Papal Sin: Structures Of Deceit, by Gary Wills

Book review by David L. Coppola. Wills, Garry. Papal Sin: Structures of Deceit. New York: Doubleday, 2000

Creating Space for Dialogue

Judaism, Christianity and Islam teach that it is God’s will that all people live in peace with each other. Peace will be adequately advanced only when religious people and religious institutions are integral to the processes of social justice in every part of the globe. It is religion that can help to reach into the depths of humanity’s struggles and the heights of human accomplishments to salve such injuries. Unfortunately, dialogue for the sake of building mutual respect, understanding and ultimately, peaceful coexistence seems more difficult than ever, in part due to the resistance and obstruction by some who claim to be faithful religious adherents

The Problem of Religion, Violence, and Peace: An Uneasy Trilogy

Drawing primarily on Jewish, Christian, and Islamic texts, as well as on philosophical and sociological concepts, I will examine religion and its relationship to violence from three distinct, but related perspectives; namely, that 1) religion is directly linked with violence; 2) religion functions as one among many factors that influence violence; and 3) religions are unwilling participants in the practice of violence. This essay begins by setting a context for the study of religion, violence, and peace, followed by a presentation of the three perspectives mentioned above, concluding with possibilities for the study and practice of future peace-making

What Do We Want the Other to Teach About Us?

Based on five conferences, \u27What Do We Want the Other to Teach About Us, held in Jerusalem (2000) on theological traditions; in Edmonton, Canada (2000) on historical traditions; in Rome, Italy (2001) on prayer and liturgy; in Bamberg, Germany (2002) on historical traditions; and in Fairfield, Connecticut (2003) on ethical traditions, and sponsored by the Center for Christian-Jewish Understanding of Sacred Heart University, Fairfield, Connecticut, in collaboration with the Elijah Interfaith Institute, Jerusalem; the Edmonton Interfaith Centre for Education and Action, Canada; the University of Bamberg, Germany; and Sacred Heart University.https://digitalcommons.sacredheart.edu/shupress_bks/1008/thumbnail.jp

Religion, Violence and Peace: Continuing Conversations and Study Guide

Continuing the conversation that began with the 1999 volume, Religion and Violence, Religion and Peace, this thought-provoking collection of essays also offers a Study Guide that explores the questions of violence and peace faced by people of the Abrahamic faiths. The essays in this work were presented by Jewish, Christian and Muslim leaders and scholars at the 2003 conference, “Pathways to Peace in the Abrahamic Faiths,” sponsored by the Center for Christian-Jewish Understanding of Sacred Heart University in Fairfield, Connecticut. Contributors include David L. Coppola, Rabbi Rene-Samuel Sirat, Adolphe Steg, Rabbi Rene Gutman, James G. Williams, Jean Dujardin, Azizah Al-Hibri, and Louay M. Safi.https://digitalcommons.sacredheart.edu/shupress_bks/1009/thumbnail.jp

Plasma methionine sulfoxide in persons with familial Alzheimer’s disease mutations

The final, published version of this article is available at http://www.karger.com/?doi=10.1159/000338546.BACKGROUND: Convergent evidence suggests that oxidative stress plays a central role in the pathology of Alzheimer’s disease (AD). We asked if consequently, oxidation of methionine residues to methionine sulfoxide (MetO) increased in plasma proteins of persons carrying familial AD (FAD) mutations. METHODS: Plasma was collected from 31 persons from families harboring PSEN1 or APP mutations. Using Western blot analysis with a novel anti-MetO polyclonal antibody, MetO levels were measured and compared between FAD mutation carriers (MCs) and non-mutation carrying (NCs) kin. RESULTS: A MetO-positive 120 kDa gel band distinguished FAD MCs and NCs (mean 11.4 ± 2.8 vs. 4.0 ± 3.1, p = 0.02). In a subset of subjects for whom both measurements were available, MetO levels correlated well with plasma F2-isoprostane (r = 0.81, p < 0.001) and superoxide dismutase 1 (r = 0.52, p = 0.004) levels. CONCLUSIONS: Our data provide evidence for elevated MetO levels in persons carrying FAD mutations that correlate with other indices of oxidative stress and suggest that plasma oxidative stress markers may be useful for diagnosis of AD

