State-of-the-art of spatial arch bridges

The paper describes a new form of bridge called a spatial arch bridge. This bridge type was developed in response to the demand for landmark structures, which have started to appear in the modern urban landscape to provide a symbol of originality, innovation and progress. Spatial arch bridges are defined as bridges in which the vertical deck loads produce bending moments and shear forces not contained in the arch plane, owing to their geometrical and structural configuration. Moreover, the arch itself may not be contained in a plane. The different variables and geometries that create such a structural configuration have been studied and classified. A wide compilation of examples of this bridge type has been made in chronological order, according to their construction date, from Maillarts first concrete spatial arch bridges to the latest designs and materials

Reversal of diastereoselectivity in the synthesis of Peptidomimetic 3‑Carboxamide-1,4-benzodiazepin-5-ones

Enantiopure 3-carboxamide-1,4-benzodiazepin-5-ones were synthesized via the Ugi reaction followed by the Staudinger/aza-Wittig or reduction reactions in only two steps. A complete reversal of diastereoselectivity was achieved depending on the cyclization methodology employed. The different orientation of the C3 substituent in our 3-substituted 1,4-benzodiazepin-5-ones with respect to the most studied 1,4-benzodiazepin-2-ones makes them complementary in the development of new drugs because the primary source of binding selectivity of 1,4-benzodiazepines is the selective recognition of ligand conformations by the receptor.Ministerio de Economía y Competitividad, Spain (Project CTQ2012-31611), Junta de Castilla y León, Consejería de Educación y Cultura y Fondo Social Europeo (Project BU246A12-1) and the European Commission, Seventh Framework Programme (Project SNIFFER FP7-SEC-2012-312411)

A sala de ensaio : o espa?o informe do ator na cria??o teatral.

Programa de P?s-Gradua??o em Artes C?nicas. Instituto de Filosofia, Artes e Cultura, Universidade Federal de Ouro Preto.Esta disserta??o discorre sobre o processo Corpoal?ngua, vivido junto ao N3PS (N?mades permanentes pesquisam e perfomam), onde observo a pr?tica que realizamos do Teatro Desess?ncia de Clarissa Alcantara, em di?logo com os pensamentos de Antanin Artaud, Guilles Deleuze, F?lix Guattari e Cassiano Quilici a cerca do corpo sem ?rg?os. Esta sala de ensaio como processo se abre para pensarmos, arte e vida, ator e homem cotidiano n?o mais como lugares determinados, mas como multiplicidades e atravessamentos. A ruptura do que ? posto como molde sobre os corpos ? capaz de nos colocar em constante movimento de reinven??o, operando revolu??es.The present dissertation discusses issues related to Corpoal?ngua, experimented by N3Ps (N?mades permanentes pesquisam e perfomam), where is observed the practice of Clarissa Alcantara's Teatro Desess?ncia, in dialogue with the thoughts of Antanin Artaud, Guilles Deleuze, F?lix Guattari and Cassiano Quilici on the ?body without organs?. This rehearsal room as a process pavement the way for thinking art and life, actor and the everyday man no longer as static places but as multiplicities and ?atravessamentos?. The rupture from what is imposed as mold for the bodies can set us in a constant movement of reinvention, operating revolutions

Nanopatterned UV curable hydrogels for biomedical applications

With an increasing use of emerging patterning technologies such as UV-NIL in biotechnological applications there is at the same time a raising demand for new material for such applications. Here we present a PEG based precursor mixed with a photoinitiator to make it UV sensitive as a new material aimed at biotechnological applications. Using HSQ patterned quartz stamps we observed excellent pattern replication indicating good flow properties of the resist. We were able to obtain imprints with <20 nm residual layer. The PEG based resist has hydrogel properties and it swelling in water was observed by AFM