Passive scalar mixing downstream of a synthetic jet in crossflow

An experimental investigation on passive scalar mixing due to the interaction of a synthetic jet with a thermal boundary layer is presented. From velocity measurements, performed by particle image velocimetry, two jet behaviours were identified. For jet to crossflow velocity ratios less than 1.2, the velocity fluctuations due to the jet/crossflow interaction stayed close to the wall. At higher ratios, the fluctuations moved away from the wall. The thermal mixing was examined using laser induced fluorescence. During expulsion, the thickness of the downstream thermal boundary layer increased whilst the thermal boundary layer was annihilated immediately downstream of the jet during entrainment

Ambidexterity of design management in different approaches to digital design:review of organizational attitudes in the East and the West in new product development process

Currently, there is growing interest in shaping a digital ecosystem that embraces holistic design approaches. In the digital realm, organizational approaches to managing design are required to shift to ‘designing’ towards holistic digital design, rather than ‘design’ for a completed output. Within this context, this paper reviews how organizational cultures can impact the development of holistic product design in competitive digital landscapes. This is done by investigating different organizational cultures as reflected in large Eastern and Western organizations’ approaches to managing design in the new product development (NPD) process. Despite significances of ‘designing’ this study discovered ambidexterity aspects of digital design in NPD projects, from international organizational perspectives. The findings offer key understandings that can explain the dilemmatic relations by examining key differences of design priorities in new digital product development in the East and the West: namely the East focusing on ‘design output’; whereas the West expecting ‘design outcomes’. Based on this we propose two major scenarios that represent the different approaches to managing design by organizational cultures

Magdalene Odundo

This book provides a complete illustrated catalogue of the artist's work to date (2004). There are essays by Emmanuel Cooper and Simon Olding, and a foreword by Sir Christopher Frayling. There are full-page colour reproductions of key works

Enhancement of thrust reverser cascade performance using aerodynamic and structural integration

This paper focuses on the design of a cascade within a cold stream thrust reverser during the early, conceptual stage of the product development process. A reliable procedure is developed for the exchange of geometric and load data between a two dimensional aerodynamic model and a three dimensional structural model. Aerodynamic and structural simulations are carried out using realistic operating conditions, for three different design configurations with a view to minimising weight for equivalent or improved aerodynamic and structural performance. For normal operational conditions the simulations show that total reverse thrust is unaffected when the performance of the deformed vanes is compared to the un-deformed case. This shows that for the conditions tested, the minimal deformation of the cascade vanes has no significant affect on aerodynamic efficiency and that there is scope for reducing the weight of the cascade. The pressure distribution through a two dimensional thrust reverser section is determined for two additional cascade vane configurations and it is shown that with a small decrease in total reverse thrust, it is possible to reduce weight and eliminate supersonic flow regimes through the nacelle section. By increasing vane sections in high pressure areas and decreasing sections in low pressure areas the structural performance of the cascade vanes in the weight reduced designs, is improved with significantly reduced levels of vane displacement and stress

Do age-associated changes of voltage-gated sodium channel isoforms expressed in the mammalian heart predispose the elderly to atrial fibrillation?

© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide. The prevalence of the disease increases with age, strongly implying an age-related process underlying the pathology. At a time when people are living longer than ever before, an exponential increase in disease prevalence is predicted worldwide. Hence unraveling the underlying mechanics of the disease is paramount for the development of innovative treatment and prevention strategies. The role of voltage-gated sodium channels is fundamental in cardiac electrophysiology and may provide novel insights into the arrhythmogenesis of AF. Nav1.5 is the predominant cardiac isoform, responsible for the action potential upstroke. Recent studies have demonstrated that Nav1.8 (an isoform predominantly expressed within the peripheral nervous system) is responsible for cellular arrhythmogenesis through the enhancement of pro-arrhythmogenic currents. Animal studies have shown a decline in Nav1.5 leading to a diminished action potential upstroke during phase 0. Furthermore, the study of human tissue demonstrates an inverse expression of sodium channel isoforms; reduction of Nav1.5 and increase of Nav1.8 in both heart failure and ventricular hypertrophy. This strongly suggests that the expression of voltage-gated sodium channels play a crucial role in the development of arrhythmias in the diseased heart. Targeting aberrant sodium currents has led to novel therapeutic approaches in tackling AF and continues to be an area of emerging research. This review will explore how voltage-gated sodium channels may predispose the elderly heart to AF through the examination of laboratory and clinical based evidence

Ceramics today

This article is a review related to Magdalene Odundo's research entitled Time and Again. This item appeared in The Art Workers Guild: proceedings and notes number 19 March 2005

