Top Female Hospital Executives in Las Vegas, Nevada: An in Depth Case Study

This paper will review the findings of in depth interviews with the four top female executives for the acute care hospitals in Las Vegas, Nevada, with regards to the ‘Glass Ceiling’ phenomenon, stereotyping and gender role behaviors, and how these elements have affected their careers. Out of seventeen (17) local senior executive positions, women hold four of these positions, or twenty-three percent (23.5%), compared to six percent (6%) nationally. The healthcare system changes were also a consideration for theses female executives, and how these changes have influenced their careers

The sensational Katherine Cecil Thurston : an investigation into the life and publishing history of a 'New Woman' author

This thesis investigates the publishing history of a significant New Woman author of the Edwardian period, Katherine Cecil Thurston (1875-1911). Until now Thurston's literary career has been the subject of little academic investigation. It is the aim of this thesis to contextualise her life and work within that of a New Woman writer and explore her relationship with those involved in the publishing process. By examining the narrative of Thurston's work and her interaction with Edwardian society we see how such New Woman authors contributed to the development of women's writing. The focal argument of the thesis is that Thurston used her femininity to generate an audience of female readers while at the same time creating alternate visions for women's lives, thus championing the cause of feminism. Thurston challenges many of the traditional, established views of the late Victorian period; however she was keenly aware of the need to operate within the bounds of traditional gender roles in order to ensure the publication of her work and the support of her conservative readership. Through her relationships with her publishers and readers we see how the opening decade of the twentieth century was fraught with unease and doubt about women's role within it. This thesis builds on recent studies by feminist critics in terms of rehabilitating women writers who have been omitted or lost from literary and publishing history. This research adds another author to that body of work and broadens our level of understanding of the position of woman authors of the period. By establishing the details of Thurston's life and work, this thesis aims to open new channels of investigation and as such amounts to a significant contribution to our awareness and understanding of New Women authors.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

The Sensational Katherine Cecil Thurston: An investigation into the life and publishing history of a ‘New Woman’ author

This thesis investigates the publishing history of a significant New Woman author of the Edwardian period, Katherine Cecil Thurston (1875-1911). Until now Thurston’s literary career has been the subject of little academic investigation. It is the aim of this thesis to contextualise her life and work within that of a New Woman writer and explore her relationship with those involved in the publishing process. By examining the narrative of Thurston’s work and her interaction with Edwardian society we see how such New Woman authors contributed to the development of women’s writing. The focal argument of the thesis is that Thurston used her femininity to generate an audience of female readers while at the same time creating alternate visions for women’s lives, thus championing the cause of feminism. Thurston challenges many of the traditional, established views of the late Victorian period; however she was keenly aware of the need to operate within the bounds of traditional gender roles in order to ensure the publication of her work and the support of her conservative readership. Through her relationships with her publishers and readers we see how the opening decade of the twentieth century was fraught with unease and doubt about women’s role within it. This thesis builds on recent studies by feminist critics in terms of rehabilitating women writers who have been omitted or lost from literary and publishing history. This research adds another author to that body of work and broadens our level of understanding of the position of woman authors of the period. By establishing the details of Thurston’s life and work, this thesis aims to open new channels of investigation and as such amounts to a significant contribution to our awareness and understanding of New Women authors

New synthetic cannabinoids and the potential for cardiac arrhythmia risk

Synthetic cannabinoid receptor agonists (SCRAs) have been associated with QT interval prolongation. Limited preclinical information on SCRA effects on cardiac electrogenesis results from the rapid emergence of new compounds and restricted research availability. We used two machine-learning-based tools to evaluate seven novel SCRAs' interaction potential with the hERG potassium channel, an important drug antitarget. Five SCRAs were predicted to have the ability to block the hERG channel by both prediction tools; ADB-FUBIATA was predicted to be a strong hERG blocker. ADB-5Br-INACA and ADB-4en-PINACA showed varied predictions. These findings highlight potentially proarrhythmic hERG block by novel SCRAs, necessitating detailed safety evaluations

Highlighting the hidden dangers of a ‘weak’ opioid:Deaths following use of dihydrocodeine in England (2001–2020)

BackgroundDihydrocodeine (DHC) is considered a ‘weak’ opioid, but there is evidence of its increasing misuse in overdose deaths. This research aims to analyse trends in DHC-related deaths in England relevant to source and dose of DHC, and decedent demographics.MethodsCases from England reported to the National Programme on Substance Abuse Deaths (NPSAD) where DHC was identified at post-mortem and/or implicated in death between 2001 and 2020 were extracted for analysis.Results2071 DHC-related deaths were identified. The greatest number of deaths involved illicitly obtained DHC and a significant increase in these deaths was recorded over time (r = 0.5, p = 0.03). However, there was a concurrent decline in the implication rate of DHC in causing death (r = −0.6, p &lt; 0.01). Fatalities were primarily due to accidental overdose (64.8%) and misuse was highly prevalent in combination with additional central nervous system depressants (95.3%), namely illicit heroin/morphine and diazepam. In contrast, when DHC was obtained over-the-counter (OTC) suicide mortality accounted for almost half of the deaths (42.5%). Differences in polysubstance use were also identified, with less heroin/morphine and benzodiazepine co-detection, but increased OTC codeine co-detection.ConclusionsDHC misuse in England is increasing. The pharmacological consideration of DHC as a ‘weak’ opioid may be misinterpreted by users, leading to accidental overdosing. There is an urgent need to understand increasing polypharmacy in overdose deaths. Additionally, suicides involving DHC is a potential cause for concern and a review of OTC opioid-paracetamol preparations is necessary to determine whether the benefits of these medications continue to outweigh the risks of intentional overdose.</p

Recreational ketamine-related deaths notified to the National Programme on Substance Abuse Deaths, England, 1997-2019

© 2021 The Authors. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).Background: Ketamine is a phencyclidine derivative with dissociative anaesthetic properties. Increasing numbers of individuals in England take ketamine recreationally. Information on deaths arising from such use in England is presented. Methods: Cases were extracted on 31 January 2020 from the National Programme on Substance Abuse Deaths database, based on text searches of the cause of death, coroner’s verdict and positive toxicology results for the terms ‘ketamine’ or ‘norketamine’. Findings: During 1997–2005, there were <5 deaths p.a. in which ketamine was implicated. Numbers increased until 2009 (21), plateauing until 2016; thereafter, deaths have risen to about 30 p.a. Decedents’ characteristics (N = 283): male 84.1%, mean age 31.2 (SD 10.0) years, employed 56.5%, drug use history 79.6% and living with others 60.3%. Ketamine was detected with other substances in most cases. Main (74.6%) underlying cause of death was accidental poisoning. Ketamine may have impaired judgement in other cases. Conclusions: Although controlled, recreational ketamine use and related fatalities continue to increase. Consumers need to be more aware of the potentially fatal risks they face.Peer reviewedFinal Published versio