Search for pulsations in the LMXB EXO 0748-676

We present here results from our search for X-ray pulsations of the neutron star in the low mass X-ray binary EXO 0748-676 at a frequency near a burst-oscillation frequency of 44.7 Hz. Using the observations made with the Proportional Counter Array on board the Rossi X-ray Timing Explorer we did not find any pulsations in the frequency band of 44.4 Hz to 45.0 Hz and obtained a 3\sigma upper limit of 0.47 % on the pulsed fraction for any possible underlying pulsation in this frequency band.Comment: Accepted for publication in "Research in Astronomy and Astrophysics", 7 pages, 3 figure

The Ursinus College Investment Management Company Newsletter, Spring 2019

Inside this Issue: What\u27s New? Brief History of Ursinus What Our Newest Students are Saying What are They Saying? Vanguard Field Trip 2019 Fund Performance Looking Forward Fundraising & Galler

CAN INERTIAL MEASUREMENT UNITS BE USED TO VALIDLY MEASURE PELVIS AND THORAX MOTION DURING CRICKET BOWLING?

Identifying lumbar injury risk amongst cricket bowlers is a challenge to those involved in the sport. Bowling technique injury risk factors concerning thoracic and pelvic motion have been identified by previous research that used three-dimensional (3D) retro-reflective (RR) motion analysis. Inertial measurement units (IMUs) are considered a feasible and more portable means of 3D motion analysis. However, the validity of IMU measurement of thorax and pelvis movement during bowling has not yet been fully determined. This study aimed to achieve this by comparing concurrent IMU and RR angle outputs. Results suggest that when RR coordinate systems are aligned with IMUs’ there are no significant differences in cricket bowling relevant angle outputs. However, some differences arise when IMUs are compared to the anatomically derived RR angle outputs typically used in 3D analysis

Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.The interaction of IGF-II with the insulin receptor (IR) and type 1 insulin-like growth factor receptor (IGF-1R) has recently been identified as potential therapeutic target for the treatment of cancer. Understanding the interactions of IGF-II with these receptors is required for the development of potential anticancer therapeutics. This work describes an efficient convergent synthesis of native IGF-II and two nonnative IGF-II analogues with coumarin fluorescent probes incorporated at residues 19 and 28. These fluorescent analogues bind with nanomolar affinities to the IGF-1R and are suitable for use in fluorescence resonance energy transfer (FRET) studies. From these studies the F19Cou IGF-II and F28Cou IGF-II proteins were identified as good probes for investigating the binding interactions of IGF-II with the IGF-1R and its other high affinity binding partners

Raman scattering from phonons and magnons in RFe3)BO3)4

Inelastic light scattering spectra of several members of the RFe3(BO3)4 family reveal a cascade of phase transitions as a function of temperature, starting with a structural, weakly first order, phase transition followed by two magnetic phase transitions. Those consist of the ordering of the Fe-spin sublattice revealed by all the compound, and a subsequent spin-reorientational transition for GdFe3(BO3)4. The Raman data evidence a strong coupling between the lattice and magnetic degrees of freedom in these borates. The Fe-sublattice ordering leads to a strong suppression of the low energy magnetic scattering, and a multiple peaked two-magnon scattering continuum is observed. Evidence for short-range correlations is found in the `paramagnetic' phase by the observation of a broad magnetic continuum in the Raman data, which persists up to surprisingly high temperatures.Comment: 17 pages, 13 figure

Ursinus College Student-Managed Investment Fund Prospectus, Fall 2018

This prospectus contains a performance summary for previous stocks and endowment funds as well as strategy and analysis for the following new stocks in the managed fund: American Woodmark Corporation, Comtech Telecommunications Corp. and LGL Group, Inc

First observations with SuperCam and future plans

Supercam is a 345 GHz, 64-pixel heterodyne imaging array for the Heinrich Hertz Submillimeter Telescope (HHSMT). By integrating SIS mixer devices with Low Noise Ampliers (LNAs) in 8 - 1x8 pixel modules, the size needed for the cryostat and the complexity of internal wiring is signicantly reduced. All subsystems including the optics, cryostat, bias system, IF boxes, and spectrometer have been integrated for all 64 pixels. In the spring of 2012, SuperCam was installed on the HHSMT for an engineering run where it underwent system level tests and performed rst light observations. In the fall of 2012 SuperCam will begin a 500 square degree survey of the Galactic Plane in ^(12)CO J=3-2. This large-scale survey will help answer fundamental questions about the formation, physical conditions, and energetics of molecular clouds within the Milky Way. The data set will be available via the web to all interested researchers

