5,392 research outputs found

    Tunable diode laser heterodyne radiometer measurement of atmospheric absorption of solar radiation

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    A tunable infrared heterodyne radiometer (TIHR) which uses a diode laser as the local oscillator is described as well as methods for the evaluation of the excess noise characteristics of the tunable diode laser. Preliminary atmospheric absorption data taken with the TIHR are presented and show the capability of the TIHR for making the highest resolution atmospheric measurements to date

    REGULATORY FUNCTIONS OF NOTCH SIGNALING IN EARLY EMBRYONIC VASCULAR DIFFERENTIATION AND VESSEL REMODELING

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    The signaling cascades that direct the morphological differentiation of the vascular system during early embryogenesis are not well defined. Several signaling pathways, including Notch and VEGF signaling, are critical for the formation of the vasculature in the mouse. However, the relationship between the molecular signals and transcriptional networks directing this process are still not well defined. To further understand the role of Notch signaling during endothelial differentiation and the genes regulated by this pathway, both loss-of-function and gain-of-function approaches were analyzed in vivo and in vitro. Conditional transgenic models were used to expand and ablate Notch signaling in the early embryonic endothelium. Embryos with activated Notch1 in the vasculature displayed a variety of defects, particularly in the yolk sac, and die soon after E10.5. These phenotypes were distinct from endothelial loss-of-function of Rbpj, a transcriptional regulator of Notch activity. Gene expression analysis of RNA isolated from the yolk sac of transgenic embryos indicated aberrant expression in a variety of genes in these models. In particular, a variety of secreted factors, including the VEGF family member, Pgf, displayed coordinate expression defects in the loss-of-function and gain-of-function models. These data indicate that Notch signaling may have potential nonautonomous roles in the remodeling of the yolk sac capillary plexus. To further understand the role of placental growth factor during endothelial differentiation, an in vivo gain-of-function transgenic model was developed. Embryos with expanded expression of Pgf in the vasculature display two distinct phenotypes, which were classified moderate and severe. Most notably, in both classes, the extraembryonic vasculature of the yolk sac displayed remodeling differentiation defects, with few matured vessels. Gene expression analysis of RNA isolated from the yolk sac of transgenic embryos indicated aberrant expression in a variety of genes. In particular, Notch family members showed increased expression in the gain-of-function model. The data from this model demonstrates regulatory connections between the VEGF and Notch signaling pathways during endothelial differentiation. We propose a role for Notch signaling in elaborating the microenvironment of the nascent arteriole, and suggest that novel regulatory connections exist between Notch signaling and other signaling pathways, particularly the VEGF family, during endothelial differentiation

    Use of LARS system for the quantitative determination of smoke plume lateral diffusion coefficients from ERTS images of Virginia

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    A technique for measuring smoke plume of large industrial sources observed by satellite using LARSYS is proposed. A Gaussian plume model is described, integrated in the vertical, and inverted to yield a form for the lateral diffusion coefficient, Ky. Given u, wind speed; y sub l, the horizontal distance of a line of constant brightness from the plume symmetry axis a distance x sub l, downstream from reference point at x=x sub 2, y=0, then K sub y = u ((y sub 1) to the 2nd power)/2 x sub 1 1n (x sub 2/x sub 1). The technique is applied to a plume from a power plant at Chester, Virginia, imaged August 31, 1973 by LANDSAT I. The plume bends slightly to the left 4.3 km from the source and estimates yield Ky of 28 sq m/sec near the source, and 19 sq m/sec beyond the bend. Maximum ground concentrations are estimated between 32 and 64 ug/cu m. Existing meteorological data would not explain such concentrations

    Cosmological Solution in M-theory on S^1/Z_2

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    We provide the first example of a cosmological solution of the Horava-Witten supergravity. This solution is obtained by exchanging the role of time with the radial coordinate of the transverse space to the five-brane soliton. On the boundary this corresponds to rotating an instanton solution into a tunneling process in a space with Lorentzian signature, leading to an expanding universe. Due to the freedom to choose different non-trivial Yang-Mills backgrounds on the boundaries, the two walls of the universe ( visible and hidden worlds) expand differently. However at late times the anisotropy is washed away by gravitational interactions.Comment: 10 pages, latex, no figur

