‐turns or β‐strands could maintain or restore biological functions and should possess biological activity. At this time, the most challenging classes of PPIs are those mediated by β‐sheet interactions, which are implicated in a number of diseases. Only a few β‐strand mimics have been published to date. This study presents an evaluation of oligothienylpyridyl scaffolds in view of their ability for β‐strand mimicry. In this study, theoretical ring twist angle predictions for these scaffolds have been validated by X‐ray diffraction and molecular dynamics simulations with NMR constraints. Careful choice of substituent and heavy‐atom positions in the foldamer units opens the way to produce reasonably coplanar compounds mimicking β‐strand side‐chain distributio