The Metabolism of an Exogenous Lipid Source during Septic Shock in the Puppy

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142302/1/jpen0652.pd

Magnetic resonance imaging assessment of lipomatous soft-tissue tumors

Aim: To establish the accuracy of magnetic resonance imaging (MRI) in distinguishing between benign and malignant lipomatous tumors; to evaluate the reproducibility of the MRI interpretation assessing the agreement between judgments of two radiologists with the same experience in soft-tissue sarcomas; to identify an association among MRI findings (size, depth, septa, nodules, signal homogeneity) and nature of the lesion. Materials and Methods: A total of 54 patients (28 men and 26 women), with a mean age of 56 (range=27-84) were included years. All subjects followed-up by the Multidisciplinary Sarcoma Group. The following MRI findings were judged in a blind study by two radiologists: Size, localization, septa, nodules and signal homogeneity. A diagnostic indication was then given from among lipoma, atypical lipomatous tumour (ALT) and liposarcoma. Accuracy in distinguishing between benign and malignant lesions, and between lipoma and ALT (Fisher's exact test), inter-operator agreement (Cohen's kappa), association of MRI findings and malignancy of the lesion (Fisher's exact test and odds ratio) were evaluated. Results: The inter-operator agreement was complete (100%). The agreement between diagnostic hypothesis and histological diagnosis was statistically significant (p<0.05). Among the radiological findings taken into account, only septa and signal homogeneity were significantly associated with the malignancy of the lesion (p<0.05). Conclusion: MRI could be helpful in distinguishing lipomatous tumors, allowing biopsy to be avoided in some cases (negative predictive value=100%)

Decomposition channels alternative to remote-charge fragmentations observed in mass spectrometry of alkyltrimethylammonium cations

A series of alkyltrimethylammonium cations, generated by fast atom bombardment from 1-dodecanaminium-, 1-tetradecanaminium- and 1-hexadecanaminium-N,N,N-trimethyl bromides, were studied by high-energy collisions and comparison with N,N,N-trimethyl-d(9) labelled analogues, The results show that, together with remote-charge fragmentation processes, alkyltrimethylammonium cations exhibit further decomposition pathways which may be explained by interaction between the alkyl chain and the methyl group linked to the nitrogen atom, The sharp interruption of remote-charge fragmentation at the C-5 atom was observed for all compounds and explained as due to the formation of an energetically favoured six-membered cyclic structure