    Expanded mixed multiscale finite element methods and their applications for flows in porous media

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    We develop a family of expanded mixed Multiscale Finite Element Methods (MsFEMs) and their hybridizations for second-order elliptic equations. This formulation expands the standard mixed Multiscale Finite Element formulation in the sense that four unknowns (hybrid formulation) are solved simultaneously: pressure, gradient of pressure, velocity and Lagrange multipliers. We use multiscale basis functions for the both velocity and gradient of pressure. In the expanded mixed MsFEM framework, we consider both cases of separable-scale and non-separable spatial scales. We specifically analyze the methods in three categories: periodic separable scales, GG- convergence separable scales, and continuum scales. When there is no scale separation, using some global information can improve accuracy for the expanded mixed MsFEMs. We present rigorous convergence analysis for expanded mixed MsFEMs. The analysis includes both conforming and nonconforming expanded mixed MsFEM. Numerical results are presented for various multiscale models and flows in porous media with shales to illustrate the efficiency of the expanded mixed MsFEMs.Comment: 33 page

    The string wave function across a Kasner singularity

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    A collision of orbifold planes in eleven dimensions has been proposed as an explanation of the hot big bang. When the two planes are close to each other, the winding membranes become the lightest modes of the theory, and can be effectively described in terms of fundamental strings in a ten dimensional background. Near the brane collision, the eleven-dimensional metric is an Euclidean space times a 1+1-dimensional Milne universe. However, one may expect small perturbations to lead into a more general Kasner background. In this paper we extend the previous classical analysis of winding membranes to Kasner backgrounds, and using the Hamiltonian equations, solve for the wave function of loops with circular symmetry. The evolution across the singularity is regular, and explained in terms of the excitement of higher oscillation modes. We also show there is finite particle production and unitarity is preserved.Comment: 28 pages, 10 figure

    Space time neural networks for tether operations in space

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    A space shuttle flight scheduled for 1992 will attempt to prove the feasibility of operating tethered payloads in earth orbit. due to the interaction between the Earth's magnetic field and current pulsing through the tether, the tethered system may exhibit a circular transverse oscillation referred to as the 'skiprope' phenomenon. Effective damping of skiprope motion depends on rapid and accurate detection of skiprope magnitude and phase. Because of non-linear dynamic coupling, the satellite attitude behavior has characteristic oscillations during the skiprope motion. Since the satellite attitude motion has many other perturbations, the relationship between the skiprope parameters and attitude time history is very involved and non-linear. We propose a Space-Time Neural Network implementation for filtering satellite rate gyro data to rapidly detect and predict skiprope magnitude and phase. Training and testing of the skiprope detection system will be performed using a validated Orbital Operations Simulator and Space-Time Neural Network software developed in the Software Technology Branch at NASA's Lyndon B. Johnson Space Center

    Learning characteristics of a space-time neural network as a tether skiprope observer

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    The Software Technology Laboratory at the Johnson Space Center is testing a Space Time Neural Network (STNN) for observing tether oscillations present during retrieval of a tethered satellite. Proper identification of tether oscillations, known as 'skiprope' motion, is vital to safe retrieval of the tethered satellite. Our studies indicate that STNN has certain learning characteristics that must be understood properly to utilize this type of neural network for the tethered satellite problem. We present our findings on the learning characteristics including a learning rate versus momentum performance table

    Ambient ammonia measurements using laser photo-acoustic spectroscopy

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    Ammonia concentrations reached minimal levels (approximately 0.1 ppb) in early winter, followed by a sudden later winter increase. A direct relationship between ambient ammonia levels and air temperature was inferred from the data (linear correlation coefficient r=0.53). Ammonia concentrations were determined to be directly related to the absolute humidity of the air (r=0.72); a weaker relationship between ammonia concentrations and relative humidity was discovered (r=0.37). The data also indicated that ammonia levels were generally higher within continental air masses than those of maritime origin. Soil parameters such as pH and moisture content were found to have a major bearing on the release of gaseous ammonia from soils in the region
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