1,055 research outputs found
Mott transition of fermionic atoms in a three-dimensional optical trap
We study theoretically the Mott metal-insulator transition for a system of
fermionic atoms confined in a three-dimensional optical lattice and a harmonic
trap. We describe an inhomogeneous system of several thousand sites using an
adaptation of dynamical mean field theory solved efficiently with the numerical
renormalization group method. Above a critical value of the on-site
interaction, a Mott-insulating phase appears in the system. We investigate
signatures of the Mott phase in the density profile and in time-of-flight
experiments.Comment: 4 pages and 5 figure
Magnetotransport through a strongly interacting quantum dot
We study the effect of a magnetic field on the conductance through a strongly
interacting quantum dot by using the finite temperature extension of Wilson's
numerical renormalization group method to dynamical quantities. The quantum dot
has one active level for transport and is modelled by an Anderson impurity
attached to left and right electron reservoirs. Detailed predictions are made
for the linear conductance and the spin-resolved conductance as a function of
gate voltage, temperature and magnetic field strength. A strongly coupled
quantum dot in a magnetic field acts as a spin filter which can be tuned by
varying the gate voltage. The largest spin-filtering effect is found in the
range of gate voltages corresponding to the mixed valence regime of the
Anderson impurity model.Comment: Revised version, to appear in PRB, 4 pages, 4 figure
Sum-rule Conserving Spectral Functions from the Numerical Renormalization Group
We show how spectral functions for quantum impurity models can be calculated
very accurately using a complete set of ``discarded'' numerical renormalization
group eigenstates, recently introduced by Anders and Schiller. The only
approximation is to judiciously exploit energy scale separation. Our derivation
avoids both the overcounting ambiguities and the single-shell approximation for
the equilibrium density matrix prevalent in current methods, ensuring that
relevant sum rules hold rigorously and spectral features at energies below the
temperature can be described accurately.Comment: 4 pages + 1 page appendix, 2 figure
The numerical renormalization group method for quantum impurity systems
In the beginning of the 1970's, Wilson developed the concept of a fully
non-perturbative renormalization group transformation. Applied to the Kondo
problem, this numerical renormalization group method (NRG) gave for the first
time the full crossover from the high-temperature phase of a free spin to the
low-temperature phase of a completely screened spin. The NRG has been later
generalized to a variety of quantum impurity problems. The purpose of this
review is to give a brief introduction to the NRG method including some
guidelines of how to calculate physical quantities, and to survey the
development of the NRG method and its various applications over the last 30
years. These applications include variants of the original Kondo problem such
as the non-Fermi liquid behavior in the two-channel Kondo model, dissipative
quantum systems such as the spin-boson model, and lattice systems in the
framework of the dynamical mean field theory.Comment: 55 pages, 27 figures, submitted to Rev. Mod. Phy
Recent advancement in the search of innovative antiprotozoal agents targeting trypanothione metabolism
Leishmania and Trypanosoma parasites are responsible for the challenging neglected tropical diseases leishmaniases, Chagas disease, and human African trypanosomiasis, which account for up to 40,000 deaths annually mainly in developing countries. Current chemotherapy relies on drugs with significant limitations in efficacy and safety, prompting the urgent need to explore innovative approaches to improve the drug discovery pipeline. The unique trypanothione-based redox pathway, which is absent in human hosts, is vital for all trypanosomatids and offers valuable opportunities to guide the rational development of specific, broad-spectrum and innovative anti-trypanosomatid agents. Major efforts focused on the key metabolic enzymes trypanothione synthetase-amidase and trypanothione reductase, whose inhibition should affect the entire pathway and, finally, parasite survival. Herein, we will report and comment on the most recent studies in the search for enzyme inhibitors, underlining the promising opportunities that have emerged so far to drive the exploration of future successful therapeutic approaches
Real-Time-RG Analysis of the Dynamics of the Spin-Boson Model
Using a real-time renormalization group method we determine the complete
dynamics of the spin-boson model with ohmic dissipation for coupling strengths
. We calculate the relaxation and dephasing time, the
static susceptibility and correlation functions. Our results are consistent
with quantum Monte Carlo simulations and the Shiba relation. We present for the
first time reliable results for finite cutoff and finite bias in a regime where
perturbation theory in or in tunneling breaks down. Furthermore, an
unambigious comparism to results from the Kondo model is achieved.Comment: 4 pages, 5 figures, 1 tabl
Transport Coefficients of the Anderson Model via the Numerical Renormalization Group
The transport coefficients of the Anderson model are calculated by extending
Wilson's NRG method to finite temperature Green's functions. Accurate results
for the frequency and temperature dependence of the single--particle spectral
densities and transport time are obtained and used to extract
the temperature dependence of the transport coefficients in the strong
correlation limit. The low temperature anomalies in the resistivity, ,
thermopower, , thermal conductivity and Hall coefficient,
, are discussed. All quantities exhibit the expected Fermi liquid
behaviour at low temperature with power law dependecies on in very
good agreement with analytic results based on Fermi liquid theory. Scattering
of conduction electrons in higher, , angular momentum channels is also
considered and an expression is derived for the corresponding transport time
and used to discuss the influence of non--resonant scattering on the transport
properties.Comment: 45 pages, RevTeX, 28 figures, available on reques
Kondo proximity effect: How does a metal penetrate into a Mott insulator?
