The Use of Music Therapy in the Development of Socio-Emotional Skills in Children: A Literature Review

Socio-emotional development is an important domain of childhood development. Research indicates that the development of socio-emotional skills can have both short-term and long-term outcomes in other areas of a child’s life (Jones et al., 2015; Hammer at el., 2018). The most widely used approach in teaching social and emotional skills in children currently is through a social emotional learning (SEL) program. Music therapy is a commonly used modality with children to reach a variety of different goals. This paper explores current ways music is being implemented for improving socio-emotional skills, both within social emotional learning and in music therapy contexts. The implications of these findings support the inclusion of music therapy within SEL programs to increase engagement and effectiveness and the development of a music therapy-based SEL program

Sex differences matter in the gut: effect on mucosal immune activation and inflammation

Abstract Background Women and men have diverse responses to many infectious diseases. These differences are amplified following menopause. However, despite extensive information regarding the effects of sex hormones on immune cells, our knowledge is limited regarding the effects of sex and gender on the function of the mucosal immune system. Sex differences also manifest in the prevalence of gut associated inflammatory and autoimmune disorders, including Crohn’s disease, ulcerative colitis and Celiac disease. It is thus hypothesized that a baseline sex-associated difference in immune activation may predispose women to inflammation-associated disease. Methods Peripheral blood samples and small intestinal biopsies were obtained from 34 healthy men and women. Immunophenotypic analysis of isolated lymphocytes was performed by flow cytometry. Oligonucleotide analysis was used to study the transcriptional profile in the gut mucosal microenvironment while real-time PCR analysis was utilized to identify differential gene expression in isolated CD4+ T cells. Transcriptional analysis was confirmed by protein expression levels for genes of interest using fluorescent immunohistochemistry. Data was analyzed using the GraphPad software package. Results Women had higher levels of immune activation and inflammation-associated gene expression in gut mucosal samples. CD4+ and CD8+ T cells had a significantly higher level of immune activation-associated phenotype in peripheral blood as well as in gut associated lymphoid tissue along with higher levels of proliferating T cells. CD4+ T cells that showed upregulation of IL1β as well as the TH17 pathway-associated genes contributed a large part of the inflammatory profile. Conclusion In this study, we demonstrated an upregulation in gene expression related to immune function in the gut microenvironment of women compared to men, in the absence of disease or pathology. Upon closer investigation, CD4+ T cell activation levels were higher in the LPLs in women than in men. Sex differences in the mucosal immune system may predispose women to inflammation-associated diseases that are exacerbated following menopause. Our study highlights the need for more detailed analysis of the effects of sex differences in immune responses at mucosal effector sites