Public Relations Goal—Telling How Agricultural Progress Benefits All

It may be trite to list the production marvels in agriculture for the various publics with whom we work through universities, agri-business firms, government agencies, and the like

Investigations into the Sarcomeric Protein and Ca2+-Regulation Abnormalities Underlying Hypertrophic Cardiomyopathy in Cats (Felix catus).

Hypertrophic cardiomyopathy (HCM) is the most common single gene inherited cardiomyopathy. In cats (Felix catus) HCM is even more prevalent and affects 16% of the outbred population and up to 26% in pedigree breeds such as Maine Coon and Ragdoll. Homozygous MYBPC3 mutations have been identified in these breeds but the mutations in other cats are unknown. At the clinical and physiological level feline HCM is closely analogous to human HCM but little is known about the primary causative mechanism. Most identified HCM causing mutations are in the genes coding for proteins of the sarcomere. We therefore investigated contractile and regulatory proteins in left ventricular tissue from 25 cats, 18 diagnosed with HCM, including a Ragdoll cat with a homozygous MYBPC3 R820W, and 7 non-HCM cats in comparison with human HCM (from septal myectomy) and donor heart tissue. Myofibrillar protein expression was normal except that we observed 20–44% MyBP-C haploinsufficiency in 5 of the HCM cats. Troponin extracted from 8 HCM and 5 non-HCM cat hearts was incorporated into thin filaments and studied by in vitro motility assay. All HCM cat hearts had a higher (2.06 ± 0.13 fold) Ca2+-sensitivity than non-HCM cats and, in all the HCM cats, Ca2+-sensitivity was not modulated by troponin I phosphorylation. We were able to restore modulation of Ca2+-sensitivity by replacing troponin T with wild-type protein or by adding 100 μM Epigallocatechin 3-gallate (EGCG). These fundamental regulatory characteristics closely mimic those seen in human HCM indicating a common molecular mechanism that is independent of the causative mutation. Thus, the HCM cat is a potentially useful large animal model

Moving Five-Branes in Low-Energy Heterotic M-Theory

We construct cosmological solutions of four-dimensional effective heterotic M-theory with a moving five-brane and evolving dilaton and T modulus. It is shown that the five-brane generates a transition between two asymptotic rolling-radii solutions. Moreover, the five-brane motion always drives the solutions towards strong coupling asymptotically. We present an explicit example of a negative-time branch solution which ends in a brane collision accompanied by a small-instanton transition. The five-dimensional origin of some of our solutions is also discussed.Comment: 16 pages, Latex, 3 eps figure

Phase Equilibration and Magnetic Field Generation in U(1) Bubble Collisions

We present the results of lattice computations of collisions of two expanding bubbles of true vacuum in the Abelian Higgs model with a first-order phase transition. New time-dependent analytical solutions for the Abelian field strength and the phase of the complex field are derived from initial conditions inferred from linear superposition and are shown to be in excellent agreement with the numerical solutions especially for the case where the initial phase difference between the bubbles is small. With a step-function approximation for the initial phase of the complex field, solutions for the Abelian field strength and other gauge-invariant quantities are obtained in closed form. Possible extensions of the solution to the case of the electroweak phase transition and the generation of primordial magnetic fields are briefly discussed.Comment: LaTeX, 41 pages, 6 figures, submitted to Physical Review

N=1 Supergravity Chaotic Inflation in the Braneworld Scenario

We study a N=1 Supergravity chaotic inflationary model, in the context of the braneworld scenario. It is shown that successful inflation and reheating consistent with phenomenological constraints can be achieved via the new terms in the Friedmann equation arising from brane physics. Interestingly, the model satisfies observational bounds with sub-Planckian field values, implying that chaotic inflation on the brane is free from the well known difficulties associated with the presence of higher order non-renormalizable terms in the superpotential. A bound on the mass scale of the fifth dimension, M_5 \gsim 1.3 \times 10^{-6} M_P, is obtained from the requirement that the reheating temperature be higher than the temperature of the electroweak phase transition.Comment: 5 pages, 1 Table, Revtex

Renormalization Group Approach to Generalized Cosmological models

We revisit here the problem of generalized cosmology using renormalization group approach. A complete analysis of these cosmologies, where specific models appear as asymptotic fixed-points, is given here along with their linearized stability analysis.Comment: 10 pages, to appear in the International Journal of Theoretical Physic