Intermolecular 1,3-dipolar cycloadditions of muchnones with acetylenic dipolarophiles: Sorting out the regioselectivity

A series of 1,3-dipolar cycloadditions of munchnones with acetylenic dipolarophiles was studied, wherein factors related to regioselectivity were investigated. The results from munchnones with electronically divergent thioaryl substituents compared with others bearing alkyl substituents suggest that an unsymmetrical transition state structure, rather than FMO perturbation, plays a significant role in regioselection. If eclipsing interactions preclude a highly unsymmetrical transition state however, then minimizing steric interactions becomes important. A pair of complementarily substituted munchnones, differing only in the position of isotopic labels, establishes an inherently symmetrical electronic nature of the mesoionic heterocycle.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31644/1/0000578.pd

Rare Copy Number Variants in \u3cem\u3eNRXN1\u3c/em\u3e and \u3cem\u3eCNTN6\u3c/em\u3e Increase Risk for Tourette Syndrome

Tourette syndrome (TS) is a model neuropsychiatric disorder thought to arise from abnormal development and/or maintenance of cortico-striato-thalamo-cortical circuits. TS is highly heritable, but its underlying genetic causes are still elusive, and no genome-wide significant loci have been discovered to date. We analyzed a European ancestry sample of 2,434 TS cases and 4,093 ancestry-matched controls for rare (\u3c 1% frequency) copy-number variants (CNVs) using SNP microarray data. We observed an enrichment of global CNV burden that was prominent for large (\u3e 1 Mb), singleton events (OR = 2.28, 95% CI [1.39–3.79], p = 1.2 × 10−3) and known, pathogenic CNVs (OR = 3.03 [1.85–5.07], p = 1.5 × 10−5). We also identified two individual, genome-wide significant loci, each conferring a substantial increase in TS risk (NRXN1 deletions, OR = 20.3, 95% CI [2.6–156.2]; CNTN6 duplications, OR = 10.1, 95% CI [2.3–45.4]). Approximately 1% of TS cases carry one of these CNVs, indicating that rare structural variation contributes significantly to the genetic architecture of TS

Representation of precipitation and top-of-atmosphere radiation in a multi-model convection-permitting ensemble for the Lake Victoria Basin (East-Africa)

The CORDEX Flagship Pilot Study ELVIC (climate Extremes in the Lake VICtoria basin) was recently established to investigate how extreme weather events will evolve in this region of the world and to provide improved information for the climate impact community. Here we assess the added value of the convection-permitting scale simulations on the representation of moist convective systems over and around Lake Victoria. With this aim, 10 year present-day model simulations were carried out with five regional climate models at both PARameterized (PAR) scales (12–25 km) and Convection-Permitting (CP) scales (2.5–4.5 km), with COSMO-CLM, RegCM, AROME, WRF and UKMO. Most substantial systematic improvements were found in metrics related to deep convection. For example, the timing of the daily maximum in precipitation is systematically delayed in CP compared to PAR models, thereby improving the agreement with observations. The large overestimation in the total number of rainy events is alleviated in the CP models. Systematic improvements were found in the diurnal cycle in Top-Of-Atmosphere (TOA) radiation and in some metrics for precipitation intensity. No unanimous improvement nor deterioration was found in the representation of the spatial distribution of total rainfall and the seasonal cycle when going to the CP scale. Furthermore, some substantial biases in TOA upward radiative fluxes remain. Generally our analysis indicates that the representation of the convective systems is strongly improved in CP compared to PAR models, giving confidence that the models are valuable tools for studying how extreme precipitation events may evolve in the future in the Lake Victoria basin and its surroundings