We consider a heterostructure of a metal and a paramagnetic Mott insulator
using an adaptation of dynamical mean field theory to describe inhomogeneous
systems. The metal can penetrate into the insulator via the Kondo effect. We
investigate the scaling properties of the metal-insulator interface close to
the critical point of the Mott insulator. At criticality, the quasiparticle
weight decays as 1/x^2 with distance x from the metal within our mean field
theory. Our numerical results (using the numerical renormalization group as an
impurity solver) show that the prefactor of this power law is extremely small.Comment: 4 pages, 3 figure
Kondo effect in a magnetic field and the magnetoresistivity of Kondo alloys
The effect of a magnetic field on the spectral density of a
Kondo impurity is investigated at zero and finite temperatures by using
Wilson's numerical renormalization group method. A splitting of the total
spectral density is found for fields larger than a critical value
, where is the Kondo scale. The splitting
correlates with a peak in the magnetoresistivity of dilute magnetic alloys
which we calculate and compare with the experiments on
. The linear magnetoconductance of quantum
dots exhibiting the Kondo effect is also calculated.Comment: 4 pages, 4 eps figure
Evaluating the expression of urokinase and tissue leukocyte being in benign and malignant breast disease
Introduction: Our objectives is to show that the expression of uPA leukocyte could be considered, in the future, as a marker of
the expression of uPA in the malignant tissue and therefore a potential indicator of prognosis.
Methods: We examined the expression of uPa in leukocytes and tissues of three groups of women: with breast cancer; with
benign breast lesion and healthy women (control group). We used RT Real Time PCR assay. The expression of urokinase is
significantly higher in malignant breast lumps compared to benign lesions. However, in women with carcinoma of the breast,
malignant tissue expresses higher amounts of uPA than the healthy counterpart. There are no statistically significant differences in
the expression of uPA, between tissues taken from women with benign lesions. The lymphocytes taken from healthy volunteers
show a level of expression of uPA significantly lower than the other tested samples Lymphocytes extracted from cancer patients
express higher amounts of uPA compared to lymphocytes belonging to women with benign breast lesions. The expression of uPA
was compared with the clinical and biological parameters commonly used in clinical practice for the definition of the prognosis.
The only exception found, concerns those tumors characterized by the simultaneous negativity for estrogen receptors,
progesterone and HER2 (state of triple negative), in which the expression of uPA is very high.
Results and conclusions: Our data show that uPA expressed by leukocytes of each individual patient is the mirror image of the
one expressed by malignant nodular uPA.Introduction: Our objectives is to show that the expression of uPA leukocyte could be considered, in the future, as a marker of
the expression of uPA in the malignant tissue and therefore a potential indicator of prognosis.
Methods: We examined the expression of uPa in leukocytes and tissues of three groups of women: with breast cancer; with
benign breast lesion and healthy women (control group). We used RT Real Time PCR assay. The expression of urokinase is
significantly higher in malignant breast lumps compared to benign lesions. However, in women with carcinoma of the breast,
malignant tissue expresses higher amounts of uPA than the healthy counterpart. There are no statistically significant differences in
the expression of uPA, between tissues taken from women with benign lesions. The lymphocytes taken from healthy volunteers
show a level of expression of uPA significantly lower than the other tested samples Lymphocytes extracted from cancer patients
express higher amounts of uPA compared to lymphocytes belonging to women with benign breast lesions. The expression of uPA
was compared with the clinical and biological parameters commonly used in clinical practice for the definition of the prognosis.
The only exception found, concerns those tumors characterized by the simultaneous negativity for estrogen receptors,
progesterone and HER2 (state of triple negative), in which the expression of uPA is very high.
Results and conclusions: Our data show that uPA expressed by leukocytes of each individual patient is the mirror image of the
one expressed by malignant nodular uPA
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