Pulmonary function deficits in newborn screened infants with cystic fibrosis managed with standard UK care are mild and transient

With the advent of novel designer molecules for cystic fibrosis (CF) treatment, there is huge need for early-life clinical trial outcomes, such as infant lung function (ILF). We investigated the degree and tracking of ILF abnormality during the first 2 years of life in CF newborn screened infants. Forced expiratory volume in 0.5 s (FEV₀.₅), lung clearance index (LCI) and plethysmographic functional residual capacity were measured at ∼3 months, 1 year and 2 years in 62 infants with CF and 34 controls. By 2 years there was no significant difference in FEV₀.₅ z-score between CF and controls, whereas mean LCI z-score was 0.81 (95% CI 0.45–1.17) higher in CF. However, there was no significant association between LCI z-score at 2 years with either 3-month or 1-year results. Despite minimal average group changes in any ILF outcome during the second year of life, marked within-subject changes occurred. No child had abnormal LCI or FEV₀.₅ on all test occasions, precluding the ability to identify “high-risk” infants in early life. In conclusion, changes in lung function are mild and transient during the first 2 years of life in newborn screened infants with CF when managed according to a standardised UK treatment protocol. Their potential role in tracking disease to later childhood will be ascertained by ongoing follow-up

Connectivity-Guided Theta Burst Transcranial Magnetic Stimulation Versus Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Moderate to Severe Depression: Magnetic Resonance Imaging Protocol and SARS-CoV-2–Induced Changes for a Randomized Double-blind Controlled Trial

Background:Depression is a significant health and economic burden. In approximately one third of patients, depression is resistant to first line treatments and therefore it is essential that alternative treatments are found. Transcranial magnetic stimulation (TMS) is a neuromodulatory treatment involving the application of magnetic pulses to the brain that is approved in the UK and the US in treatment resistant depression. This trial aims to compare the clinical effectiveness, cost-effectiveness and mechanism of action between standard treatment repetitive TMS (rTMS) targeted at the F3 EEG site, with a newer treatment – a type of TMS called theta-burst stimulation (TBS) targeted based on measures of functional brain connectivity. This protocol outlines the brain imaging acquisition and analysis for the BRIGhTMIND trial that is used to create personalised TMS targets and answer the proposed mechanistic hypotheses.Objective:The objectives of the imaging arm of the BRIGhTMIND study are to identify functional and neurochemical brain signatures indexing the treatment mechanisms of rTMS and cgiTBS and to identify imaging-based markers predicting response to treatment.Methods:The study is a randomised double-blind controlled trial with 1:1 allocation to either 20 sessions of a) TBS or b) standard rTMS. Multimodal magnetic resonance imaging (MRI) is acquired per participant at baseline (prior to TMS treatment) with T1-weighted and task-free functional MRI during rest (rsfMRI) utilised to estimate TMS targets. For participants enrolled in the mechanistic substudy additional diffusion-weighted, sequences are acquired at baseline and at post-treatment follow-up 16 weeks after treatment randomisation. Core datasets of T1-weighted and task-free functional MRI during rest (rsfMRI) are acquired for all participants and utilised to estimate TMS targets. Additional sequences of arterial spin labelling, magnetic resonance spectroscopy and diffusion-weighted images are acquired dependent on recruitment site for mechanistic evaluation. Standard rTMS treatment is targeted at the F3 electrode site over the left dorsolateral prefrontal cortex whilst TBS treatment is guided using the coordinate of peak effective connectivity from the right anterior insula to the left dorsolateral prefrontal cortex. Both treatment targets benefit from a level of MRI-guidance but only TBS is provided with precision targeting based on functional brain connectivity.Results:Recruitment began January 2019 and is ongoing. Data collection is expected to continue until January 2023.Conclusions:This trial will determine the impact of precision MRI guidance on rTMS treatment, and furthermore, assess the neural mechanisms underlying this treatment in treatment resistant depressed patients. Clinical Trial: International Standard Randomized Controlled Trial Number (ISRCTN) 19674644; https://www.isrctn.com/ISRCTN19674644. Registered 2nd October 2018