Is It Possible to Have Cheaper Drugs and Preserve the Incentive to Innovate: Reforming the Drug Approval Process According to Market Principles

This paper argues that drugs are expensive not because of a lack of competition among research-based pharmaceutical companies, but because of a lack of competition in the drug approval process. Lack of competition in the drug approval process has led to exceedingly high drug development costs. High drug development costs combined with artificially low drug prices, obtained through price control legislation and legislation that eases the entry of generic products into the market, has caused lower levels of pharmaceutical research and development, innovation, and economic growth.Privatization, Competition, Monopoly, Innovation, Drugs, Generics, Pharmaceuticals

Effect of surface finishing such as sand-blasting and CrAlN hard coatings on the cutting edge’s peeling tools’ wear resistance

The authors would like to thank IonBond (Chassieu-France) who made the sand-blasting treatments and the Regional Council of Burgundy and CTBA (Wood and Furniture Technical Centre) for their financial support.The aim of this study is first to define the effect of a surface finishing such as sand-blasting on the geometry of a wood cutting tool and its wear resistance. In addition, the effectiveness of surface coatings like CrAlN deposited by physical vapor deposition (PVD) technique on conventional and sand-blasted cutting edges was studied. A reference tool and different sand-blasted ones were tested by micro-peeling of beech in a laboratory. Microscopic observations, cutting forces measurement and cutting wear tests were carried out to quantify the behavior of these tools. The results obtained showed that the artificial wear by sandblasting leads to an increase in the wear resistance and coating effectiveness, and completely changes the type of damage done to the tools. The sand-blasting application combined or not with CrAlN coating showed an improvement in the wear resistance of the tools and a modification of the forces during the peeling process. The effectiveness of the CrAlN layers was improved thanks to the sand-blasting treatment and then the duplex ones performed better.Regional Council of Burgundy CTBA (Wood and Furniture Technical Centre

Motor imagery training improves precision of an upper limb movement in patients with hemiparesis

BACKGROUND: In healthy participants, beneficial effects of motor imagery training on movement execution have been shown for precision, strength, and speed. In the clinical context, it is still debated whether motor imagery provides an effective rehabilitation technique in patients with motor deficits.OBJECTIVE: To compare the effectiveness of two different types of movement training: motor imagery vs. motor execution.METHODS: Twenty-five patients with hemiparesis were assigned to one of two training groups: the imagery or the execution-training group. Both groups completed a baseline test before they received six training sessions, each of which was followed by a test session. Using a novel and precisely quantifiable test, we assessed how accurately patients performed an upper limb movement. RESULTS: Both training groups improved performance over the six test sessions but the improvement was significantly larger in the imagery group. That is, the imagery group was able to perform more precise movements than the execution group after the sixth training session while there was no difference at the beginning of the training.CONCLUSIONS: The results provide evidence for the benefit of motor imagery training in patients with hemiparesis and thus suggest the integration of cognitive training in conventional physiotherapy practice

Application of CrAlN coatings on carbide substrates in routing of MDF

This study deals with the development of Chromium Aluminium Nitride (CrAlN) hard coatings (by varying the nitrogen content in the plasma, the target bias voltage, the working pressure and the deposition time) and their characterization by physical and mechanical techniques (XRD, nanoindentation, Young’s modulus, stress, scratch-test, composition, etc.) in order to determine the optimal deposition conditions to apply the coatings to carbide substrates. Moreover, in order to improve the adhesion of the same optimal hard coatings and as it was efficient with Diamond Like Carbon (DLC) coatings, we tried to modify the carbide inserts by chemical attacks with Murakami’s agent before machining. The coated tools (with and without Murakami’s attack) were then tested in routing of Medium Density Fibreboard (MDF). A comparison of the abrasion and shock resistance of the conventional tools with the treated ones, was made. The efficiency of Murakami’s agent was also studied. It was obvious that the coated carbide tools had greater tool life than the untreated ones. Besides, Murakami’s attack was not optimized or not a solution to improve the adhesion of nitride coatings on carbide inserts.Regional Council of Burgundy ISOROY Franc

A New Division Algebra Representation of E7E_7

We decompose the Lie algebra $\mathfrak{e}_{8(-24)}$ into representations of $\mathfrak{e}_{7(-25)}\oplus\mathfrak{sl}(2,\mathbb{R})$ using our recent description of $\mathfrak{e}_8$ in terms of (generalized) $3\times3$ matrices over pairs of division algebras. Freudenthal's description of both $\mathfrak{e}_7$ and its minimal representation are therefore realized explicitly within $\mathfrak{e}_8$, with the action given by the (generalized) matrix commutator in $\mathfrak{e}_8$, and with a natural parameterization using division algebras. Along the way, we show how to implement standard operations on the Albert algebra such as trace of the Jordan product, the Freudenthal product, and the determinant, all using commutators in $\mathfrak{e}_8$.Comment: 11 page