Good Governance: developing effective board-management relations in public and voluntary organizations

The research suggests that boards do make a number of important contributions to the organisations they serve. The nature of these contributions caries and is influenced by a variety of factors: for example the way the organisation is regulated; the history and culture of the organisation; the way board members are chosen; board member's skills and experience; the relationship with senior managers; and the way the governance function is managed

Colour normalisation to reduce inter-patient and intra-patient variability in microaneurysm detection in colour retinal images

Images of the human retina vary considerably in their appearance depending on the skin pigmentation (amount of melanin) of the subject. Some form of normalisation of colour in retinal images is required for automated analysis of images if good sensitivity and specificity at detecting lesions is to be achieved in populations involving diverse races. Here we describe an approach to colour normalisation by shade-correction intra-image and histogram normalisation inter-image. The colour normalisation is assessed by its effect on the automated detection of microaneurysms in retinal images. It is shown that the Na¨ıve Bayes classifier used in microaneurysm detection benefits from the use of features measured over colour normalised images

Synergy and Group Size in Microbial Cooperation

Microbes produce many molecules that are important for their growth and development, and the consumption of these secretions by nonproducers has recently become an important paradigm in microbial social evolution. Though the production of these public goods molecules has been studied intensely, little is known of how the benefits accrued and costs incurred depend on the quantity of public good molecules produced. We focus here on the relationship between the shape of the benefit curve and cellular density with a model assuming three types of benefit functions: diminishing, accelerating, and sigmoidal (accelerating then diminishing). We classify the latter two as being synergistic and argue that sigmoidal curves are common in microbial systems. Synergistic benefit curves interact with group sizes to give very different expected evolutionary dynamics. In particular, we show that whether or not and to what extent microbes evolve to produce public goods depends strongly on group size. We show that synergy can create an “evolutionary trap” which can stymie the establishment and maintenance of cooperation. By allowing density dependent regulation of production (quorum sensing), we show how this trap may be avoided. We discuss the implications of our results for experimental design

Children with neonatal Hypoxic Ischemic Encephalopathy (HIE) treated with therapeutic hypothermia are not as school ready as their peers

Aim: We aimed to determine whether children with neonatal hypoxic-ischaemic encephalopathy (HIE) treated with therapeutic hypothermia (TH) differ from their peers on measures of fine motor skills, executive function, language and general cognitive abilities; factors that are important for school readiness. Methods: We compared school readiness in 31children with HIE treated with TH (without Cerebral Palsy; mean age 5 years 4 months) with 20 typically developing children without HIE (mean age 5 years 6 months). Results: Children with HIE scored significantly lower than typically developing children on fine motor skills, executive functions, memory and language. Conclusion: While general cognitive abilities and attainment were in the normal range, our findings suggest those scores mask specific underlying difficulties identified by more focussed assessments. Children with HIE treated with TH may not be as “school ready” as their typically developing classmates and may benefit from long-term follow-up until starting school

Comparison of various methods to delineate blood vessels in retinal images

The blood vessels in the human retina are easily visualisable via digital fundus photography and provide an excellent window to the health of a patient affected by diseases of blood circulation such as diabetes. Diabetic retinopathy is identifiable through lesions of the vessels such as narrowing of the arteriole walls, beading of venules into sausage like structures and new vessel growth as an attempt to reperfuse ischaemic regions. Automated quantification of these lesions would be beneficial to diabetes research and to clinical practice, particularly for eye-screening programmes for the detection of eye-disease amongst diabetic persons

Development of retinal blood vessel segmentation methodology using wavelet transforms for assessment of diabetic retinopathy

Automated image processing has the potential to assist in the early detection of diabetes, by detecting changes in blood vessel diameter and patterns in the retina. This paper describes the development of segmentation methodology in the processing of retinal blood vessel images obtained using non-mydriatic colour photography. The methods used include wavelet analysis, supervised classifier probabilities and adaptive threshold procedures, as well as morphology-based techniques. We show highly accurate identification of blood vessels for the purpose of studying changes in the vessel network that can be utilized for detecting blood vessel diameter changes associated with the pathophysiology of diabetes. In conjunction with suitable feature extraction and automated classification methods, our segmentation method could form the basis of a quick and accurate test for diabetic retinopathy, which would have huge benefits in terms of improved access to screening people for risk or presence of diabetes

Development of an Integrated Governance Strategy for the Voluntary and Community Sector

This report on governance provides a framework for thinking about how policy makers, funders,regulators and advisers can all work with Board members and staff to enhance the effectiveness of nonprofit organisations. It was commissioned by the Active Community Unit (ACU) of the Home Office, in parallel with other reviews designed to improve the capacity of the voluntary and community sector, at a time when the sector plays an increasingly important role in the delivery of services using public funds. That role has recently been investigated in two Government reports, the Cross Cutting Review carried out by the Treasury, and the Strategy Unit review of charities and nonprofits. Our report proposes actions of three types: some that can be taken immediately, some that require further discussion with key interests, and some integration with the other ACU reviews. Taken together they provide the starting point for an evolving strategy to improve governance across the sector. We recommend ACU chairs a group charged with the responsibility for planning and implementing this. Our focus is on governance as 'the systems and processes concerned with ensuring the overall direction, supervision and accountability of an organisation'. This is often taken to mean the way that a Board, management committee or other governing body steers the overall development of an organisation, where day-to-day management is in the hands of staff or volunteers. Sometimes, of course, the committee and volunteers are the same. They – like all governing bodies – have to balance the interests of the organisation and those they are trying to serve, while being conscious of financial and legal responsibilities, and the requirements of funders and other supporters

The integrated database for African policymakers

The Integrated Database for African Policymakers (IDAPs; http://www.walker.ac.uk/projects/idaps-integrated-database-for-african-policy-makers/), is a technological initiative to intended to provide valuable insight and quantitative evidence to policy makers, planners and doers, at international, national and local levels to inform scenario planning and support investment interventions for early action and adaptation. It also provides a rich source of data for researchers exploring the impacts of climate change in rural African communities, and potentially beyond. IDAPS is jointly led by the Walker Institute and Evidence for Development, our embedded NGO partner

Exploring the Design of mHealth Systems for Health Behavior Change using Mobile Biosensors

A person’s health behavior plays a vital role in mitigating their risk of disease and promoting positive health outcomes. In recent years, mHealth systems have emerged to offer novel approaches for encouraging and supporting users in changing their health behavior. Mobile biosensors represent a promising technology in this regard; that is, sensors that collect physiological data (e.g., heart rate, respiration, skin conductance) that individuals wear, carry, or access during their normal daily activities. mHealth system designers have started to use the health information from physiological data to deliver behavior-change interventions. However, little research provides guidance about how one can design mHealth systems to use mobile biosensors for health behavior change. In order to address this research gap, we conducted an exploratory study. Following a hybrid approach that combines deductive and inductive reasoning, we integrated a body of fragmented literature and conducted 30 semi-structured interviews with mHealth stakeholders. From this study, we developed a theoretical framework and six general design guidelines that shed light on the theoretical pathways for how the mHealth interface can facilitate behavior change and provide practical design considerations