Five-level selective harmonic elimination PWM strategies and multicarrier phase-shifted sinusoidal PWM: A comparison

The multicarrier phase-shifted sinusoidal pulse-width modulation (MPS-SPWM) technique is well-known for its important advantage of offering an increased overall bandwidth as the number of carriers multiplied with their equal frequency directly controls the location of the dominant harmonics. In this paper, a five-level (line-to-neutral) multilevel selective harmonic elimination PWM (MSHE-PWM) strategy based on an equal number of switching transitions when compared against the previously mentioned technique is proposed. It is assumed that the four triangular carriers of the MPS-SPWM method have nine per unit frequency resulting in seventeen switching transitions for every quarter period. Requesting the same number of transitions from the MSHE-PWM allows the control of sixteen non-triplen harmonics. It is confirmed that the proposed MSHE-PWM offers significantly higher converter bandwidth along with higher modulation operating range. Selected results are presented to confirm the effectiveness of the proposed technique

Embedded finite-element solver for computation of brushless permanent-magnet motors

This paper describes the theory underlying the formulation of a “minimum set” of finite-element solutions to be used in the design and analysis of saturated brushless permanent-magnet motors. The choice of finite-element solutions is described in terms of key points on the flux–MMF diagram. When the diagram has a regular shape, a huge reduction in finite-element analysis is possible with no loss of accuracy. If the loop is irregular, many more solutions are needed. This paper describes an efficient technique in which a finite-element solver is associated with a classical $d$– $q$-axis circuit model in such a way that the number of finite-element solutions in one electrical half-cycle can be varied between 1 and 360. The finite-element process is used to determine not only the average torque but also the saturated inductances as the rotor rotates

Simulation and Analysis of Magnetisation Characteristics of Interior Permanent Magnet Motors

Modern permanent magnet (PM) synchronous brushless machines often have magnetic circuits in which the patterns of saturation are complex and highly variable with the position of the rotor. The classical phasor diagram theory of operation relies on the assumption of sinusoidal variation of flux-linkage with rotor position, and neglects the non-linear effects that arise in different operating states. The finite element method is a useful tool for detailed magnetic analysis, but it is important to verify simulation results by direct measurement of the magnetic characteristics of the motor, in terms of “magnetisation curves” of current and flux-linkage. This paper presents results from finite element simulations to determine the magnetisation in a split-phase interior permanent magnet (IPM) motor. Investigation has been made to determine the effects of the rotor geometry on the synchronous reactances and airgap flux distribution. Comparisons are made with a second IPM motor with a different rotor configuration.

Ionomer content optimization in nickel-iron-based anodes with and without ceria for anion exchange membrane water electrolysis

Hydrogen production from anion exchange membrane water electrolysis (AEMWE) is an efficient cost-effective solution to renewable energy storage. Contrary to proton exchange membrane (PEM) electrolysis, AEMWE requires further optimization of its cell design, particularly for the kinetically unfavourable oxygen evolution anode half-cell reaction (OER). In this work we optimize the commercial Fumatech fumion ionomer content in AEMWE anodes using nickel (Ni) nanoparticles (NP) synthesized by chemical reduction. The optimal ionomer content is then applied to Ni-iron (Fe)-based NPs with and without ceria (CeO2), all prepared using the same method. Scanning Electron Microscopy (SEM) of the resulting electrode surfaces, Particle-size Distribution (PSD) of the catalyst inks, and in-situ testing of the monometallic Ni NPs show that the best and most active catalytic layer is obtained using 15 wt% ionomer. AEMWE performance and short-term durability are evaluated in different concentrations of potassium hydroxide (KOH), where the Ni90Fe10 is the best performing Ni-based electrode showing 1.72 V at 0.8 A cm−2 in 1 M KOH after IR-correction, and a degradation rate of 3.3 mV h−1. The addition of ceria to the Ni-based catalysts shows more consistent mass transfer over time likely due to more efficient water transport and bubble release.acceptedVersio

Effect of mutual coupling on torque production in switched reluctance motors

In many cases, the normal operation of switched reluctance machines requires excitation of two or more phases simultaneously. When multiple phases are conducting simultaneously, the flux paths from each phase will overlap, which may lead to localized saturation. In such cases, the flux linkage must be considered a function not just of the current in the test winding but of all excited windings. The degree of mutual coupling between phases influences the per-phase magnetization curves and torque characteristics. In machines with even phase numbers, the degree of mutual coupling between phases varies due to discontinuities in the phase polarity arrangement. From nonlinear finite element simulations, it is possible to compare the i - loop diagrams under single-phase and multiphase excitations, and hence the torque produced. The mutual flux linkage from each phase can be calculated separately for each rotor position using the frozen permeability method, to further analyze the mutual coupling effects. For a given excitation current profile, the torque can be maximized by careful arrangement of the phase polarities

Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach

Molecules that stabilize protein-protein interactions (PPIs) are invaluable as tool compounds for biophysics and (structural) biology, and as starting points for molecular glue drug discovery. However, identifying initial starting points for PPI stabilizing matter is highly challenging, and chemical optimization is labor-intensive. Inspired by chemical crosslinking and reversible covalent fragment-based drug discovery, we developed an approach that we term “molecular locks” to rapidly access molecular glue-like tool compounds. These dual-covalent small molecules reversibly react with a nucleophilic amino acid on each of the partner proteins to dynamically crosslink the protein complex. The PPI between the hub protein 14-3-3 and estrogen-related receptor γ (ERRγ) was used as a pharmacologically relevant case study. Based on a focused library of dual-reactive small molecules, a molecular glue tool compound was rapidly developed. Biochemical assays and X-ray crystallographic studies validated the ternary covalent complex formation and overall PPI stabilization via dynamic covalent crosslinking. The molecular lock approach is highly selective for the specific 14-3-3/ERRγ complex, over other 14-3-3 complexes. This selectivity is driven by the interplay of molecular reactivity and molecular recognition of the composite PPI binding interface. The long lifetime of the dual-covalent locks enabled the selective stabilization of the 14-3-3/ERRγ complex even in the presence of several other competing 14-3-3 clients with higher intrinsic binding affinities. The molecular lock approach enables systematic, selective, and potent stabilization of protein complexes to support molecular glue drug discovery.</p

Molecular basis and dual ligand regulation of tetrameric Estrogen Receptor α/14-3-3ζ protein complex

Therapeutic strategies targeting Nuclear Receptors (NRs) beyond their endogenous ligand binding pocket have gained significant scientific interest, driven by a need to circumvent problems associated with drug resistance and pharmacological profile. The hub protein 14-3-3 is an endogenous regulator of various NRs, providing a novel entry point for small molecule modulation of NR activity. Exemplified, 14-3-3 binding to the C-terminal F-domain of the Estrogen Receptor alpha (ERα), and small molecule stabilization of the ERα/14-3-3ζ protein complex by the natural product Fusicoccin A (FC-A), was demonstrated to downregulate ERα-mediated breast cancer proliferation. This presents a novel drug discovery approach to target ERα, however, structural and mechanistic insights into ERα/14-3-3 complex formation are lacking. Here, we provide an in-depth molecular understanding of the ERα/14-3-3ζ complex by isolating 14-3-3ζ in complex with an ERα protein construct comprising its Ligand Binding Domain (LBD) and phosphorylated F-domain. Bacterial co-expression and co-purification of the ERα/14-3-3ζ complex, followed by extensive biophysical and structural characterization, revealed a tetrameric complex between the ERα homodimer and the 14-3-3ζ homodimer. 14-3-3ζ binding to ERα, and ERα/14-3-3ζ complex stabilization by FC-A, appeared to be orthogonal to ERα endogenous agonist (E2) binding, E2-induced conformational changes, and cofactor recruitment. Similarly, the ERα antagonist 4-hydroxytamoxifen inhibited cofactor recruitment to the ERα LBD while ERα was bound to 14-3-3ζ. Furthermore, stabilization of the ERα/14-3-3ζ protein complex by FC-A was not influenced by the disease-associated and 4-hydroxytamoxifen resistant ERα-Y537S mutant. Together, these molecular and mechanistic insights provide direction for targeting ERα via the ERα/14-3-3 complex as an alternative drug discovery approach.</p

Rape, inequality and the criminal justice response in England: The importance of age and gender

© The Author(s) 2019. This article draws upon quantitative and content analysis of 585 reports of rape recorded within two police force areas in England in 2010 and in 2014 tracking individual incidents to eventual outcome to examine the impact, if any, of intersecting inequalities on trajectories of rape cases reported to police. The data were collected as part of the wider Economic and Social Research Council funded Justice, Inequality and Gender-Based Violence research project which examined victim-survivor experiences and perspectives on justice. Building on existing distinctions between types of rape case based on the relationship between victim-survivor and accused, the results suggest age and gender are significant factors in how sexual violence, and the criminal justice system, is experienced. While younger women and girls were disproportionately affected by certain types of sexual violence case and more likely to come into contact with the criminal justice system compared to men and older women, they were not necessarily more likely to achieve a conviction. The findings also confirm that some of the most vulnerable victims-survivors of sexual violence, especially those with poor mental health, are still not achieving criminal justice. Victims-survivors from Black and minority ethnic group or lesbian, gay, bisexual, transgender, transsexual, queer groups are underrepresented within the criminal justice system, implying these groups are not seeking a criminal justice response in the same way as ‘white’ heterosexual victims-survivors