Predictive value of PET response combined with baseline metabolic tumor volume in peripheral T-cell lymphoma patients

Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of aggressive non-Hodgkin lymphomas with poor outcomes on current therapy. We investigated whether response assessed with PET/CT combined with baseline total metabolic tumor volume (TMTV) could detect early relapse or refractory disease. Methods: From 7 European centers, 140 patients with nodal PTCL who underwent baseline PET/CT were selected. Forty-three had interim PET (iPET) performed after 2 cycles (iPET2), 95 had iPET performed after 3 or 4 cycles (iPET3/4), and 96 had end-of-treatment PET (eotPET). Baseline TMTV was computed with a 41% SUVmax threshold, and PET response was reported using the Deauville 5-point scale. Results: With a median of 43 mo of follow-up, the 2-y progression-free survival (PFS) and overall survival (OS) were 51% and 67%, respectively. iPET2-positive patients (Deauville score ≥ 4) had a significantly worse outcome than iPET2-negative patients (P 230 cm3 and iPET3/4-negative [59%/84%]; TMTV ≤ 230 cm3 and iPET3/4-positive [42%/50%]; TMTV > 230 cm3 and iPET3/4-positive [0%/18%]). Conclusion: iPET response is predictive of outcome and allows early detection of high-risk PTCL patients. Combining iPET with TMTV improves risk stratification in individual patients

Predictive value of spleen and bone marrow involvement detected on baseline FDG-PET/CT in peripheral T cell lymphoma (PTCL)

International audienc

Baseline metabolic tumor volume predicts outcome in high tumor burden follicular lymphoma : a pooled analysis of three multicentre studies

International audienc

Valeur pronostique de la classification GCB/ABC déterminée par RT-MLPA associée à la TEP dans les lymphomes B diffus à grandes cellules

International audienc

Pet imaging

FDG-PET has significantly contributed to improve the management of most aggressive and Hodgkin lymphomas. Although more heterogeneous, FDG avidity has been demonstrated also for indolent lymphomas, leading to increased use of functional imaging in this setting. In this chapter we review available data about the contribution of FDG-PET for staging and response assessment and for the identification of histologic transformation of follicular lymphomas and of other low-grade B-cell lymphoma subtypes