1,867 research outputs found
Survival in pulmonary fibrosis combined with emphysema: likely defined by characteristics of specific patient subpopulations
Authors' Reply to letter from Cottin et al
Slip behavior in liquid films on surfaces of patterned wettability: Comparison between continuum and molecular dynamics simulations
We investigate the behavior of the slip length in Newtonian liquids subject
to planar shear bounded by substrates with mixed boundary conditions. The upper
wall, consisting of a homogenous surface of finite or vanishing slip, moves at
a constant speed parallel to a lower stationary wall, whose surface is
patterned with an array of stripes representing alternating regions of no-shear
and finite or no-slip. Velocity fields and effective slip lengths are computed
both from molecular dynamics (MD) simulations and solution of the Stokes
equation for flow configurations either parallel or perpendicular to the
stripes. Excellent agreement between the hydrodynamic and MD results is
obtained when the normalized width of the slip regions, , where is the (fluid) molecular diameter characterizing the
Lennard-Jones interaction. In this regime, the effective slip length increases
monotonically with to a saturation value. For and transverse flow configurations, the non-uniform interaction
potential at the lower wall constitutes a rough surface whose molecular scale
corrugations strongly reduce the effective slip length below the hydrodynamic
results. The translational symmetry for longitudinal flow eliminates the
influence of molecular scale roughness; however, the reduced molecular ordering
above the wetting regions of finite slip for small values of
increases the value of the effective slip length far above the hydrodynamic
predictions. The strong inverse correlation between the effective slip length
and the liquid structure factor representative of the first fluid layer near
the patterned wall illustrates the influence of molecular ordering effects on
slip in non-inertial flows.Comment: 12 pages, 10 figures Web reference added for animations:
http://www.egr.msu.edu/~priezjev/bubble/bubble.htm
Centrilobular emphysema combined with pulmonary fibrosis results in improved survival: a response
Better survival in combined pulmonary fibrosis and emphysema than in lone pulmonary fibrosis: bias or reality? A response to Centrilobular emphysema combined with pulmonary fibrosis results in improved survival by Todd et al., Fibrogenesis & Tissue Repair 2011, 4:6
M. ulcerans infection diagnosis by fine needle aspiration
Date du colloque : 04/2009</p
Report of the laboratory confirmation of cases from the CDTUB Pobé, Benin
In 2009, 420 diagnostic samples (corresponding to 301 patients suspected of M. ulcerans infection) from the Centre de Dépistage et de Traitement de l’Ulcère de Buruli of Benin were subjected to IS2404 PCR at the Centre Hospitalier Universitaire of Angers. 180 samples (corresponding to 141 patients) were confirmed positive to M. ulcerans infection by PCR
Disruption of Candida albicans IFF4 gene involves modifications of the cell electrical surface properties.
During the past two decades, the prevalence of candidiasis has increased markedly and Candida albicans has now become one of the most important causes of nosocomial infections, especially after colonization of inert surfaces such as catheters or prostheses. In a previous report, we demonstrated the overexpression of 35 unidentified genes in response to adherence of C. albicans germ tubes to plastic. Therefore, a bioinformatic analysis was performed searching for genes encoding surface proteins potentially involved in adherence. Nineteen genes were thus selected, and one of them, CaIFF4, was further investigated. The deduced protein of this CaIFF4 gene revealed a glycosylphosphatidylinositol (GPI)-anchored site as well as the presence of a N-terminal signal peptide. Disruption of both alleles of CaIFF4 gene from C. albicans parent strain BWP17 was performed by PCR method. Then investigations of properties of null mutant for CaIFF4 gene showed a decrease of adherence of germ tubes to plastic in comparison to the parent strain BWP17. Besides, electrophoretic mobilities of germ tubes of CaIFF4 null mutant and of parental strain BWP17 were measured. Data were then analysed with soft particles analysis theory. Results point out a less important electrophoretic mobility of germ tubes of CaIFF4 null mutant in comparison to germ tubes of BWP17 parental strain
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