59 research outputs found
Gastrointestinal effects of soluble guanylate cyclase activation by NO-independent compounds and by NO delivery via nitrite
Pressurized intraperitoneal aerosol chemotherapy (PIPAC), a new surgical technique for the treatment of unresectable peritoneal carcinomatosis
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Establishment of a rat ovarian peritoneal metastasis model to study pressurized intraperitoneal aerosol chemotherapy (PIPAC)
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Effects of electrostatic precipitation on IP drug distribution and tissue penetration of nanoparticles
Intraperitoneal aerosolization of albumin-stabilized paclitaxel nanoparticles (Abraxaneâ„¢) for peritoneal carcinomatosis : a phase I first-in-human study
Background: Nanoparticles hold considerable promise for aerosol-based intraperitoneal delivery in patients with carcinomatosis. Recently, results from preclinical and early clinical trials suggested that albumin-bound paclitaxel (ABP, Abraxane (TM)) may result in superior efficacy in the treatment of peritoneal metastases (PM) compared to the standard solvent-based paclitaxel formulation (Taxol (TM)). Here, we propose a phase I study of pressurized intraperitoneal aerosol chemotherapy (PIPAC) using ABP in patients with upper Gastrointestinal, breast, or ovarian cancer.
Methods: Eligible patients with advanced, biopsy-proven PM from ovarian, breast, gastric, hepatobiliary, or pancreatic origin will undergo three PIPAC treatments using ABP with a 4-week interval. The dose of ABP will be escalated from 35 to 140 mg/m(2) using a Bayesian approach until the maximally tolerated dose is determined. The primary end point is dose-limiting toxicity. Secondary analyses include surgical morbidity, non-access rate, pharmacokinetic and pharmacodynamic analyses, quality of life, and exploratory circulating biomarker analyses.
Discussion: ABP holds considerable promise for intraperitoneal aerosol delivery. The aim of this study is to determine the dose level for future randomized phase II trials using ABP in PIPAC therapy
In vitro study of aerosol droplet impact on the peritoneal surface after nebulization using the CapnoPen device
Mechanism of relaxation and interaction with nitric oxide of the soluble guanylate stimulator BAY 41-2272 in mouse gastric fundus and colon
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