Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages

Apicomplexan protozoan pathogens avoid destruction and establish a replicative niche within host cells by forming a nonfusogenic parasitophorous vacuole (PV). Here we present evidence for lysosome-mediated degradation of Toxoplasma gondii after invasion of macrophages activated in vivo. Pathogen elimination was dependent on the interferon γ inducible-p47 GTPase, IGTP, required PI3K activity, and was preceded by PV membrane indentation, vesiculation, disruption, and, surprisingly, stripping of the parasite plasma membrane. Denuded parasites were enveloped in autophagosome-like vacuoles, which ultimately fused with lysosomes. These observations outline a series of mechanisms used by effector cells to redirect the fate of a classically nonfusogenic intracellular pathogen toward a path of immune elimination

The economic importance of the Belgian ports: Flemish maritime ports, Liège port complex and the port of Brussels – Report 2016

This Working Paper analyses the economic importance of the Belgian ports based largely on the annual accounts data for the year 2016. As the years prior to 2016 have been described in earlier papers in the same series, we mainly focus on the figures for 2016 and developments between 2015 and 2016. On the back of strong growth, direct value added in the Belgian ports remained more or less stable in 2016 at around € 18 000 million (current prices) or roughly 4.3% of Belgium’s GDP. Direct value added declined in the Flemish seaports, mainly in the port of Antwerp. Ghent and Zeebrugge could only partly compensate for the fall in Antwerp’s value added, while Ostend showed a small decline itself. The inland ports as a whole grew over the period 2015-2016; the port of Brussels registered a decline and the Liège port complex an increase. Indirect value added is around 82% of the direct figure. After declining from 2012, direct employment in the Belgian ports was more or less stable in 2016 at around 115 000 FTE or approximately 2.8% of Belgium’s total domestic employment. Direct employment in the Flemish seaports increased, mainly in the ports of Zeebrugge, Ghent and Antwerp. Ostend showed a decline in employment. The inland ports recorded lower employment; the port of Brussels registered a decline, as did the Liège port complex. Indirect employment is around 1.2 times the direct figure. Delving deeper into the data and trying to explain the above trends in terms of the structural composition of the Belgian ports shows that all ports are concentrated on a few sectors, and within those sectors often on just a handful of companies. Based on the figures of the traffic, the Flemish ports can be considered as real bridgeheads for trade with the UK. Developments regarding the modalities and consequences of the Brexit therefor should be followed with the greatest attention. Given the existing import and export volumes in terms of tonnage, it seems it will mostly be a challenge in Zeebrugge and to some extent for Antwerp

Multidetector Computed Tomography Diagnosis of Gastric Volvulus through the Foramen of Morgagni

Morgagni hernia is considered to be the rarest form of all diaphragmatic hernias. It develops through a congenital defect in the retrosternal area. Usually asymptomatic, this entity can lead to life-threatening complications such as incarceration, strangulation or volvulus of the herniated viscus. We hereby report a rare case of organoaxial gastric volvulus producing through the foramen of Morgagni in a 78-year-old woman. The full diagnosis was made by upper gastro-intestinal series and multidetector computed tomography (MDCT). The basic anatomy, physiopathology, diagnostic methods, complications and surgical treatment of Morgagni hernia are briefly reviewed

Forward pi^0 Production and Associated Transverse Energy Flow in Deep-Inelastic Scattering at HERA

Deep-inelastic positron-proton interactions at low values of Bjorken-x down to x \approx 4.10^-5 which give rise to high transverse momentum pi^0 mesons are studied with the H1 experiment at HERA. The inclusive cross section for pi^0 mesons produced at small angles with respect to the proton remnant (the forward region) is presented as a function of the transverse momentum and energy of the pi^0 and of the four-momentum transfer Q^2 and Bjorken-x. Measurements are also presented of the transverse energy flow in events containing a forward pi^0 meson. Hadronic final state calculations based on QCD models implementing different parton evolution schemes are confronted with the data.Comment: 27 pages, 8 figures and 3 table

Inelastic photoproduction of J/Psi mesons at HERA

An analysis of inelastic photoproduction of J/Psi mesons is presented using data collected at the ep collider HERA corresponding to an integrated luminosity of above 80pb-1. Differential and double differential cross sections are measured in a wide kinematic region: 6