Tribute to the Poet: Fr. Michael Costanzo, Cri de Coueur

Contains excerpts from Fr. Michael Costanzo\u27s poetry book Water Lilies: Whirlwind, Section 1, No. 2, No. 5, Desolation the Queen, No. 11 Rita, and No. 9 Horizon. In lieu of an abstract, below is the essay\u27s first paragraph. Anyone who had the pleasure of conversing with Fr. Michael, either over coffee in his office or at the various little cafes he favored, knew him to be a very complicated man. My favorite conversations were about his love for opera (for which I remain only a neophyte) and his poetry. Ultimately, our talks led him to give me the privilege of writing the forward to his collection of poems Water Lilies. This is what I best remember of Fr. Michael and can think of no better tribute to him than to examine the complexity of his thoughts found in this particular work. Written over three decades, do not be tempted to see the change in voice as an evolution of spirit, his reflections changing with age. It is, rather, much like his beloved opera -- images of life filled with joy, despair, hope, and redemption

How Does The Videogame Industry Abuse Workers

The videogame development industry is rampant with labor and sexual abuse. These forms abuse go unaddressed within mainstream media. Big-name companies backed by large corporations force their employees into unpaid overtime in terrible working conditions. Female game developers are typically paid less due to a game developers are typically paid less due to a game developers are typically paid less due to a gender bias and are at higher risk of sexual gender bias and are at higher risk of sexual gender bias and are at higher risk of sexual assault both of which get swept under the rug to keep a good reputation in the industry. This research reviews articles and journals to discuss research reviews articles and journals to discuss research reviews articles and journals to discuss and analyze current worker abuse in the and analyze current worker abuse in the and analyze current worker abuse in the videogame industry

Rex1p Deficiency Leads to Accumulation of Precursor Initiator tRNA\u3csup\u3eMet\u3c/sup\u3e and Polyadenylation of Substrate RNAs in \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e

A synthetic genetic array was used to identify lethal and slow-growth phenotypes produced when a mutation in TRM6, which encodes a tRNA modification enzyme subunit, was combined with the deletion of any non-essential gene in Saccharomyces cerevisiae. We found that deletion of the REX1 gene resulted in a slow-growth phenotype in the trm6-504 strain. Previously, REX1 was shown to be involved in processing the 3′ ends of 5S rRNA and the dimeric tRNAArg-tRNAAsp. In this study, we have discovered a requirement for Rex1p in processing the 3′ end of tRNAiMet precursors and show that precursor tRNAiMet accumulates in a trm6-504 rex1Δ strain. Loss of Rex1p results in polyadenylation of its substrates, including tRNAiMet, suggesting that defects in 3′ end processing can activate the nuclear surveillance pathway. Finally, purified Rex1p displays Mg2+-dependent ribonuclease activity in vitro, and the enzyme is inactivated by mutation of two highly conserved amino acids

Recurring patterns in stationary intervals of abdominal uterine electromyograms during gestation

Abdominal uterine electromyograms (uEMG) studies have focused on uterine contractions to describe the evolution of uterine activity and preterm birth (PTB) prediction. Stationary, non-contracting uEMG has not been studied. The aim of the study was to investigate the recurring patterns in stationary uEMG, their relationship with gestation age and PTB, and PTB predictivity. A public database of 300 (38 PTB) three-channel (S1-S3) uEMG recordings of 30 min, collected between 22 and 35 weeks' gestation, was used. Motion and labour contraction-free intervals in uEMG were identified as 5-min weak-sense stationarity intervals in 268 (34 PTB) recordings. Sample entropy (SampEn), percentage recurrence (PR), percentage determinism (PD), entropy (ER), and maximum length (L MAX) of recurrence were calculated and analysed according to the time to delivery and PTB. Random time series were generated by random shuffle (RS) of actual data. Recurrence was present in actual data (p<0.001) but not RS. In S3, PR (p<0.005), PD (p<0.01), ER (p<0.005), and L MAX (p<0.05) were higher, and SampEn lower (p<0.005) in PTB. Recurrence indices increased (all p<0.001) and SampEn decreased (p<0.01) with decreasing time to delivery, suggesting increasingly regular and recurring patterns with gestation progression. All indices predicted PTB with AUC≥0.62 (p<0.05). Recurring patterns in stationary non-contracting uEMG were associated with time to delivery but were relatively poor predictors of PTB