The Ten Principles of Socially Responsible Digital Health Design

We are now, more than ever, aware of the social challenges that face us globally, keeping healthy is at the top of the list. Increasingly in the last ten years, designers have turned their attention not just to designing to alleviate and prevent illness but designing specifically to increase individual and community wellness and health. Digital health design has been one of those dimensions adopted to address the challenge. In this opinion piece we posit that in the domain of digital health all design should be socially responsible in order for us to consider it good design. Drawing on the history of socially responsible design and the emergence of digital health applications we propose Ten Principles of Socially Responsible Digital Health Design

Digital design in an international ecosystem:different approaches to managing design in the East and West

The role of design in the new product development (NPD) process is becoming increasingly complicated due to the complex digital landscape where multiple participants are globally involved in ‘designing’. It requires an understanding of different design approaches to digital product development in international organizational cultures. However, in design studies there has been little discussion concerning the relationship between organizational cultures and new digital product development from an international perspective. This paper proposes two design paradigms in the design management of new digital product development: the ‘design of management ’vs. the ‘management of design’ from cross-cultural perspectives -the East vs. the West. It provides insights by looking at large Eastern and Western global companies positioned in the digital industry, and by discussing the findings from interviews with experts in NPD projects. This paper provides the reader an understanding of how organizational approaches to digital product design differ between international NPD projects run by global large organizations in the East and the West

Plasticulture banana pepper response to clomazone applied pretransplanting

Few published studies exist documenting banana pepper tolerance to clomazone. Therefore, field trials were conducted in 2022 at two Indiana locations [Meigs Horticulture Research Farm and the Pinney Purdue Agricultural Center (PPAC)] to evaluate crop safety in plasticulture-grown banana pepper. The experimental design was a split-plot in which the main plot factor was the clomazone rate (0, 840, and 1,680 g ai ha–1) and the subplot factor was cultivar (‘Pageant’ and ‘Sweet Sunset’). Clomazone was applied over the top of black polyethylene mulch-covered raised beds and their respective bare-ground row middles 1 d prior to transplanting 12 pepper plants per subplot. Data collected included crop injury on a scale from 0% (no injury) to 100% (crop death) at 2, 4, and 6 wk after treatment (WAT), and plant stand. Two harvests were performed in which mature fruits were counted and weighed. Injury presented as interveinal bleaching only at PPAC 2 and 4 WAT. At this location 1,680 g ha–1 clomazone resulted in greater injury to ‘Sweet Sunset’ at 2 and 4 WAT (53% and 15%, respectively) than to ‘Pageant’ (19% and 3%, respectively); however, plant stand and yield were not affected by either clomazone rate. These results suggest that the clomazone rate range currently used for bell pepper (280 to 1,120 g ai ha–1) can be applied prior to transplanting plasticulture-grown banana pepper with minimal crop injury and without reducing yield

Percepción de los usuarios sobre los servicios brindados por la administración portuaria Bluff-Bluefields en la ruta Bluefields - Corn Island y viceversa en los meses de junio y julio 2022

El presente estudio se realizó en la ciudad de Bluefields, Región Autónoma de la Costa Caribe Sur (RACCS), en atención a la administración portuaria Bluff – Bluefields ubicada en el barrio Beholdeen frente donde fue la panadería Román, en dicha ciudad la empresa cuenta con un muelle ubicado en el barrio Pancasan. Los servicios que oferta la empresa han permitido potenciar la economía, así como el intercambio cultural entre ciudades de la región y nacionales, así expresa un funcionario entrevistado de la empresa, quien además menciona que estas ciudades costeñas son baluarte regional y cultural, de alta concurrencia de turistas (nacionales y extranjeros) y comerciantes. Desde que se iniciaron operaciones en 1980, la administración portuaria Bluff-Bluefields ha enmarcado estos servicios en la visión del gobierno, la cual consiste en brindar oportunidades y mejorar la vida de cada persona, de manera que exista una ruta que facilite conexiones que puedan subsanar las necesidades de transporte e intercambio, actividades que son importantes para la economía local. La presente investigación se realizó con una muestra correspondiente a 359 usuarios del servicio, quienes se encontraban en la embarcación abordando o desabordando. Los tipos de instrumentos aplicados fueron la encuesta a los usuarios y la entrevista a colaboradores administrativos y operativos de la institución, instrumentos que satisfactoriamente permitieron la obtención de información a mediad que se fueron aplicando. Es meritorio mencionar, que la investigación cumplió con los objetivos planteados, utilizando un diseño metodológico basado en el enfoque cualitativo y con una amplitud de corte transversal